SI1338591T1 - NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA - Google Patents
NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILAInfo
- Publication number
- SI1338591T1 SI1338591T1 SI200330107T SI200330107T SI1338591T1 SI 1338591 T1 SI1338591 T1 SI 1338591T1 SI 200330107 T SI200330107 T SI 200330107T SI 200330107 T SI200330107 T SI 200330107T SI 1338591 T1 SI1338591 T1 SI 1338591T1
- Authority
- SI
- Slovenia
- Prior art keywords
- synthesis
- perhydroindole
- perindopril
- esters
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290487A EP1338591B1 (fr) | 2003-02-28 | 2003-02-28 | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1338591T1 true SI1338591T1 (sl) | 2006-02-28 |
Family
ID=27635945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200330107T SI1338591T1 (sl) | 2003-02-28 | 2003-02-28 | NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7157484B2 (sl) |
| EP (1) | EP1338591B1 (sl) |
| JP (1) | JP4563371B2 (sl) |
| CN (1) | CN100364974C (sl) |
| AR (1) | AR043411A1 (sl) |
| AT (1) | ATE307801T1 (sl) |
| AU (1) | AU2004218200B2 (sl) |
| DE (1) | DE60301980T2 (sl) |
| DK (1) | DK1338591T3 (sl) |
| EA (1) | EA007948B1 (sl) |
| ES (1) | ES2250847T3 (sl) |
| HK (1) | HK1086262A1 (sl) |
| MY (1) | MY135169A (sl) |
| NZ (1) | NZ541422A (sl) |
| PL (1) | PL219733B1 (sl) |
| SI (1) | SI1338591T1 (sl) |
| WO (1) | WO2004078707A2 (sl) |
| ZA (1) | ZA200505779B (sl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
| EA011712B1 (ru) * | 2004-03-29 | 2009-04-28 | Ле Лаборатуар Сервье | Способ производства твёрдой фармацевтической композиции |
| SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| CN101090886B (zh) * | 2004-12-28 | 2011-05-18 | 帝斯曼知识产权资产管理有限公司 | 对映体富集的吲哚啉-2-羧酸的制备方法 |
| CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ202903A (en) * | 1981-12-29 | 1988-01-08 | Hoechst Ag | 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| NL1008302C2 (nl) * | 1998-02-13 | 1999-08-16 | Dsm Nv | Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| PT1403277E (pt) * | 2003-02-28 | 2005-11-30 | Servier Lab | Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril |
-
2003
- 2003-02-28 SI SI200330107T patent/SI1338591T1/sl unknown
- 2003-02-28 AT AT03290487T patent/ATE307801T1/de active
- 2003-02-28 ES ES03290487T patent/ES2250847T3/es not_active Expired - Lifetime
- 2003-02-28 EP EP03290487A patent/EP1338591B1/fr not_active Expired - Lifetime
- 2003-02-28 DK DK03290487T patent/DK1338591T3/da active
- 2003-02-28 DE DE60301980T patent/DE60301980T2/de not_active Expired - Lifetime
-
2004
- 2004-02-27 AU AU2004218200A patent/AU2004218200B2/en not_active Ceased
- 2004-02-27 AR ARP040100611A patent/AR043411A1/es not_active Application Discontinuation
- 2004-02-27 CN CNB2004800054078A patent/CN100364974C/zh not_active Expired - Fee Related
- 2004-02-27 JP JP2006500161A patent/JP4563371B2/ja not_active Expired - Fee Related
- 2004-02-27 EA EA200501256A patent/EA007948B1/ru not_active IP Right Cessation
- 2004-02-27 ZA ZA200505779A patent/ZA200505779B/xx unknown
- 2004-02-27 PL PL377232A patent/PL219733B1/pl unknown
- 2004-02-27 WO PCT/FR2004/000444 patent/WO2004078707A2/fr active Application Filing
- 2004-02-27 US US10/546,967 patent/US7157484B2/en not_active Expired - Fee Related
- 2004-02-27 MY MYPI20040683A patent/MY135169A/en unknown
- 2004-02-27 NZ NZ541422A patent/NZ541422A/en not_active IP Right Cessation
-
2006
- 2006-05-29 HK HK06106191A patent/HK1086262A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE307801T1 (de) | 2005-11-15 |
| DE60301980D1 (de) | 2005-12-01 |
| MY135169A (en) | 2008-02-29 |
| US20060167273A1 (en) | 2006-07-27 |
| CN100364974C (zh) | 2008-01-30 |
| EA007948B1 (ru) | 2007-02-27 |
| AU2004218200A1 (en) | 2004-09-16 |
| DK1338591T3 (da) | 2006-01-23 |
| AR043411A1 (es) | 2005-07-27 |
| EA200501256A1 (ru) | 2006-04-28 |
| JP4563371B2 (ja) | 2010-10-13 |
| AU2004218200B2 (en) | 2009-07-30 |
| PL377232A1 (pl) | 2006-01-23 |
| CN1753869A (zh) | 2006-03-29 |
| PL219733B1 (pl) | 2015-07-31 |
| DE60301980T2 (de) | 2006-07-27 |
| NZ541422A (en) | 2008-03-28 |
| JP2006519175A (ja) | 2006-08-24 |
| EP1338591A1 (fr) | 2003-08-27 |
| US7157484B2 (en) | 2007-01-02 |
| WO2004078707A2 (fr) | 2004-09-16 |
| WO2004078707A3 (fr) | 2004-10-14 |
| ES2250847T3 (es) | 2006-04-16 |
| EP1338591B1 (fr) | 2005-10-26 |
| HK1086262A1 (en) | 2006-09-15 |
| ZA200505779B (en) | 2006-09-27 |
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