CR7950A - Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas - Google Patents
Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinasInfo
- Publication number
- CR7950A CR7950A CR7950A CR7950A CR7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A CR 7950 A CR7950 A CR 7950A
- Authority
- CR
- Costa Rica
- Prior art keywords
- preparation
- cianoquinolines
- 2butenoil
- 4amino
- chlorine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
La invencion proporciona un compuesto de la formula (I) en donde S1 y S2 son cada uno independientemente hidrogeno, alquilo, alquelino, alquilino, aralquilo, arilo sustituido o no sustituido, y S1 y S2 conjuntamente con el nitrogeno al cual estos estan enlazados forman un heteroarilo que contiene nitrogeno y una sal farmaceuticamente aceptable del mismo; un metodo para la preparacion del compuesto de la formula (I) y el uso del compuesto de la formula (I) en la preparacion de las 3- cianoquinolinas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44147003P | 2003-01-21 | 2003-01-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR7950A true CR7950A (es) | 2006-05-30 |
Family
ID=32825162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR7950A CR7950A (es) | 2003-01-21 | 2005-08-19 | Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas |
Country Status (15)
Country | Link |
---|---|
US (1) | US7126025B2 (es) |
EP (1) | EP1585479A2 (es) |
CN (1) | CN100537518C (es) |
AR (1) | AR042877A1 (es) |
AU (1) | AU2004207475A1 (es) |
CA (1) | CA2514550A1 (es) |
CL (2) | CL2004000016A1 (es) |
CR (1) | CR7950A (es) |
EC (1) | ECSP055974A (es) |
MX (1) | MXPA05008876A (es) |
NO (1) | NO20053890L (es) |
RU (1) | RU2345984C2 (es) |
SG (1) | SG166678A1 (es) |
TW (1) | TW200418763A (es) |
WO (1) | WO2004066919A2 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
CL2004000016A1 (es) | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
BRPI0520812A2 (pt) * | 2004-01-16 | 2009-10-06 | Wyeth Corp | método para preparar um composto de quinolina 4-substituìda, e, composto |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
KR101313702B1 (ko) | 2005-02-03 | 2013-10-04 | 와이어쓰 | 제피티니브 및/또는 에를로티니브 내성암 치료용 약제학적 조성물 |
CN101180269A (zh) * | 2005-05-25 | 2008-05-14 | 惠氏公司 | 制备3-氰基-喹啉的方法和由其制得的中间体 |
WO2006127207A1 (en) * | 2005-05-25 | 2006-11-30 | Wyeth | Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof |
WO2006127203A2 (en) * | 2005-05-25 | 2006-11-30 | Wyeth | Methods of synthesizing 6-alkylaminoquinoline derivatives |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP3488866A1 (en) | 2005-11-04 | 2019-05-29 | Wyeth LLC | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
WO2007054550A1 (en) | 2005-11-11 | 2007-05-18 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
EP3443961B1 (en) | 2008-06-17 | 2020-10-28 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
BRPI0916694B1 (pt) | 2008-08-04 | 2021-06-08 | Wyeth Llc | uso de neratinibe em combinação com capecitabina para tratar câncer de mama metastático de erbb-2 positivo, kit e produto compreendendo os mesmos |
WO2010048477A2 (en) * | 2008-10-24 | 2010-04-29 | Wyeth Llc | Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates |
AU2009315603B2 (en) * | 2008-11-17 | 2013-08-01 | Novartis Ag | Enantioselective synthesis of gamma-amino-alpha,beta-unsaturated carboxylic acid derivatives |
CA2755789C (en) | 2009-04-06 | 2016-01-19 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
JP5622842B2 (ja) * | 2009-05-14 | 2014-11-12 | コーロン ライフ サイエンス インク | アルキルアミン誘導体の製造方法 |
JP5963672B2 (ja) | 2009-07-06 | 2016-08-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Bibw2992、その塩及びこの活性成分を含む固体医薬製剤の乾燥方法 |
EP2498751B1 (en) | 2009-11-09 | 2019-04-03 | Wyeth LLC | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
CN102731395B (zh) * | 2011-04-15 | 2015-02-04 | 中国科学院上海药物研究所 | 抗肿瘤药物来那替尼的中间体及其制备与应用 |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
CN104926669A (zh) * | 2014-03-18 | 2015-09-23 | 江苏豪森医药集团连云港宏创医药有限公司 | 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法 |
WO2015186065A1 (en) | 2014-06-02 | 2015-12-10 | Sun Pharmaceutical Industries Limited | Process for the preparation of 4-dimethylaminocrotonic acid |
CN105439879B (zh) * | 2014-08-07 | 2018-08-10 | 天津法莫西医药科技有限公司 | 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法 |
CN105669479B (zh) * | 2015-12-31 | 2018-04-13 | 重庆威鹏药业有限公司 | 一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法 |
EP3447051B1 (en) * | 2016-04-28 | 2021-12-15 | Jiangsu Hengrui Medicine Co., Ltd. | Method for preparing tyrosine kinase inhibitor and derivative thereof |
AU2018351539A1 (en) | 2017-10-18 | 2020-05-28 | Jiangsu Hengrui Medicine Co., Ltd. | Preparation method for tyrosine kinase inhibitor and intermediate thereof |
CN111217850B (zh) * | 2019-01-31 | 2023-05-26 | 微宏先进材料公司 | 硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池 |
CN112679473B (zh) * | 2019-10-18 | 2024-03-05 | 四川科伦药物研究院有限公司 | 来那替尼中间体晶体、制备方法及其用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4194050A (en) | 1976-04-30 | 1980-03-18 | Sumitomo Chemical Company, Limited | Process for producing an enamide |
US4195021A (en) | 1977-10-26 | 1980-03-25 | Eli Lilly And Company | 1,3-Disubstituted 2-azetidinone antibitotics |
US4193983A (en) | 1978-05-16 | 1980-03-18 | Syva Company | Labeled liposome particle compositions and immunoassays therewith |
BE897134A (fr) | 1983-06-24 | 1983-12-27 | Solvay | Dienes polysubstitues |
US4478959A (en) | 1983-09-29 | 1984-10-23 | Air Products And Chemicals, Inc. | Amino and amido divalent metal carboxylates useful as catalysts for polyurethane formulations |
DE3347659A1 (de) | 1983-12-31 | 1985-07-11 | Bayer Ag, 5090 Leverkusen | Neue lackloesungen auf der basis von hydantoingruppen enthaltenden polymeren |
US4664825A (en) | 1984-10-25 | 1987-05-12 | The Lubrizol Corporation | Sulfurized compositions and lubricants containing them |
CA2038633A1 (en) | 1990-03-20 | 1991-09-21 | Yoshimi Tsuchiya | Substituted amine derivatives having anti-hyperlipemia activity |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
CL2004000016A1 (es) | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
-
2004
- 2004-01-05 CL CL200400016A patent/CL2004000016A1/es unknown
- 2004-01-12 TW TW093100676A patent/TW200418763A/zh unknown
- 2004-01-14 AR ARP040100092A patent/AR042877A1/es unknown
- 2004-01-15 US US10/758,187 patent/US7126025B2/en not_active Expired - Fee Related
- 2004-01-16 CN CNB2004800077239A patent/CN100537518C/zh not_active Expired - Fee Related
- 2004-01-16 RU RU2005126418/04A patent/RU2345984C2/ru not_active IP Right Cessation
- 2004-01-16 CA CA002514550A patent/CA2514550A1/en not_active Abandoned
- 2004-01-16 WO PCT/US2004/001133 patent/WO2004066919A2/en active Application Filing
- 2004-01-16 SG SG200704889-5A patent/SG166678A1/en unknown
- 2004-01-16 EP EP04702974A patent/EP1585479A2/en not_active Withdrawn
- 2004-01-16 AU AU2004207475A patent/AU2004207475A1/en not_active Abandoned
- 2004-01-16 MX MXPA05008876A patent/MXPA05008876A/es active IP Right Grant
-
2005
- 2005-08-19 CR CR7950A patent/CR7950A/es not_active Application Discontinuation
- 2005-08-19 NO NO20053890A patent/NO20053890L/no not_active Application Discontinuation
- 2005-08-22 EC EC2005005974A patent/ECSP055974A/es unknown
-
2007
- 2007-05-07 CL CL2007001286A patent/CL2007001286A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20040162442A1 (en) | 2004-08-19 |
SG166678A1 (en) | 2010-12-29 |
US7126025B2 (en) | 2006-10-24 |
TW200418763A (en) | 2004-10-01 |
CN100537518C (zh) | 2009-09-09 |
EP1585479A2 (en) | 2005-10-19 |
NO20053890L (no) | 2005-10-20 |
MXPA05008876A (es) | 2005-10-05 |
NO20053890D0 (no) | 2005-08-19 |
CA2514550A1 (en) | 2004-08-12 |
CL2007001286A1 (es) | 2008-01-25 |
CL2004000016A1 (es) | 2005-04-15 |
ECSP055974A (es) | 2006-01-16 |
CN1761644A (zh) | 2006-04-19 |
RU2005126418A (ru) | 2006-01-27 |
AR042877A1 (es) | 2005-07-06 |
WO2004066919A2 (en) | 2004-08-12 |
WO2004066919A3 (en) | 2005-01-27 |
AU2004207475A1 (en) | 2004-08-12 |
RU2345984C2 (ru) | 2009-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal (granting procedure) |