PT1679072E - Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril - Google Patents

Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril Download PDF

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Publication number
PT1679072E
PT1679072E PT05113099T PT05113099T PT1679072E PT 1679072 E PT1679072 E PT 1679072E PT 05113099 T PT05113099 T PT 05113099T PT 05113099 T PT05113099 T PT 05113099T PT 1679072 E PT1679072 E PT 1679072E
Authority
PT
Portugal
Prior art keywords
perindopril
synthesis
alanyl
octahydro
indole
Prior art date
Application number
PT05113099T
Other languages
English (en)
Inventor
Ashok Kumar
Satish Rajanikant Soudagar
Arpana Mathur
Sanjay Tukaram Gunjal
Nalinakshya Balaram Panda
Dilip Uttam Jadhav
Original Assignee
Ipca Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Lab Ltd filed Critical Ipca Lab Ltd
Publication of PT1679072E publication Critical patent/PT1679072E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT05113099T 2005-01-06 2005-12-30 Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril PT1679072E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN17MU2005 2005-01-06

Publications (1)

Publication Number Publication Date
PT1679072E true PT1679072E (pt) 2008-12-22

Family

ID=36269938

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05113099T PT1679072E (pt) 2005-01-06 2005-12-30 Processo para a síntese de derivados de ácido (2s,3as,7as)-1-(s)-alanil-octa-hidro-1h-indole-2-carboxílico e utilização na síntese de perindopril

Country Status (8)

Country Link
EP (2) EP1679072B9 (pt)
AT (1) ATE409036T1 (pt)
DE (1) DE602005009918D1 (pt)
DK (1) DK1679072T5 (pt)
ES (1) ES2314583T4 (pt)
PL (1) PL1679072T3 (pt)
PT (1) PT1679072E (pt)
SI (1) SI1679072T1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1679072B9 (en) 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
WO2014057404A1 (en) * 2012-10-10 2014-04-17 Piramal Enterprises Limited An improved process for preparation of perindopril intermediate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
IT1292426B1 (it) * 1997-06-27 1999-02-08 Nicox Sa Sali nitrati di ace-inibitori
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
DE60220877T2 (de) 2002-01-30 2008-04-10 Les Laboratoires Servier Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
PT1362864E (pt) 2003-06-30 2007-07-23 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico
ATE315043T1 (de) 2003-06-30 2006-02-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
ES2272922T3 (es) 2003-08-29 2007-05-01 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
SI1380591T1 (sl) 2003-08-29 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
DK1371659T3 (da) 2003-08-29 2005-11-21 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
EP1420029B9 (fr) * 2003-12-10 2008-11-12 Les Laboratoires Servier Procédé de synthèse du perindopril et ses sels pharmaceutiquement acceptables
EP1679072B9 (en) 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril

Also Published As

Publication number Publication date
PL1679072T3 (pl) 2009-03-31
ES2314583T4 (es) 2009-05-18
ES2314583T3 (es) 2009-03-16
EP1987828A1 (en) 2008-11-05
DK1679072T3 (da) 2009-02-09
DE602005009918D1 (de) 2008-11-06
ATE409036T1 (de) 2008-10-15
DK1679072T5 (da) 2009-04-20
EP1679072B1 (en) 2008-09-24
SI1679072T1 (sl) 2009-02-28
EP1679072B9 (en) 2009-09-02
EP1679072A1 (en) 2006-07-12

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