ME00987B - Novi postupak sinteze ivabradina i njegovih soli sa farmaceutski prihvatljivom kiselinom - Google Patents
Novi postupak sinteze ivabradina i njegovih soli sa farmaceutski prihvatljivom kiselinomInfo
- Publication number
- ME00987B ME00987B MEP-2010-55A MEP5510A ME00987B ME 00987 B ME00987 B ME 00987B ME P5510 A MEP5510 A ME P5510A ME 00987 B ME00987 B ME 00987B
- Authority
- ME
- Montenegro
- Prior art keywords
- ivabradine
- pharmaceutically acceptable
- addition salts
- acceptable acid
- synthesiis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Postupak sinteze ivabradina formule (I): i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0901555A FR2943667B1 (fr) | 2009-03-31 | 2009-03-31 | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
Publications (1)
Publication Number | Publication Date |
---|---|
ME00987B true ME00987B (me) | 2012-06-20 |
Family
ID=40984744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2010-55A ME00987B (me) | 2009-03-31 | 2009-03-31 | Novi postupak sinteze ivabradina i njegovih soli sa farmaceutski prihvatljivom kiselinom |
Country Status (37)
Country | Link |
---|---|
US (1) | US8101747B2 (me) |
EP (1) | EP2241554B1 (me) |
JP (1) | JP5107382B2 (me) |
KR (1) | KR101166630B1 (me) |
CN (2) | CN101851205B (me) |
AR (1) | AR075977A1 (me) |
AT (1) | ATE523494T1 (me) |
AU (1) | AU2010201058B2 (me) |
BR (1) | BRPI1000735A2 (me) |
CA (1) | CA2697562C (me) |
CL (1) | CL2010000254A1 (me) |
CY (1) | CY1112136T1 (me) |
DK (1) | DK2241554T3 (me) |
EA (1) | EA016335B1 (me) |
ES (1) | ES2373369T3 (me) |
FR (1) | FR2943667B1 (me) |
GE (1) | GEP20125460B (me) |
HK (2) | HK1148748A1 (me) |
HR (1) | HRP20110915T1 (me) |
JO (1) | JO2782B1 (me) |
MA (1) | MA31745B1 (me) |
ME (1) | ME00987B (me) |
MX (1) | MX2010003184A (me) |
MY (1) | MY145611A (me) |
NZ (1) | NZ584309A (me) |
PE (1) | PE20100714A1 (me) |
PL (1) | PL2241554T3 (me) |
PT (1) | PT2241554E (me) |
RS (1) | RS51962B (me) |
SA (1) | SA110310240B1 (me) |
SG (1) | SG165254A1 (me) |
SI (1) | SI2241554T1 (me) |
TW (1) | TWI419879B (me) |
UA (1) | UA102232C2 (me) |
UY (1) | UY32500A (me) |
WO (1) | WO2010112704A1 (me) |
ZA (1) | ZA201002121B (me) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2471780E (pt) * | 2007-05-30 | 2015-02-24 | Ind Swift Lab Ltd | Sais oxalato de ivabradina cristalinos e seus polimorfos |
CN103848789B (zh) * | 2012-11-29 | 2016-05-18 | 江苏恒瑞医药股份有限公司 | 一种伊伐布雷定的制备方法 |
CN103724266B (zh) * | 2014-01-20 | 2018-12-04 | 山东诚创医药技术开发有限公司 | 去甲伊伐布雷定盐及其制备方法和应用 |
EP3101010A1 (en) | 2015-06-03 | 2016-12-07 | Urquima S.A. | New method for the preparation of highly pure ivabradine base and salts thereof |
CN108530359A (zh) * | 2017-03-01 | 2018-09-14 | 浙江京新药业股份有限公司 | 一种伊伐布雷定杂质的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1140049A (en) * | 1965-04-02 | 1969-01-15 | Alphachimie S A | N-substituted tetrahydrobenzazepines |
US3743731A (en) * | 1971-03-16 | 1973-07-03 | Schering Corp | Substituted benzazepines for producing skeletal muscle relaxation |
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2870537A1 (fr) * | 2004-05-19 | 2005-11-25 | Servier Lab | Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
EP2097383B1 (en) * | 2006-11-30 | 2012-02-08 | Cadila Healthcare Limited | Process for preparation of ivabradine hydrochloride |
CN101284813B (zh) * | 2007-04-12 | 2012-08-15 | 上海优拓医药科技有限公司 | 伊伐布雷定的制备方法 |
PT2471780E (pt) | 2007-05-30 | 2015-02-24 | Ind Swift Lab Ltd | Sais oxalato de ivabradina cristalinos e seus polimorfos |
-
2009
- 2009-03-31 FR FR0901555A patent/FR2943667B1/fr not_active Expired - Fee Related
- 2009-03-31 ME MEP-2010-55A patent/ME00987B/me unknown
-
2010
- 2010-03-16 SG SG201001800-0A patent/SG165254A1/en unknown
- 2010-03-16 PE PE2010000154A patent/PE20100714A1/es not_active Application Discontinuation
- 2010-03-17 MY MYPI2010001176A patent/MY145611A/en unknown
- 2010-03-17 UY UY0001032500A patent/UY32500A/es not_active Application Discontinuation
- 2010-03-18 AU AU2010201058A patent/AU2010201058B2/en not_active Ceased
- 2010-03-18 MA MA32704A patent/MA31745B1/fr unknown
- 2010-03-22 CL CL2010000254A patent/CL2010000254A1/es unknown
- 2010-03-23 MX MX2010003184A patent/MX2010003184A/es active IP Right Grant
- 2010-03-24 CA CA2697562A patent/CA2697562C/fr not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02121A patent/ZA201002121B/en unknown
- 2010-03-29 TW TW099109451A patent/TWI419879B/zh not_active IP Right Cessation
- 2010-03-29 SA SA110310240A patent/SA110310240B1/ar unknown
- 2010-03-29 UA UAA201003588A patent/UA102232C2/uk unknown
- 2010-03-29 US US12/798,042 patent/US8101747B2/en not_active Expired - Fee Related
- 2010-03-29 AR ARP100101002A patent/AR075977A1/es not_active Application Discontinuation
- 2010-03-29 NZ NZ584309A patent/NZ584309A/en not_active IP Right Cessation
- 2010-03-29 GE GEAP201011741A patent/GEP20125460B/en unknown
- 2010-03-30 ES ES10290166T patent/ES2373369T3/es active Active
- 2010-03-30 EA EA201000397A patent/EA016335B1/ru not_active IP Right Cessation
- 2010-03-30 PT PT10290166T patent/PT2241554E/pt unknown
- 2010-03-30 SI SI201030013T patent/SI2241554T1/sl unknown
- 2010-03-30 EP EP10290166A patent/EP2241554B1/fr active Active
- 2010-03-30 PL PL10290166T patent/PL2241554T3/pl unknown
- 2010-03-30 DK DK10290166.7T patent/DK2241554T3/da active
- 2010-03-30 RS RS20110479A patent/RS51962B/en unknown
- 2010-03-30 JP JP2010076768A patent/JP5107382B2/ja active Active
- 2010-03-30 AT AT10290166T patent/ATE523494T1/de active
- 2010-03-30 WO PCT/FR2010/000268 patent/WO2010112704A1/fr active Application Filing
- 2010-03-30 BR BRPI1000735-0A patent/BRPI1000735A2/pt not_active Application Discontinuation
- 2010-03-31 KR KR1020100029258A patent/KR101166630B1/ko active IP Right Grant
- 2010-03-31 CN CN2010101547205A patent/CN101851205B/zh not_active Expired - Fee Related
- 2010-03-31 CN CN201210034916.XA patent/CN102603634B/zh not_active Expired - Fee Related
- 2010-03-31 JO JO2010104A patent/JO2782B1/en active
-
2011
- 2011-03-28 HK HK11103103.5A patent/HK1148748A1/xx not_active IP Right Cessation
- 2011-12-05 CY CY20111101203T patent/CY1112136T1/el unknown
- 2011-12-06 HR HR20110915T patent/HRP20110915T1/hr unknown
-
2012
- 2012-10-24 HK HK12110572.1A patent/HK1169827A1/xx not_active IP Right Cessation
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