AR047312A1 - Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables - Google Patents
Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptablesInfo
- Publication number
- AR047312A1 AR047312A1 ARP040104252A ARP040104252A AR047312A1 AR 047312 A1 AR047312 A1 AR 047312A1 AR P040104252 A ARP040104252 A AR P040104252A AR P040104252 A ARP040104252 A AR P040104252A AR 047312 A1 AR047312 A1 AR 047312A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- synthesis
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Reivindicacion 1: Procedimiento para la síntesis del compuesto de formula (1), y de sus sales farmacéuticamente aceptables, caracterizado porque se hace reaccionar el compuesto de formula (2), de configuracion (S), en la cual R representa un átomo de hidrogeno o un grupo de proteccion para la funcion ácido, con el compuesto de formula (3), de configuracion (R), en la cual G representa un átomo de cloro o bromo, o un grupo hidroxi, p-toluensulfoniloxi, metanosulfoniloxi o trifluorometanosulfoniloxi, en presencia de una base para obtener el compuesto de formula (4), en la cual R y G son tal como se han definido anteriormente, que se somete a una reaccion de acoplamiento intramolecular para obtener el compuesto de formula (5), en la cual R y G son tal como se han definido anteriormente, que se hace reaccionar con el compuesto de formula (6), para obtener el compuesto de formula (7), en la cual R es tal como se ha definido anteriormente, que se somete a una reaccion de hidrogenacion catalítica para obtener después de la desproteccion, cuando fuere necesario, el compuesto de formula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03292864A EP1420028B1 (fr) | 2003-11-19 | 2003-11-19 | Pocédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
Publication Number | Publication Date |
---|---|
AR047312A1 true AR047312A1 (es) | 2006-01-18 |
Family
ID=32116380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040104252A AR047312A1 (es) | 2003-11-19 | 2004-11-18 | Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables |
Country Status (29)
Country | Link |
---|---|
US (1) | US7208607B1 (es) |
EP (1) | EP1420028B1 (es) |
JP (1) | JP4377412B2 (es) |
KR (1) | KR100863394B1 (es) |
CN (1) | CN100447152C (es) |
AR (1) | AR047312A1 (es) |
AT (1) | ATE354586T1 (es) |
AU (1) | AU2004295132B2 (es) |
BR (1) | BRPI0416746B1 (es) |
CA (1) | CA2546506C (es) |
CY (1) | CY1106544T1 (es) |
DE (1) | DE60311942T2 (es) |
DK (1) | DK1420028T3 (es) |
EA (1) | EA010102B1 (es) |
EG (1) | EG26629A (es) |
ES (1) | ES2282586T3 (es) |
GE (1) | GEP20084547B (es) |
HK (1) | HK1096689A1 (es) |
MA (1) | MA28144A1 (es) |
MX (1) | MXPA06005607A (es) |
MY (1) | MY138550A (es) |
NO (1) | NO336349B1 (es) |
NZ (1) | NZ546931A (es) |
PL (1) | PL210769B1 (es) |
PT (1) | PT1420028E (es) |
SI (1) | SI1420028T1 (es) |
UA (1) | UA83269C2 (es) |
WO (1) | WO2005054276A1 (es) |
ZA (1) | ZA200603675B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1380591T3 (da) * | 2003-08-29 | 2006-01-23 | Servier Lab | Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf |
US7488747B2 (en) | 2003-12-29 | 2009-02-10 | Sepracor Inc. | Pyrrole and pyrazole DAAO inhibitors |
MX2008000250A (es) | 2005-07-06 | 2008-03-19 | Sepracor Inc | Combinaciones de eszopiclona y trans-4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-n-metil-1-naftalenamina o trans 4-(3,4-diclorofenil)-1, 2,3,4-tetrahidro-1-naftalenamina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y |
CN101394847B (zh) | 2006-01-06 | 2017-05-24 | 塞普拉柯公司 | 作为单胺重摄取抑制剂的环烷基胺类 |
CN101426372A (zh) | 2006-01-06 | 2009-05-06 | 塞普拉柯公司 | 基于四氢萘酮的单胺再摄取抑制剂 |
CA2648121C (en) | 2006-03-31 | 2013-08-06 | Sepracor Inc. | Preparation of chiral amides and amines |
US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
CN101686672A (zh) | 2007-05-31 | 2010-03-31 | 塞普拉柯公司 | 苯基取代的环烷胺作为一元胺再摄取抑制剂 |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
CN112047869B (zh) * | 2020-08-20 | 2021-12-21 | 华南理工大学 | 一种氮杂5,6-并环化合物的合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
-
2003
- 2003-11-19 ES ES03292864T patent/ES2282586T3/es not_active Expired - Lifetime
- 2003-11-19 PT PT03292864T patent/PT1420028E/pt unknown
- 2003-11-19 DK DK03292864T patent/DK1420028T3/da active
- 2003-11-19 SI SI200330702T patent/SI1420028T1/sl unknown
- 2003-11-19 AT AT03292864T patent/ATE354586T1/de active
- 2003-11-19 DE DE60311942T patent/DE60311942T2/de not_active Expired - Lifetime
- 2003-11-19 EP EP03292864A patent/EP1420028B1/fr not_active Expired - Lifetime
-
2004
- 2004-11-18 MY MYPI20044785A patent/MY138550A/en unknown
- 2004-11-18 AR ARP040104252A patent/AR047312A1/es not_active Application Discontinuation
- 2004-11-18 CN CNB2004800336869A patent/CN100447152C/zh not_active Expired - Fee Related
- 2004-11-18 US US10/580,148 patent/US7208607B1/en not_active Expired - Fee Related
- 2004-11-18 GE GEAP20049463A patent/GEP20084547B/en unknown
- 2004-11-18 UA UAA200606747A patent/UA83269C2/uk unknown
- 2004-11-18 AU AU2004295132A patent/AU2004295132B2/en not_active Ceased
- 2004-11-18 EA EA200600898A patent/EA010102B1/ru not_active IP Right Cessation
- 2004-11-18 KR KR1020067011929A patent/KR100863394B1/ko not_active IP Right Cessation
- 2004-11-18 ZA ZA200603675A patent/ZA200603675B/en unknown
- 2004-11-18 JP JP2006540515A patent/JP4377412B2/ja not_active Expired - Fee Related
- 2004-11-18 BR BRPI0416746-5A patent/BRPI0416746B1/pt not_active IP Right Cessation
- 2004-11-18 NZ NZ546931A patent/NZ546931A/en not_active IP Right Cessation
- 2004-11-18 PL PL380409A patent/PL210769B1/pl unknown
- 2004-11-18 MX MXPA06005607A patent/MXPA06005607A/es active IP Right Grant
- 2004-11-18 CA CA2546506A patent/CA2546506C/fr not_active Expired - Fee Related
- 2004-11-18 WO PCT/FR2004/002936 patent/WO2005054276A1/fr active Application Filing
-
2006
- 2006-05-02 MA MA28993A patent/MA28144A1/fr unknown
- 2006-05-16 EG EGPCTNA2006000459A patent/EG26629A/en active
- 2006-06-06 NO NO20062599A patent/NO336349B1/no not_active IP Right Cessation
-
2007
- 2007-02-01 HK HK07101194.5A patent/HK1096689A1/xx not_active IP Right Cessation
- 2007-04-26 CY CY20071100562T patent/CY1106544T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR047312A1 (es) | Procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables | |
PE20071322A1 (es) | Derivados de 2-morfolinopirimidina como inhibidores de fosfatidinoinositol(pi) 3-quinasa | |
PE20030612A1 (es) | Benzoimidazoles | |
AR061811A1 (es) | Procedimiento para la preparacion de asenapina y productos intermedios usados en dicho procedimiento | |
AR062111A1 (es) | Derivados de beta-d-glucopiranosil indol, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes antidiabeticos. | |
PE20040844A1 (es) | Acidos fenilaceticos y derivados como inhibidores de la cox-2 | |
ECSP034460A (es) | Nuevos compuestos heterociclicos, su preparacion y su utilizacion como medicamentos, en especial como antibacterianos | |
UY26276A1 (es) | 1,2,4,5- tetrahidro-benzo (d) azepinas ley 17164 | |
AR070352A1 (es) | Derivado de pirrolopirimidina como inhibidor de la enzima pi3k, un procedimiento de elaboracion del compuesto, una composicion farmaceutica y un agente preventivo o terapeutico en base al compuesto. | |
AR066972A1 (es) | Derivados azapeptidicos | |
ECSP088084A (es) | Derivados de n-(heteroaril)-1-heteroarilalquil-1h-indol-2-carboxamidas, su preparación y su aplicación en terapéutica | |
EA200600621A1 (ru) | Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств | |
AR063449A1 (es) | Proceso quimico para derivados de quinazolina, intermediarios | |
CR9199A (es) | Procedimiento para la produccion de sales de (4,5-dihidroisoxasol-3-il) tiocarboxamidina | |
UY30300A1 (es) | Compuestos triarílicos y sus derivados | |
IL177431A0 (en) | New process for the synthesis of substituted alpha-aminoindan derivatives | |
UY27786A1 (es) | Derivados de isoquinolina. | |
CR10671A (es) | Compuestos azabiciclicos como inhibidores de la recaptacion de monoaminas | |
UY27803A1 (es) | Derivados de benzoxazina y usos de los mismos. | |
GT200300284A (es) | Derivados de 3h-quinazolin-4-ona | |
AR040133A1 (es) | Derivados de n-acilamino bencil eter | |
AR044943A1 (es) | Procedimiento para la sintesis de perindopril y sales farmaceuticamente aceptables del mismo | |
PA8644201A1 (es) | Hexadecasacaridos biotinilados, su preparacion y utilizacion | |
AR044944A1 (es) | Procedimiento par la sintesis de perindopril y sales farmaceuticamente aceptables del mismo | |
AR063775A1 (es) | 2- imidazoles sustituidos, un proceso para su obtencion y medicamento preparado en base al compuesto |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |