ATE338766T1 - Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen - Google Patents

Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen

Info

Publication number
ATE338766T1
ATE338766T1 AT03292131T AT03292131T ATE338766T1 AT E338766 T1 ATE338766 T1 AT E338766T1 AT 03292131 T AT03292131 T AT 03292131T AT 03292131 T AT03292131 T AT 03292131T AT E338766 T1 ATE338766 T1 AT E338766T1
Authority
AT
Austria
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Application number
AT03292131T
Other languages
English (en)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of ATE338766T1 publication Critical patent/ATE338766T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT03292131T 2003-08-29 2003-08-29 Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen ATE338766T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03292131A EP1380590B1 (de) 2003-08-29 2003-08-29 Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen ¬2003/26|

Publications (1)

Publication Number Publication Date
ATE338766T1 true ATE338766T1 (de) 2006-09-15

Family

ID=29724623

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03292131T ATE338766T1 (de) 2003-08-29 2003-08-29 Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen

Country Status (20)

Country Link
US (1) US7183308B1 (de)
EP (1) EP1380590B1 (de)
JP (1) JP4331205B2 (de)
CN (1) CN100395264C (de)
AR (1) AR045515A1 (de)
AT (1) ATE338766T1 (de)
AU (1) AU2004270427B2 (de)
CY (1) CY1105790T1 (de)
DE (1) DE60308102T2 (de)
DK (1) DK1380590T3 (de)
EA (1) EA008485B1 (de)
ES (1) ES2272922T3 (de)
HK (1) HK1096409A1 (de)
MY (1) MY139348A (de)
NZ (1) NZ545335A (de)
PL (1) PL211509B1 (de)
PT (1) PT1380590E (de)
SI (1) SI1380590T1 (de)
WO (1) WO2005023841A1 (de)
ZA (1) ZA200601428B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2252633T3 (es) * 2003-08-29 2006-05-16 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus bases farmaceuticamente aceptables.
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
ATE409036T1 (de) 2005-01-06 2008-10-15 Ipca Lab Ltd Verfahren zur synthese von (2s,3as,7as)-1-(s)- alanyl-octahydro-1h-2-carbonsäurederivaten und verwendung in der synthese von perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法
CN112047998B (zh) * 2020-09-07 2024-01-09 上海阿达玛斯试剂有限公司 一种培哚普利的制备方法
CN113980096A (zh) * 2021-11-29 2022-01-28 绍兴市上虞区武汉理工大学高等研究院 一种吨级培哚普利叔丁胺的合成工艺方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
SI1323729T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
ES2240919T3 (es) * 2003-03-12 2005-10-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1371659T3 (da) * 2003-08-29 2005-11-21 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf

Also Published As

Publication number Publication date
DE60308102D1 (de) 2006-10-19
MY139348A (en) 2009-09-30
PL379629A1 (pl) 2006-10-30
CY1105790T1 (el) 2011-02-02
AU2004270427B2 (en) 2008-08-21
HK1096409A1 (en) 2007-06-01
ES2272922T3 (es) 2007-05-01
SI1380590T1 (sl) 2006-12-31
CN1839147A (zh) 2006-09-27
CN100395264C (zh) 2008-06-18
AU2004270427A1 (en) 2005-03-17
EP1380590A1 (de) 2004-01-14
NZ545335A (en) 2009-08-28
JP2007526901A (ja) 2007-09-20
EA200600456A1 (ru) 2006-08-25
DE60308102T2 (de) 2007-06-21
DK1380590T3 (da) 2007-01-08
EA008485B1 (ru) 2007-06-29
JP4331205B2 (ja) 2009-09-16
US20070043103A1 (en) 2007-02-22
US7183308B1 (en) 2007-02-27
PT1380590E (pt) 2006-12-29
WO2005023841A1 (fr) 2005-03-17
ZA200601428B (en) 2007-05-30
PL211509B1 (pl) 2012-05-31
AR045515A1 (es) 2005-11-02
EP1380590B1 (de) 2006-09-06

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