DK1338591T3 - Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril - Google Patents
Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindoprilInfo
- Publication number
- DK1338591T3 DK1338591T3 DK03290487T DK03290487T DK1338591T3 DK 1338591 T3 DK1338591 T3 DK 1338591T3 DK 03290487 T DK03290487 T DK 03290487T DK 03290487 T DK03290487 T DK 03290487T DK 1338591 T3 DK1338591 T3 DK 1338591T3
- Authority
- DK
- Denmark
- Prior art keywords
- synthesis
- perhydroindole
- perindopril
- esters
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290487A EP1338591B1 (fr) | 2003-02-28 | 2003-02-28 | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1338591T3 true DK1338591T3 (da) | 2006-01-23 |
Family
ID=27635945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03290487T DK1338591T3 (da) | 2003-02-28 | 2003-02-28 | Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7157484B2 (da) |
| EP (1) | EP1338591B1 (da) |
| JP (1) | JP4563371B2 (da) |
| CN (1) | CN100364974C (da) |
| AR (1) | AR043411A1 (da) |
| AT (1) | ATE307801T1 (da) |
| AU (1) | AU2004218200B2 (da) |
| DE (1) | DE60301980T2 (da) |
| DK (1) | DK1338591T3 (da) |
| EA (1) | EA007948B1 (da) |
| ES (1) | ES2250847T3 (da) |
| HK (1) | HK1086262A1 (da) |
| MY (1) | MY135169A (da) |
| NZ (1) | NZ541422A (da) |
| PL (1) | PL219733B1 (da) |
| SI (1) | SI1338591T1 (da) |
| WO (1) | WO2004078707A2 (da) |
| ZA (1) | ZA200505779B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
| WO2005094793A1 (en) * | 2004-03-29 | 2005-10-13 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing a solid pharmaceutical composition |
| SI21800A (sl) | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
| US7732621B2 (en) * | 2004-12-28 | 2010-06-08 | Dsm Ip Assets B.V. | Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid |
| CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ202903A (en) * | 1981-12-29 | 1988-01-08 | Hoechst Ag | 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions |
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| NL1008302C2 (nl) * | 1998-02-13 | 1999-08-16 | Dsm Nv | Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| DE60301774T2 (de) * | 2003-02-28 | 2006-07-20 | Les Laboratoires Servier | Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
-
2003
- 2003-02-28 DE DE60301980T patent/DE60301980T2/de not_active Expired - Lifetime
- 2003-02-28 SI SI200330107T patent/SI1338591T1/sl unknown
- 2003-02-28 AT AT03290487T patent/ATE307801T1/de active
- 2003-02-28 ES ES03290487T patent/ES2250847T3/es not_active Expired - Lifetime
- 2003-02-28 DK DK03290487T patent/DK1338591T3/da active
- 2003-02-28 EP EP03290487A patent/EP1338591B1/fr not_active Expired - Lifetime
-
2004
- 2004-02-27 AR ARP040100611A patent/AR043411A1/es not_active Application Discontinuation
- 2004-02-27 EA EA200501256A patent/EA007948B1/ru not_active IP Right Cessation
- 2004-02-27 NZ NZ541422A patent/NZ541422A/en not_active IP Right Cessation
- 2004-02-27 MY MYPI20040683A patent/MY135169A/en unknown
- 2004-02-27 US US10/546,967 patent/US7157484B2/en not_active Expired - Fee Related
- 2004-02-27 ZA ZA200505779A patent/ZA200505779B/xx unknown
- 2004-02-27 WO PCT/FR2004/000444 patent/WO2004078707A2/fr active Application Filing
- 2004-02-27 AU AU2004218200A patent/AU2004218200B2/en not_active Ceased
- 2004-02-27 JP JP2006500161A patent/JP4563371B2/ja not_active Expired - Fee Related
- 2004-02-27 PL PL377232A patent/PL219733B1/pl unknown
- 2004-02-27 CN CNB2004800054078A patent/CN100364974C/zh not_active Expired - Fee Related
-
2006
- 2006-05-29 HK HK06106191A patent/HK1086262A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE307801T1 (de) | 2005-11-15 |
| DE60301980D1 (de) | 2005-12-01 |
| ZA200505779B (en) | 2006-09-27 |
| CN1753869A (zh) | 2006-03-29 |
| JP2006519175A (ja) | 2006-08-24 |
| ES2250847T3 (es) | 2006-04-16 |
| NZ541422A (en) | 2008-03-28 |
| EP1338591B1 (fr) | 2005-10-26 |
| US20060167273A1 (en) | 2006-07-27 |
| WO2004078707A2 (fr) | 2004-09-16 |
| MY135169A (en) | 2008-02-29 |
| CN100364974C (zh) | 2008-01-30 |
| DE60301980T2 (de) | 2006-07-27 |
| EP1338591A1 (fr) | 2003-08-27 |
| SI1338591T1 (sl) | 2006-02-28 |
| AR043411A1 (es) | 2005-07-27 |
| HK1086262A1 (en) | 2006-09-15 |
| PL219733B1 (pl) | 2015-07-31 |
| EA007948B1 (ru) | 2007-02-27 |
| JP4563371B2 (ja) | 2010-10-13 |
| AU2004218200B2 (en) | 2009-07-30 |
| WO2004078707A3 (fr) | 2004-10-14 |
| US7157484B2 (en) | 2007-01-02 |
| AU2004218200A1 (en) | 2004-09-16 |
| EA200501256A1 (ru) | 2006-04-28 |
| PL377232A1 (pl) | 2006-01-23 |
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