EA200600455A1 - Новый способ синтеза периндоприла и его фармацевтически приемлемых солей - Google Patents

Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Info

Publication number
EA200600455A1
EA200600455A1 EA200600455A EA200600455A EA200600455A1 EA 200600455 A1 EA200600455 A1 EA 200600455A1 EA 200600455 A EA200600455 A EA 200600455A EA 200600455 A EA200600455 A EA 200600455A EA 200600455 A1 EA200600455 A1 EA 200600455A1
Authority
EA
Eurasian Patent Office
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
new method
Prior art date
Application number
EA200600455A
Other languages
English (en)
Other versions
EA008626B1 (ru
Inventor
Тьерри Дюбюффе
Жан-Пьер Лекув
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200600455A1 publication Critical patent/EA200600455A1/ru
Publication of EA008626B1 publication Critical patent/EA008626B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Способ синтеза периндоприла формулы (I)и его фармацевтически приемлемых солей.
EA200600455A 2003-08-29 2004-08-27 Новый способ синтеза периндоприла и его фармацевтически приемлемых солей EA008626B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03292133A EP1371659B1 (fr) 2003-08-29 2003-08-29 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/002198 WO2005023843A1 (fr) 2003-08-29 2004-08-27 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
EA200600455A1 true EA200600455A1 (ru) 2006-08-25
EA008626B1 EA008626B1 (ru) 2007-06-29

Family

ID=29558494

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600455A EA008626B1 (ru) 2003-08-29 2004-08-27 Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Country Status (18)

Country Link
US (1) US7223872B2 (ru)
EP (1) EP1371659B1 (ru)
JP (1) JP4331207B2 (ru)
CN (1) CN100374459C (ru)
AR (1) AR045517A1 (ru)
AT (1) ATE306496T1 (ru)
AU (1) AU2004270429B2 (ru)
DE (1) DE60301820T2 (ru)
DK (1) DK1371659T3 (ru)
EA (1) EA008626B1 (ru)
ES (1) ES2250853T3 (ru)
HK (1) HK1097852A1 (ru)
MY (1) MY136288A (ru)
NZ (1) NZ545338A (ru)
PL (1) PL211507B1 (ru)
SI (1) SI1371659T1 (ru)
WO (1) WO2005023843A1 (ru)
ZA (1) ZA200601426B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1380591T3 (da) * 2003-08-29 2006-01-23 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
DE60308102T2 (de) * 2003-08-29 2007-06-21 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
US7456296B2 (en) * 2003-10-21 2008-11-25 Lupin Ltd Method for preparation of crystalline perindopril erbumine
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
PT1679072E (pt) 2005-01-06 2008-12-22 Ipca Lab Ltd Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN113980096A (zh) * 2021-11-29 2022-01-28 绍兴市上虞区武汉理工大学高等研究院 一种吨级培哚普利叔丁胺的合成工艺方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1319668T3 (da) * 2003-03-12 2005-02-14 Servier Lab Fremgangsmåde til syntese af (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese af perindopril
DK1380591T3 (da) * 2003-08-29 2006-01-23 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf

Also Published As

Publication number Publication date
WO2005023843A1 (fr) 2005-03-17
ZA200601426B (en) 2007-05-30
ES2250853T3 (es) 2006-04-16
ATE306496T1 (de) 2005-10-15
AU2004270429A1 (en) 2005-03-17
AR045517A1 (es) 2005-11-02
EP1371659B1 (fr) 2005-10-12
US7223872B2 (en) 2007-05-29
AU2004270429B2 (en) 2007-05-24
SI1371659T1 (sl) 2006-02-28
US20070088168A1 (en) 2007-04-19
PL211507B1 (pl) 2012-05-31
EA008626B1 (ru) 2007-06-29
DE60301820T2 (de) 2006-07-13
JP2007536202A (ja) 2007-12-13
PL379627A1 (pl) 2006-10-30
JP4331207B2 (ja) 2009-09-16
DK1371659T3 (da) 2005-11-21
CN100374459C (zh) 2008-03-12
CN1835965A (zh) 2006-09-20
MY136288A (en) 2008-09-30
DE60301820D1 (de) 2006-02-23
HK1097852A1 (en) 2007-07-06
NZ545338A (en) 2009-03-31
EP1371659A1 (fr) 2003-12-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU