HK1086262A1 - Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis - Google Patents

Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis

Info

Publication number
HK1086262A1
HK1086262A1 HK06106191A HK06106191A HK1086262A1 HK 1086262 A1 HK1086262 A1 HK 1086262A1 HK 06106191 A HK06106191 A HK 06106191A HK 06106191 A HK06106191 A HK 06106191A HK 1086262 A1 HK1086262 A1 HK 1086262A1
Authority
HK
Hong Kong
Prior art keywords
perhydroindole
synthesising
esters
carboxylic acid
novel method
Prior art date
Application number
HK06106191A
Other languages
English (en)
Inventor
Dubuffet Thierry
Langolis Pascal
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1086262A1 publication Critical patent/HK1086262A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06106191A 2003-02-28 2006-05-29 Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis HK1086262A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03290487A EP1338591B1 (fr) 2003-02-28 2003-02-28 Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
PCT/FR2004/000444 WO2004078707A2 (fr) 2003-02-28 2004-02-27 Nouveau procede de synthese de lacide (2s, 3as, 7as)-perhydroindole-2-carboxylique et de ses esters et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
HK1086262A1 true HK1086262A1 (en) 2006-09-15

Family

ID=27635945

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06106191A HK1086262A1 (en) 2003-02-28 2006-05-29 Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis

Country Status (18)

Country Link
US (1) US7157484B2 (xx)
EP (1) EP1338591B1 (xx)
JP (1) JP4563371B2 (xx)
CN (1) CN100364974C (xx)
AR (1) AR043411A1 (xx)
AT (1) ATE307801T1 (xx)
AU (1) AU2004218200B2 (xx)
DE (1) DE60301980T2 (xx)
DK (1) DK1338591T3 (xx)
EA (1) EA007948B1 (xx)
ES (1) ES2250847T3 (xx)
HK (1) HK1086262A1 (xx)
MY (1) MY135169A (xx)
NZ (1) NZ541422A (xx)
PL (1) PL219733B1 (xx)
SI (1) SI1338591T1 (xx)
WO (1) WO2004078707A2 (xx)
ZA (1) ZA200505779B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
HUE031058T2 (en) * 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
ATE515496T1 (de) * 2004-12-28 2011-07-15 Dsm Ip Assets Bv Verfahren zur herstellung von enantiomerenangereicherter indolin-2-carbonsäure
CN100391945C (zh) * 2005-05-31 2008-06-04 浙江大学 一种s-(-)-吲哚啉-2-羧酸的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
NL1008302C2 (nl) * 1998-02-13 1999-08-16 Dsm Nv Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
SI1403277T1 (sl) * 2003-02-28 2005-12-31 Servier Lab NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-((S)-ALANIL)-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA PRI SINTEZI PERINDOPRILA

Also Published As

Publication number Publication date
WO2004078707A3 (fr) 2004-10-14
MY135169A (en) 2008-02-29
DE60301980D1 (de) 2005-12-01
CN100364974C (zh) 2008-01-30
DE60301980T2 (de) 2006-07-27
PL377232A1 (pl) 2006-01-23
SI1338591T1 (sl) 2006-02-28
WO2004078707A2 (fr) 2004-09-16
AR043411A1 (es) 2005-07-27
EA007948B1 (ru) 2007-02-27
ZA200505779B (en) 2006-09-27
CN1753869A (zh) 2006-03-29
AU2004218200B2 (en) 2009-07-30
EA200501256A1 (ru) 2006-04-28
EP1338591B1 (fr) 2005-10-26
JP4563371B2 (ja) 2010-10-13
US7157484B2 (en) 2007-01-02
JP2006519175A (ja) 2006-08-24
ES2250847T3 (es) 2006-04-16
ATE307801T1 (de) 2005-11-15
DK1338591T3 (da) 2006-01-23
AU2004218200A1 (en) 2004-09-16
EP1338591A1 (fr) 2003-08-27
US20060167273A1 (en) 2006-07-27
NZ541422A (en) 2008-03-28
PL219733B1 (pl) 2015-07-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190225