AR044943A1 - Procedimiento para la sintesis de perindopril y sales farmaceuticamente aceptables del mismo - Google Patents
Procedimiento para la sintesis de perindopril y sales farmaceuticamente aceptables del mismoInfo
- Publication number
- AR044943A1 AR044943A1 ARP040102276A ARP040102276A AR044943A1 AR 044943 A1 AR044943 A1 AR 044943A1 AR P040102276 A ARP040102276 A AR P040102276A AR P040102276 A ARP040102276 A AR P040102276A AR 044943 A1 AR044943 A1 AR 044943A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- pharmaceutically acceptable
- compound
- synthesis
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento para la síntesis de perindopril de fórmula (1) y de las sales farmacéuticamente aceptables del mismo. Reivindicación 1: Procedimiento para la síntesis de los compuestos de fórmula (1) y las sales farmacéuticamente aceptables de los mismos, caracterizado porque el compuesto de la fórmula (2) se somete a reacción con un compuesto de fórmula (3)en la cual X1 y X2 que pueden ser idénticos o diferentes, representan, cada uno de ellos, un grupo de salida para obtener el compuesto de fórmula (4) que se somete a reacción con un compuesto de fórmula (5) en la cual R representa un átomo e H o un grupo bencilo o alquilo C1-6 lineal o ramificado, o una sal de adición del mismo con un ácido mineral u orgánico, para obtener, después del aislamiento, un compuesto de fórmula (6) en la cual R es tal como ser ha definido anteriormente, que se hidrogena en presencia de un catalizador como ser, por ejemplo, paladio, platino, rodio o níquel, bajo una presión de H que oscila entre 1 y 30 bares, para obtener después de la desprotección de la función ácido, cuando fuere necesario, perindopril de fórmula (1), que se convierte, si se desea, en una sal farmacéuticamente aceptable como ser la sal de terc-butilamina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291600A EP1362864B1 (fr) | 2003-06-30 | 2003-06-30 | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044943A1 true AR044943A1 (es) | 2005-10-12 |
Family
ID=29266055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102276A AR044943A1 (es) | 2003-06-30 | 2004-06-29 | Procedimiento para la sintesis de perindopril y sales farmaceuticamente aceptables del mismo |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7220776B2 (es) |
| EP (1) | EP1362864B1 (es) |
| JP (1) | JP4347342B2 (es) |
| CN (1) | CN100383159C (es) |
| AR (1) | AR044943A1 (es) |
| AT (1) | ATE360638T1 (es) |
| AU (1) | AU2004255899B2 (es) |
| CY (1) | CY1106471T1 (es) |
| DE (1) | DE60313391T2 (es) |
| DK (1) | DK1362864T3 (es) |
| EA (1) | EA009458B1 (es) |
| ES (1) | ES2286393T3 (es) |
| HK (1) | HK1089187A1 (es) |
| MY (1) | MY136938A (es) |
| NZ (1) | NZ544004A (es) |
| PL (1) | PL211491B1 (es) |
| PT (1) | PT1362864E (es) |
| SI (1) | SI1362864T1 (es) |
| WO (1) | WO2005005461A2 (es) |
| ZA (1) | ZA200510324B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1709004A2 (en) | 2003-12-29 | 2006-10-11 | Sepracor Inc. | Pyrrole and pyrazole daao inhibitors |
| EP1987828A1 (en) | 2005-01-06 | 2008-11-05 | IPCA Laboratories Limited | salts of perindopril and their use in the therapy of hypertension |
| WO2007006003A2 (en) | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| RU2430913C2 (ru) | 2006-01-06 | 2011-10-10 | Сепракор Инк. | Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина |
| KR101381768B1 (ko) | 2006-01-06 | 2014-04-07 | 선오비온 파마슈티컬스 인코포레이티드 | 테트랄론-기재 모노아민 재흡수 저해제 |
| ES2643602T3 (es) | 2006-03-31 | 2017-11-23 | Sunovion Pharmaceuticals Inc. | Aminas y quirales |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| JP2008019214A (ja) * | 2006-07-13 | 2008-01-31 | Shiono Chemical Co Ltd | ペリンドプリルまたはその誘導体の製造方法 |
| US7902252B2 (en) | 2007-01-18 | 2011-03-08 | Sepracor, Inc. | Inhibitors of D-amino acid oxidase |
| AU2008259841B2 (en) | 2007-05-31 | 2015-02-05 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
| FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
| CN111116709B (zh) * | 2019-12-31 | 2022-06-24 | 北京鑫开元医药科技有限公司 | 一种培哚普利制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| PT1321471E (pt) * | 2003-03-12 | 2005-07-29 | Servier Lab | Novo processo de sintese do perindopril e dos seus sais aceitaveis sob o ponto de vista farmaceutico |
| DK1367061T3 (da) * | 2003-06-30 | 2006-05-15 | Servier Lab | Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf |
-
2003
- 2003-06-30 SI SI200330844T patent/SI1362864T1/sl unknown
- 2003-06-30 PT PT03291600T patent/PT1362864E/pt unknown
- 2003-06-30 DK DK03291600T patent/DK1362864T3/da active
- 2003-06-30 AT AT03291600T patent/ATE360638T1/de active
- 2003-06-30 ES ES03291600T patent/ES2286393T3/es not_active Expired - Lifetime
- 2003-06-30 DE DE60313391T patent/DE60313391T2/de not_active Expired - Lifetime
- 2003-06-30 EP EP03291600A patent/EP1362864B1/fr not_active Expired - Lifetime
-
2004
- 2004-06-28 EA EA200501900A patent/EA009458B1/ru not_active IP Right Cessation
- 2004-06-28 WO PCT/FR2004/001638 patent/WO2005005461A2/fr active Application Filing
- 2004-06-28 AU AU2004255899A patent/AU2004255899B2/en not_active Ceased
- 2004-06-28 ZA ZA200510324A patent/ZA200510324B/xx unknown
- 2004-06-28 CN CNB2004800163249A patent/CN100383159C/zh not_active Expired - Fee Related
- 2004-06-28 PL PL379630A patent/PL211491B1/pl unknown
- 2004-06-28 NZ NZ544004A patent/NZ544004A/xx not_active IP Right Cessation
- 2004-06-28 JP JP2006515296A patent/JP4347342B2/ja not_active Expired - Fee Related
- 2004-06-28 US US10/562,950 patent/US7220776B2/en not_active Expired - Fee Related
- 2004-06-28 MY MYPI20042539A patent/MY136938A/en unknown
- 2004-06-29 AR ARP040102276A patent/AR044943A1/es not_active Application Discontinuation
-
2006
- 2006-08-30 HK HK06109648A patent/HK1089187A1/xx not_active IP Right Cessation
-
2007
- 2007-05-16 CY CY20071100663T patent/CY1106471T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1362864T3 (da) | 2007-09-17 |
| PT1362864E (pt) | 2007-07-23 |
| CY1106471T1 (el) | 2012-01-25 |
| WO2005005461A3 (fr) | 2005-03-31 |
| AU2004255899A1 (en) | 2005-01-20 |
| DE60313391D1 (de) | 2007-06-06 |
| EA200501900A1 (ru) | 2006-06-30 |
| NZ544004A (en) | 2009-03-31 |
| US7220776B2 (en) | 2007-05-22 |
| JP4347342B2 (ja) | 2009-10-21 |
| PL211491B1 (pl) | 2012-05-31 |
| JP2008500263A (ja) | 2008-01-10 |
| SI1362864T1 (sl) | 2007-08-31 |
| EA009458B1 (ru) | 2007-12-28 |
| EP1362864A1 (fr) | 2003-11-19 |
| EP1362864B1 (fr) | 2007-04-25 |
| CN100383159C (zh) | 2008-04-23 |
| HK1089187A1 (en) | 2006-11-24 |
| DE60313391T2 (de) | 2008-01-17 |
| ES2286393T3 (es) | 2007-12-01 |
| WO2005005461A2 (fr) | 2005-01-20 |
| MY136938A (en) | 2008-11-28 |
| ATE360638T1 (de) | 2007-05-15 |
| ZA200510324B (en) | 2007-03-28 |
| AU2004255899B2 (en) | 2008-03-13 |
| US20060148884A1 (en) | 2006-07-06 |
| CN1805972A (zh) | 2006-07-19 |
| PL379630A1 (pl) | 2006-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |