PL380409A1 - Proces syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli - Google Patents

Proces syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli

Info

Publication number
PL380409A1
PL380409A1 PL380409A PL38040904A PL380409A1 PL 380409 A1 PL380409 A1 PL 380409A1 PL 380409 A PL380409 A PL 380409A PL 38040904 A PL38040904 A PL 38040904A PL 380409 A1 PL380409 A1 PL 380409A1
Authority
PL
Poland
Prior art keywords
formula
give
reacting
compound
perindopril
Prior art date
Application number
PL380409A
Other languages
English (en)
Other versions
PL210769B1 (pl
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of PL380409A1 publication Critical patent/PL380409A1/pl
Publication of PL210769B1 publication Critical patent/PL210769B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL380409A 2003-11-19 2004-11-18 Sposób otrzymywania perindoprilu i jego farmaceutycznie dopuszczalnych soli oraz związek przejściowy PL210769B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03292864A EP1420028B1 (fr) 2003-11-19 2003-11-19 Pocédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/002936 WO2005054276A1 (fr) 2003-11-19 2004-11-18 Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
PL380409A1 true PL380409A1 (pl) 2007-01-22
PL210769B1 PL210769B1 (pl) 2012-02-29

Family

ID=32116380

Family Applications (1)

Application Number Title Priority Date Filing Date
PL380409A PL210769B1 (pl) 2003-11-19 2004-11-18 Sposób otrzymywania perindoprilu i jego farmaceutycznie dopuszczalnych soli oraz związek przejściowy

Country Status (29)

Country Link
US (1) US7208607B1 (pl)
EP (1) EP1420028B1 (pl)
JP (1) JP4377412B2 (pl)
KR (1) KR100863394B1 (pl)
CN (1) CN100447152C (pl)
AR (1) AR047312A1 (pl)
AT (1) ATE354586T1 (pl)
AU (1) AU2004295132B2 (pl)
BR (1) BRPI0416746B1 (pl)
CA (1) CA2546506C (pl)
CY (1) CY1106544T1 (pl)
DE (1) DE60311942T2 (pl)
DK (1) DK1420028T3 (pl)
EA (1) EA010102B1 (pl)
EG (1) EG26629A (pl)
ES (1) ES2282586T3 (pl)
GE (1) GEP20084547B (pl)
HK (1) HK1096689A1 (pl)
MA (1) MA28144A1 (pl)
MX (1) MXPA06005607A (pl)
MY (1) MY138550A (pl)
NO (1) NO336349B1 (pl)
NZ (1) NZ546931A (pl)
PL (1) PL210769B1 (pl)
PT (1) PT1420028E (pl)
SI (1) SI1420028T1 (pl)
UA (1) UA83269C2 (pl)
WO (1) WO2005054276A1 (pl)
ZA (1) ZA200603675B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE310012T1 (de) * 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
ZA200605383B (en) 2003-12-29 2008-06-25 Sepracor Inc Pyrrole and pyrazole daao inhibitors
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
WO2007081542A2 (en) 2006-01-06 2007-07-19 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
RU2430913C2 (ru) 2006-01-06 2011-10-10 Сепракор Инк. Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина
DK2013835T3 (en) 2006-03-31 2015-12-14 Sunovion Pharmaceuticals Inc Preparation of chiral amides and AMINES
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
BRPI0811639A2 (pt) 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN112047869B (zh) * 2020-08-20 2021-12-21 华南理工大学 一种氮杂5,6-并环化合物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Also Published As

Publication number Publication date
NZ546931A (en) 2010-01-29
EP1420028A3 (fr) 2004-05-26
CN100447152C (zh) 2008-12-31
CY1106544T1 (el) 2012-01-25
ATE354586T1 (de) 2007-03-15
US20070083052A1 (en) 2007-04-12
BRPI0416746B1 (pt) 2018-02-14
MXPA06005607A (es) 2006-08-17
DK1420028T3 (da) 2007-06-18
MA28144A1 (fr) 2006-09-01
JP2008502587A (ja) 2008-01-31
ZA200603675B (en) 2007-09-26
EA010102B1 (ru) 2008-06-30
HK1096689A1 (en) 2007-06-08
PL210769B1 (pl) 2012-02-29
CA2546506A1 (fr) 2005-06-16
BRPI0416746A (pt) 2007-01-16
DE60311942T2 (de) 2007-12-06
PT1420028E (pt) 2007-05-31
WO2005054276A1 (fr) 2005-06-16
NO336349B1 (no) 2015-08-03
EP1420028B1 (fr) 2007-02-21
EA200600898A1 (ru) 2006-10-27
JP4377412B2 (ja) 2009-12-02
KR20060121202A (ko) 2006-11-28
CN1882607A (zh) 2006-12-20
MY138550A (en) 2009-06-30
CA2546506C (fr) 2010-04-06
US7208607B1 (en) 2007-04-24
KR100863394B1 (ko) 2008-10-14
SI1420028T1 (sl) 2007-06-30
AU2004295132B2 (en) 2010-07-15
AR047312A1 (es) 2006-01-18
GEP20084547B (en) 2008-11-25
EP1420028A2 (fr) 2004-05-19
NO20062599L (no) 2006-06-06
UA83269C2 (uk) 2008-06-25
AU2004295132A1 (en) 2005-06-16
DE60311942D1 (de) 2007-04-05
ES2282586T3 (es) 2007-10-16
EG26629A (en) 2014-04-13

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