BR0316645A - Derivados de isoindol - Google Patents

Derivados de isoindol

Info

Publication number
BR0316645A
BR0316645A BR0316645-7A BR0316645A BR0316645A BR 0316645 A BR0316645 A BR 0316645A BR 0316645 A BR0316645 A BR 0316645A BR 0316645 A BR0316645 A BR 0316645A
Authority
BR
Brazil
Prior art keywords
isoindole derivatives
compound
derivatives
isoindole
anesthesia
Prior art date
Application number
BR0316645-7A
Other languages
English (en)
Inventor
Kouhei Toyooka
Norimasa Kanamitsu
Masakazu Yoshimura
Haruo Kuriyama
Takashi Tamura
Original Assignee
Maruishi Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32375878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0316645(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Maruishi Pharma filed Critical Maruishi Pharma
Publication of BR0316645A publication Critical patent/BR0316645A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

"DERIVADOS DE ISOINDOL". é provido um composto isoindolina da Fórmula (I): O composto é útil para anestesia através de indução de sedação em um mamífero.
BR0316645-7A 2002-11-26 2003-11-25 Derivados de isoindol BR0316645A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002342399 2002-11-26
PCT/JP2003/014986 WO2004048332A1 (ja) 2002-11-26 2003-11-25 イソインドリン誘導体

Publications (1)

Publication Number Publication Date
BR0316645A true BR0316645A (pt) 2005-10-11

Family

ID=32375878

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316645-7A BR0316645A (pt) 2002-11-26 2003-11-25 Derivados de isoindol

Country Status (24)

Country Link
US (2) US7521451B2 (pt)
EP (1) EP1566378B1 (pt)
KR (1) KR101149978B1 (pt)
CN (1) CN100548980C (pt)
AR (1) AR042139A1 (pt)
AU (1) AU2003284669B2 (pt)
BR (1) BR0316645A (pt)
CA (1) CA2505029C (pt)
DK (1) DK1566378T3 (pt)
EC (1) ECSP055886A (pt)
ES (1) ES2393645T3 (pt)
HK (1) HK1079201A1 (pt)
IL (1) IL168477A (pt)
MX (1) MXPA05005580A (pt)
NO (1) NO333165B1 (pt)
NZ (1) NZ539834A (pt)
PE (1) PE20040698A1 (pt)
PL (1) PL376890A1 (pt)
PT (1) PT1566378E (pt)
RU (1) RU2343145C2 (pt)
TW (1) TWI320408B (pt)
UY (1) UY28094A1 (pt)
WO (1) WO2004048332A1 (pt)
ZA (1) ZA200503697B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06013766A (es) * 2004-05-24 2007-02-08 Maruishi Pharma Composicion para el control del dolor neuropatico.
CN101316836A (zh) 2005-11-01 2008-12-03 詹森药业有限公司 作为葡萄糖激酶变构调节剂的取代的二氢异吲哚酮类
US8110681B2 (en) 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
JP2009542803A (ja) * 2006-07-12 2009-12-03 アストラゼネカ・アクチエボラーグ 鎮痛剤としての３−オキソイソインドリン−１−カルボキサミド誘導体
TWI417100B (zh) * 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
CA2700841A1 (en) * 2007-09-27 2009-04-02 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Isoindoline compounds for the treatment of spinal muscular atrophy and other uses
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
JP6409004B2 (ja) 2013-01-28 2018-10-17 ハー・ルンドベック・アクチエゼルスカベット ソルチリン阻害剤としてのｎ置換された５置換フタルアミド酸
CN105254554B (zh) * 2014-07-14 2018-01-30 南开大学 一种制备异吲哚啉酮类化合物的方法
CN104803905B (zh) * 2015-04-17 2017-10-10 复旦大学 一种合成异吲哚啉‑1‑酮衍生物的方法
ITRM20150196A1 (it) * 2015-05-05 2016-11-05 Univ Degli Studi Di Salerno Isoindolinoni, procedimenti per la produzione di loro derivati chirali e impiego di questi ultimi
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
CN110698445B (zh) * 2018-07-09 2023-05-12 四川大学 一类3-胺烷基苯酞类化合物、其制备方法和用途
US20220388978A1 (en) * 2019-08-27 2022-12-08 Regents Of The University Of Michigan Cereblon e3 ligase inhibitors
CN110498759A (zh) * 2019-09-12 2019-11-26 天津瑞岭化工有限公司 异吲哚啉酮类化合物的合成方法
WO2021143816A1 (zh) * 2020-01-16 2021-07-22 江苏恒瑞医药股份有限公司 稠合酰亚胺类衍生物、其制备方法及其在医药上的应用
TW202140448A (zh) * 2020-01-16 2021-11-01 大陸商江蘇恆瑞醫藥股份有限公司 並環醯亞胺類衍生物、其製備方法及其在醫藥上的應用
CN114394926B (zh) * 2022-02-28 2023-06-27 大连大学 N,3-二取代-1-异吲哚啉酮类化合物的高产率合成方法
CN114539124B (zh) * 2022-02-28 2023-07-21 大连大学 一种对映选择性合成n,3-二取代-1-异吲哚啉酮化合物的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2101081B1 (pt) * 1970-08-19 1974-01-11 Rhone Poulenc Sa
US3679686A (en) 1970-09-09 1972-07-25 Janssen Pharmaceutica Nv N-(bicycloamino-alkanoyl)-anilines
FR2117740B1 (pt) 1970-12-14 1974-04-12 Rhone Poulenc Sa
JPS4712322U (pt) 1971-03-09 1972-10-13
GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
OA05287A (fr) 1975-04-07 1981-02-28 Rhone Poulenc Ind Nouveaux composés hétérocycliques et leur préparation.
DE3378763D1 (en) 1982-04-02 1989-02-02 Takeda Chemical Industries Ltd Condensed pyrrolinone derivatives, and their production
JPS58189163A (ja) 1982-04-02 1983-11-04 Takeda Chem Ind Ltd 縮合ピロリノン誘導体
US5932613A (en) 1996-07-03 1999-08-03 Millennium Pharmaceuticals, Inc. Anticancer agents
KR19980074060A (ko) 1997-03-21 1998-11-05 김윤배 신규한 치환된 3,4-디알콕시페닐 유도체
IL133621A0 (en) * 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
BR0011028A (pt) * 1999-06-10 2002-02-19 Bridge Pharma Inc Agentes anestésicos dérmicos
MXPA06013766A (es) * 2004-05-24 2007-02-08 Maruishi Pharma Composicion para el control del dolor neuropatico.

Also Published As

Publication number Publication date
MXPA05005580A (es) 2005-11-23
AU2003284669A1 (en) 2004-06-18
IL168477A (en) 2010-11-30
ZA200503697B (en) 2006-10-25
PE20040698A1 (es) 2004-10-30
CA2505029C (en) 2012-03-20
ECSP055886A (es) 2005-09-20
NO333165B1 (no) 2013-03-25
CA2505029A1 (en) 2004-06-10
UY28094A1 (es) 2004-06-30
KR101149978B1 (ko) 2012-06-01
KR20050070140A (ko) 2005-07-05
CN100548980C (zh) 2009-10-14
ES2393645T3 (es) 2012-12-26
WO2004048332A1 (ja) 2004-06-10
PL376890A1 (pl) 2006-01-09
EP1566378B1 (en) 2012-08-15
EP1566378A4 (en) 2011-03-23
US20060052392A1 (en) 2006-03-09
EP1566378A1 (en) 2005-08-24
RU2343145C2 (ru) 2009-01-10
AU2003284669B2 (en) 2009-11-12
HK1079201A1 (en) 2006-03-31
US20090170835A1 (en) 2009-07-02
DK1566378T3 (da) 2012-11-12
NZ539834A (en) 2007-08-31
CN1741995A (zh) 2006-03-01
US7521451B2 (en) 2009-04-21
TWI320408B (en) 2010-02-11
NO20052529L (no) 2005-06-23
AR042139A1 (es) 2005-06-08
TW200416218A (en) 2004-09-01
RU2005120003A (ru) 2006-01-20
PT1566378E (pt) 2012-11-29

Similar Documents

Publication Publication Date Title
BR0316645A (pt) Derivados de isoindol
ATE506354T1 (de) Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
ATE491703T1 (de) Phthalazinonderivate
ATE297910T1 (de) Retinoid x rezeptormodulatoren
CY1113657T1 (el) Νεα παραγωγα βενζοφαινονης ή αλατα αυτων
CY1109989T1 (el) 3,4-di-υποκαθισταμενες cyclobutene-1,2-diones ως συνδετες του υποδοχεα των cxc-χημειοκινων
CY1111867T1 (el) Ενωση ενεργοποιησης ppar και φαρμακευτικη συνθεση που περιεχει αυτη
SE0000540D0 (sv) New compounds
ITRM20010464A1 (it) Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.
NO20052989L (no) Terapeutiske forbindelser.
CY1105721T1 (el) Δερματικοι αναισθητικοι παραγοντες
BR0214268A (pt) Aperfeiçoamentos em relação a abrilhantadores ópticos
ATE477256T1 (de) Thienylverbindungen
CY1106471T1 (el) Νεα μεθοδος συνθεσης της περινδροπριλης και των φαρμακευτικως αποδεκτων αλατων αυτης
CY1106544T1 (el) Μεθοδος συνθεσεως υπερινδοπριλης και τα φαρμακευτικως αποδεκτα αλατα αυτης
EA200501925A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
NO20022977D0 (no) Substituerte homopiperidinylbenzimidazolanaloger som fundiske relaksanter
EA200501557A1 (ru) Новый способ синтеза (2s)-индолин-2-карбоновой кислоты и использование в синтезе периндоприла
EA200600455A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EA200600456A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
MXPA05006957A (es) Nuevos derivados de fosforamida.
EA200600454A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EA200601086A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25G Requested change of headquarter approved

Owner name: MARUISHI PHARMACEUTICAL CO., LTD. (JP)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2281 DE 23/09/2014