ATE354586T1 - Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen - Google Patents
Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzenInfo
- Publication number
- ATE354586T1 ATE354586T1 AT03292864T AT03292864T ATE354586T1 AT E354586 T1 ATE354586 T1 AT E354586T1 AT 03292864 T AT03292864 T AT 03292864T AT 03292864 T AT03292864 T AT 03292864T AT E354586 T1 ATE354586 T1 AT E354586T1
- Authority
- AT
- Austria
- Prior art keywords
- perindopril
- synthesis
- pharmaceutically acceptable
- acceptable salts
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03292864A EP1420028B1 (de) | 2003-11-19 | 2003-11-19 | Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE354586T1 true ATE354586T1 (de) | 2007-03-15 |
Family
ID=32116380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03292864T ATE354586T1 (de) | 2003-11-19 | 2003-11-19 | Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7208607B1 (de) |
| EP (1) | EP1420028B1 (de) |
| JP (1) | JP4377412B2 (de) |
| KR (1) | KR100863394B1 (de) |
| CN (1) | CN100447152C (de) |
| AR (1) | AR047312A1 (de) |
| AT (1) | ATE354586T1 (de) |
| AU (1) | AU2004295132B2 (de) |
| BR (1) | BRPI0416746B1 (de) |
| CA (1) | CA2546506C (de) |
| CY (1) | CY1106544T1 (de) |
| DE (1) | DE60311942T2 (de) |
| DK (1) | DK1420028T3 (de) |
| EA (1) | EA010102B1 (de) |
| EG (1) | EG26629A (de) |
| ES (1) | ES2282586T3 (de) |
| GE (1) | GEP20084547B (de) |
| MA (1) | MA28144A1 (de) |
| MX (1) | MXPA06005607A (de) |
| MY (1) | MY138550A (de) |
| NO (1) | NO336349B1 (de) |
| NZ (1) | NZ546931A (de) |
| PL (1) | PL210769B1 (de) |
| PT (1) | PT1420028E (de) |
| SI (1) | SI1420028T1 (de) |
| UA (1) | UA83269C2 (de) |
| WO (1) | WO2005054276A1 (de) |
| ZA (1) | ZA200603675B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1380591B1 (de) * | 2003-08-29 | 2005-11-16 | Les Laboratoires Servier | Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen |
| BRPI0418244A (pt) | 2003-12-29 | 2007-04-17 | Sepracor Inc | composto, métodos para aumentar a concentração de d-serina e/ou diminuir a concentração de produtos tóxicos da oxidação de d-serina pela daao em um mamìfero, para tratar a esquizofrenia, para tratar ou prevenir a perda de memória e/ou cognição associadas com o mal de alzheimer, para tratar a ataxia ou para prevenir a perda da função neuronal caracterìstica de doenças neurodegenerativas, para intensificar a aprendizagem, memória e/ou cognição e para tratar dor neuropática, e, composição farmacêutica |
| WO2007006003A2 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| CA2636324C (en) | 2006-01-06 | 2012-03-20 | Sepracor Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| KR101381768B1 (ko) | 2006-01-06 | 2014-04-07 | 선오비온 파마슈티컬스 인코포레이티드 | 테트랄론-기재 모노아민 재흡수 저해제 |
| PT2816024T (pt) | 2006-03-31 | 2017-10-20 | Sunovion Pharmaceuticals Inc | Aminas quirais |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| KR101581289B1 (ko) | 2007-05-31 | 2015-12-31 | 세프라코 아이엔시. | 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민 |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| PH12018502155B1 (en) | 2016-04-20 | 2024-03-27 | Servier Lab | Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid |
| CN112047869B (zh) * | 2020-08-20 | 2021-12-21 | 华南理工大学 | 一种氮杂5,6-并环化合物的合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
-
2003
- 2003-11-19 SI SI200330702T patent/SI1420028T1/sl unknown
- 2003-11-19 DK DK03292864T patent/DK1420028T3/da active
- 2003-11-19 EP EP03292864A patent/EP1420028B1/de not_active Expired - Lifetime
- 2003-11-19 PT PT03292864T patent/PT1420028E/pt unknown
- 2003-11-19 DE DE60311942T patent/DE60311942T2/de not_active Expired - Lifetime
- 2003-11-19 AT AT03292864T patent/ATE354586T1/de active
- 2003-11-19 ES ES03292864T patent/ES2282586T3/es not_active Expired - Lifetime
-
2004
- 2004-11-18 EA EA200600898A patent/EA010102B1/ru not_active IP Right Cessation
- 2004-11-18 CA CA2546506A patent/CA2546506C/fr not_active Expired - Fee Related
- 2004-11-18 PL PL380409A patent/PL210769B1/pl unknown
- 2004-11-18 KR KR1020067011929A patent/KR100863394B1/ko not_active Expired - Fee Related
- 2004-11-18 NZ NZ546931A patent/NZ546931A/en not_active IP Right Cessation
- 2004-11-18 AU AU2004295132A patent/AU2004295132B2/en not_active Ceased
- 2004-11-18 ZA ZA200603675A patent/ZA200603675B/en unknown
- 2004-11-18 AR ARP040104252A patent/AR047312A1/es not_active Application Discontinuation
- 2004-11-18 MX MXPA06005607A patent/MXPA06005607A/es active IP Right Grant
- 2004-11-18 US US10/580,148 patent/US7208607B1/en not_active Expired - Fee Related
- 2004-11-18 JP JP2006540515A patent/JP4377412B2/ja not_active Expired - Fee Related
- 2004-11-18 MY MYPI20044785A patent/MY138550A/en unknown
- 2004-11-18 BR BRPI0416746-5A patent/BRPI0416746B1/pt not_active IP Right Cessation
- 2004-11-18 WO PCT/FR2004/002936 patent/WO2005054276A1/fr not_active Ceased
- 2004-11-18 GE GEAP20049463A patent/GEP20084547B/en unknown
- 2004-11-18 UA UAA200606747A patent/UA83269C2/uk unknown
- 2004-11-18 CN CNB2004800336869A patent/CN100447152C/zh not_active Expired - Fee Related
-
2006
- 2006-05-02 MA MA28993A patent/MA28144A1/fr unknown
- 2006-05-16 EG EGPCTNA2006000459A patent/EG26629A/en active
- 2006-06-06 NO NO20062599A patent/NO336349B1/no not_active IP Right Cessation
-
2007
- 2007-04-26 CY CY20071100562T patent/CY1106544T1/el unknown
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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