EA201000397A1 - Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой - Google Patents

Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой

Info

Publication number
EA201000397A1
EA201000397A1 EA201000397A EA201000397A EA201000397A1 EA 201000397 A1 EA201000397 A1 EA 201000397A1 EA 201000397 A EA201000397 A EA 201000397A EA 201000397 A EA201000397 A EA 201000397A EA 201000397 A1 EA201000397 A1 EA 201000397A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
salts
ivabradin
connection
new method
Prior art date
Application number
EA201000397A
Other languages
English (en)
Other versions
EA016335B1 (ru
Inventor
Жан-Луи Пеглион
Эмея Дессинье
Бернар Серки
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40984744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201000397(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA201000397A1 publication Critical patent/EA201000397A1/ru
Publication of EA016335B1 publication Critical patent/EA016335B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Способ синтеза ивабрадина формулы (I)и его солей присоединения с фармацевтически приемлемой кислотой.
EA201000397A 2009-03-31 2010-03-30 Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой EA016335B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901555A FR2943667B1 (fr) 2009-03-31 2009-03-31 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.

Publications (2)

Publication Number Publication Date
EA201000397A1 true EA201000397A1 (ru) 2010-12-30
EA016335B1 EA016335B1 (ru) 2012-04-30

Family

ID=40984744

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000397A EA016335B1 (ru) 2009-03-31 2010-03-30 Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой

Country Status (37)

Country Link
US (1) US8101747B2 (ru)
EP (1) EP2241554B1 (ru)
JP (1) JP5107382B2 (ru)
KR (1) KR101166630B1 (ru)
CN (2) CN102603634B (ru)
AR (1) AR075977A1 (ru)
AT (1) ATE523494T1 (ru)
AU (1) AU2010201058B2 (ru)
BR (1) BRPI1000735A2 (ru)
CA (1) CA2697562C (ru)
CL (1) CL2010000254A1 (ru)
CY (1) CY1112136T1 (ru)
DK (1) DK2241554T3 (ru)
EA (1) EA016335B1 (ru)
ES (1) ES2373369T3 (ru)
FR (1) FR2943667B1 (ru)
GE (1) GEP20125460B (ru)
HK (2) HK1148748A1 (ru)
HR (1) HRP20110915T1 (ru)
JO (1) JO2782B1 (ru)
MA (1) MA31745B1 (ru)
ME (1) ME00987B (ru)
MX (1) MX2010003184A (ru)
MY (1) MY145611A (ru)
NZ (1) NZ584309A (ru)
PE (1) PE20100714A1 (ru)
PL (1) PL2241554T3 (ru)
PT (1) PT2241554E (ru)
RS (1) RS51962B (ru)
SA (1) SA110310240B1 (ru)
SG (1) SG165254A1 (ru)
SI (1) SI2241554T1 (ru)
TW (1) TWI419879B (ru)
UA (1) UA102232C2 (ru)
UY (1) UY32500A (ru)
WO (1) WO2010112704A1 (ru)
ZA (1) ZA201002121B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2471780E (pt) * 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
CN103724266B (zh) * 2014-01-20 2018-12-04 山东诚创医药技术开发有限公司 去甲伊伐布雷定盐及其制备方法和应用
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN108530359A (zh) * 2017-03-01 2018-09-14 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140049A (en) * 1965-04-02 1969-01-15 Alphachimie S A N-substituted tetrahydrobenzazepines
US3743731A (en) * 1971-03-16 1973-07-03 Schering Corp Substituted benzazepines for producing skeletal muscle relaxation
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2870537A1 (fr) * 2004-05-19 2005-11-25 Servier Lab Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP2097383B1 (en) * 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
PT2471780E (pt) 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos

Also Published As

Publication number Publication date
KR20100109526A (ko) 2010-10-08
CN101851205B (zh) 2013-02-13
AU2010201058A1 (en) 2010-10-14
GEP20125460B (en) 2012-03-26
US20100249397A1 (en) 2010-09-30
ATE523494T1 (de) 2011-09-15
BRPI1000735A2 (pt) 2011-04-19
JP5107382B2 (ja) 2012-12-26
DK2241554T3 (da) 2011-12-12
EA016335B1 (ru) 2012-04-30
ZA201002121B (en) 2010-11-24
HK1169827A1 (en) 2013-02-08
CY1112136T1 (el) 2015-11-04
JP2010241809A (ja) 2010-10-28
HK1148748A1 (en) 2011-09-16
NZ584309A (en) 2010-11-26
CL2010000254A1 (es) 2011-04-25
MA31745B1 (fr) 2010-10-01
US8101747B2 (en) 2012-01-24
CA2697562A1 (fr) 2010-09-30
EP2241554B1 (fr) 2011-09-07
FR2943667B1 (fr) 2011-05-06
FR2943667A1 (fr) 2010-10-01
CN101851205A (zh) 2010-10-06
PL2241554T3 (pl) 2012-01-31
AU2010201058B2 (en) 2015-02-05
ES2373369T3 (es) 2012-02-02
PT2241554E (pt) 2011-10-17
MX2010003184A (es) 2010-10-05
SI2241554T1 (sl) 2012-01-31
PE20100714A1 (es) 2010-10-30
KR101166630B1 (ko) 2012-07-19
EP2241554A1 (fr) 2010-10-20
CN102603634A (zh) 2012-07-25
CN102603634B (zh) 2014-04-16
TW201040144A (en) 2010-11-16
TWI419879B (zh) 2013-12-21
UY32500A (es) 2010-09-30
UA102232C2 (ru) 2013-06-25
MY145611A (en) 2012-03-05
AR075977A1 (es) 2011-05-11
JO2782B1 (en) 2014-03-15
HRP20110915T1 (hr) 2011-12-31
SG165254A1 (en) 2010-10-28
WO2010112704A1 (fr) 2010-10-07
SA110310240B1 (ar) 2013-07-28
ME00987B (me) 2012-06-20
CA2697562C (fr) 2012-05-15
RS51962B (en) 2012-02-29

Similar Documents

Publication Publication Date Title
EA200901563A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
EA201101147A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
EA201000398A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
EA201200498A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201000397A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
EA201200123A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201100230A1 (ru) Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
EA201201385A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201301136A2 (ru) Новый способ синтеза (2e)-3-(3,4-диметоксифенил)проп-2-еннитрила, применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201301235A1 (ru) Новый способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201400473A1 (ru) Способ синтеза 3,4-диметоксибицикло[4.2.0]окта-1,3,5-триен-7-карбонитрила и применение для синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
EA201300281A2 (ru) Новый способ синтеза ивабрадина и его аддитивных солей с фармацевтически приемлемой кислотой
EA201201571A1 (ru) Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201301020A1 (ru) Новый способ синтеза 3-(2-бром-4,5-диметоксифенил)пропаннитрила и применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
SG165255A1 (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU