EA200501900A1 - Новый способ синтеза периндоприла и его фармацевтически приемлемых солей - Google Patents

Новый способ синтеза периндоприла и его фармацевтически приемлемых солей

Info

Publication number
EA200501900A1
EA200501900A1 EA200501900A EA200501900A EA200501900A1 EA 200501900 A1 EA200501900 A1 EA 200501900A1 EA 200501900 A EA200501900 A EA 200501900A EA 200501900 A EA200501900 A EA 200501900A EA 200501900 A1 EA200501900 A1 EA 200501900A1
Authority
EA
Eurasian Patent Office
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
new method
Prior art date
Application number
EA200501900A
Other languages
English (en)
Other versions
EA009458B1 (ru
Inventor
Тьерри Дюбюффе
Жан-Пьер Лекув
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200501900A1 publication Critical patent/EA200501900A1/ru
Publication of EA009458B1 publication Critical patent/EA009458B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

Способ синтеза периндоприла формулы (I)и его фармацевтически приемлемых солей.
EA200501900A 2003-06-30 2004-06-28 Способ синтеза периндоприла и его фармацевтически приемлемых солей EA009458B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03291600A EP1362864B1 (fr) 2003-06-30 2003-06-30 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/001638 WO2005005461A2 (fr) 2003-06-30 2004-06-28 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
EA200501900A1 true EA200501900A1 (ru) 2006-06-30
EA009458B1 EA009458B1 (ru) 2007-12-28

Family

ID=29266055

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501900A EA009458B1 (ru) 2003-06-30 2004-06-28 Способ синтеза периндоприла и его фармацевтически приемлемых солей

Country Status (20)

Country Link
US (1) US7220776B2 (ru)
EP (1) EP1362864B1 (ru)
JP (1) JP4347342B2 (ru)
CN (1) CN100383159C (ru)
AR (1) AR044943A1 (ru)
AT (1) ATE360638T1 (ru)
AU (1) AU2004255899B2 (ru)
CY (1) CY1106471T1 (ru)
DE (1) DE60313391T2 (ru)
DK (1) DK1362864T3 (ru)
EA (1) EA009458B1 (ru)
ES (1) ES2286393T3 (ru)
HK (1) HK1089187A1 (ru)
MY (1) MY136938A (ru)
NZ (1) NZ544004A (ru)
PL (1) PL211491B1 (ru)
PT (1) PT1362864E (ru)
SI (1) SI1362864T1 (ru)
WO (1) WO2005005461A2 (ru)
ZA (1) ZA200510324B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2361862C2 (ru) 2003-12-29 2009-07-20 Сепракор Инк. Пиррольные и пиразольные ингибиторы daao
DE602005009918D1 (de) 2005-01-06 2008-11-06 Ipca Lab Ltd Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
CN101553217A (zh) 2005-07-06 2009-10-07 塞普拉科公司 艾司佐匹克隆与反式4－(3,4－二氯苯基)－1,2,3,4－四氢－n－甲基－1－萘胺或反式4－(3,4－二氯苯基)－1,2,3,4－四氢－1－萘胺的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
NZ569608A (en) 2006-01-06 2011-09-30 Sepracor Inc Tetralone-based monoamine reuptake inhibitors
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
CN101421228B (zh) 2006-03-31 2014-05-21 塞普拉柯公司 手性酰胺和胺的制备
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
JP2008019214A (ja) * 2006-07-13 2008-01-31 Shiono Chemical Co Ltd ペリンドプリルまたはその誘導体の製造方法
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
KR101581289B1 (ko) 2007-05-31 2015-12-31 세프라코 아이엔시. 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN111116709B (zh) * 2019-12-31 2022-06-24 北京鑫开元医药科技有限公司 一种培哚普利制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
SI1321471T1 (ru) * 2003-03-12 2005-08-31 Servier Lab
DE60303101T2 (de) * 2003-06-30 2006-09-28 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen

Also Published As

Publication number Publication date
MY136938A (en) 2008-11-28
WO2005005461A2 (fr) 2005-01-20
DE60313391T2 (de) 2008-01-17
CN100383159C (zh) 2008-04-23
EA009458B1 (ru) 2007-12-28
CY1106471T1 (el) 2012-01-25
HK1089187A1 (en) 2006-11-24
US20060148884A1 (en) 2006-07-06
DK1362864T3 (da) 2007-09-17
SI1362864T1 (sl) 2007-08-31
JP2008500263A (ja) 2008-01-10
ATE360638T1 (de) 2007-05-15
NZ544004A (en) 2009-03-31
ES2286393T3 (es) 2007-12-01
JP4347342B2 (ja) 2009-10-21
PL379630A1 (pl) 2006-10-30
AR044943A1 (es) 2005-10-12
WO2005005461A3 (fr) 2005-03-31
AU2004255899A1 (en) 2005-01-20
EP1362864A1 (fr) 2003-11-19
US7220776B2 (en) 2007-05-22
PT1362864E (pt) 2007-07-23
DE60313391D1 (de) 2007-06-06
CN1805972A (zh) 2006-07-19
AU2004255899B2 (en) 2008-03-13
ZA200510324B (en) 2007-03-28
PL211491B1 (pl) 2012-05-31
EP1362864B1 (fr) 2007-04-25

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU