MXPA05008876A - Sintesis de los cloruros de 4-amino-butenoilo y su uso en la preparacion de 3-cianoquinolinas. - Google Patents

Sintesis de los cloruros de 4-amino-butenoilo y su uso en la preparacion de 3-cianoquinolinas.

Info

Publication number
MXPA05008876A
MXPA05008876A MXPA05008876A MXPA05008876A MXPA05008876A MX PA05008876 A MXPA05008876 A MX PA05008876A MX PA05008876 A MXPA05008876 A MX PA05008876A MX PA05008876 A MXPA05008876 A MX PA05008876A MX PA05008876 A MXPA05008876 A MX PA05008876A
Authority
MX
Mexico
Prior art keywords
preparation
4amino
butenoyl
chlorides
synthesis
Prior art date
Application number
MXPA05008876A
Other languages
English (en)
Inventor
Leo Considine John
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32825162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA05008876(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA05008876A publication Critical patent/MXPA05008876A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Abstract

La invencion proporciona un compuesto de la Formula (I) en donde S1 y S2 son cada uno independientemente hidrogeno, alquilo, alquenilo, alquinilo, aralquilo, arilo sustituido o no sustituido, y S1 y S2 conjuntamente con el nitrogeno al cual estos estan enlazados forman un heteroarilo que contiene nitrogeno y una sal farmaceuticamente aceptable del mismo; un metodo para la preparacion del compuesto de la Formula (I) y el uso del compuesto de la Formula (I) en la preparacion de las 3-cianoquinolinas.
MXPA05008876A 2003-01-21 2004-01-16 Sintesis de los cloruros de 4-amino-butenoilo y su uso en la preparacion de 3-cianoquinolinas. MXPA05008876A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44147003P 2003-01-21 2003-01-21
PCT/US2004/001133 WO2004066919A2 (en) 2003-01-21 2004-01-16 Synthesis of 4amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

Publications (1)

Publication Number Publication Date
MXPA05008876A true MXPA05008876A (es) 2005-10-05

Family

ID=32825162

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008876A MXPA05008876A (es) 2003-01-21 2004-01-16 Sintesis de los cloruros de 4-amino-butenoilo y su uso en la preparacion de 3-cianoquinolinas.

Country Status (15)

Country Link
US (1) US7126025B2 (es)
EP (1) EP1585479A2 (es)
CN (1) CN100537518C (es)
AR (1) AR042877A1 (es)
AU (1) AU2004207475A1 (es)
CA (1) CA2514550A1 (es)
CL (2) CL2004000016A1 (es)
CR (1) CR7950A (es)
EC (1) ECSP055974A (es)
MX (1) MXPA05008876A (es)
NO (1) NO20053890L (es)
RU (1) RU2345984C2 (es)
SG (1) SG166678A1 (es)
TW (1) TW200418763A (es)
WO (1) WO2004066919A2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
CA2553729A1 (en) * 2004-01-16 2005-08-04 Wyeth Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
CN113975393A (zh) 2005-02-03 2022-01-28 综合医院公司 治疗吉非替尼耐药性癌症的方法
CN101203494A (zh) * 2005-05-25 2008-06-18 惠氏公司 合成经取代3-氰基喹啉和其中间物的方法
MX2007014773A (es) * 2005-05-25 2008-02-20 Wyeth Corp Metodo para preparar 3-ciano-quinolinas e intermedios hechos de esta forma.
CA2608589A1 (en) * 2005-05-25 2006-11-30 Wyeth Methods of synthesizing 6-alkylaminoquinoline derivatives
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20070104721A1 (en) 2005-11-04 2007-05-10 Wyeth Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
JP5688877B2 (ja) 2005-11-11 2015-03-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌疾患の治療用キナゾリン誘導体
GEP20135728B (en) 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
WO2010008744A2 (en) 2008-06-17 2010-01-21 Wyeth Antineoplastic combinations containing hki-272 and vinorelbine
MX2011001318A (es) 2008-08-04 2011-03-04 Wyeth Llc Combinaciones antineoplasicas de 4-anilino-3-cianoquinolinas y capecitabina.
WO2010048477A2 (en) * 2008-10-24 2010-04-29 Wyeth Llc Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates
WO2010055162A1 (en) * 2008-11-17 2010-05-20 Novartis Ag ENANTIOSELECTIVE SYNTHESIS OF γ-AMINO-α,β-UNSATURATED CARBOXYLIC ACID DERIVATIVES
RU2011139363A (ru) 2009-04-06 2013-05-20 ВАЙЕТ ЭлЭлСи Схема лечения рака молочной железы с использованием нератиниба
JP5622842B2 (ja) * 2009-05-14 2014-11-12 コーロン ライフ サイエンス インク アルキルアミン誘導体の製造方法
LT2451445T (lt) 2009-07-06 2019-06-25 Boehringer Ingelheim International Gmbh Bibw2992, jo druskų ir kietų farmacinių kompozicijų, apimančių šį aktyvųjį ingredientą, džiovinimo būdas
CN102724962B (zh) 2009-11-09 2017-05-17 惠氏有限责任公司 包衣药物球状体及其用于消除或减少病症比如呕吐和腹泻的用途
CN102731395B (zh) * 2011-04-15 2015-02-04 中国科学院上海药物研究所 抗肿瘤药物来那替尼的中间体及其制备与应用
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN104926669A (zh) * 2014-03-18 2015-09-23 江苏豪森医药集团连云港宏创医药有限公司 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法
US9758471B2 (en) 2014-06-02 2017-09-12 Sun Pharmaceutical Industries Limited Process for the preparation of 4-dimethylaminocrotonic acid
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105669479B (zh) * 2015-12-31 2018-04-13 重庆威鹏药业有限公司 一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法
CN108290867B (zh) 2016-04-28 2022-02-08 江苏恒瑞医药股份有限公司 一种制备酪氨酸激酶抑制剂及其衍生物的方法
US11407734B2 (en) 2017-10-18 2022-08-09 Jiangsu Hengrui Medicine Co., Ltd. Preparation method for tyrosine kinase inhibitor and intermediate thereof
CN111217850B (zh) * 2019-01-31 2023-05-26 微宏先进材料公司 硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池
CN112679473B (zh) * 2019-10-18 2024-03-05 四川科伦药物研究院有限公司 来那替尼中间体晶体、制备方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194050A (en) 1976-04-30 1980-03-18 Sumitomo Chemical Company, Limited Process for producing an enamide
US4195021A (en) 1977-10-26 1980-03-25 Eli Lilly And Company 1,3-Disubstituted 2-azetidinone antibitotics
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
BE897134A (fr) 1983-06-24 1983-12-27 Solvay Dienes polysubstitues
US4478959A (en) 1983-09-29 1984-10-23 Air Products And Chemicals, Inc. Amino and amido divalent metal carboxylates useful as catalysts for polyurethane formulations
DE3347659A1 (de) 1983-12-31 1985-07-11 Bayer Ag, 5090 Leverkusen Neue lackloesungen auf der basis von hydantoingruppen enthaltenden polymeren
US4664825A (en) 1984-10-25 1987-05-12 The Lubrizol Corporation Sulfurized compositions and lubricants containing them
CA2038633A1 (en) 1990-03-20 1991-09-21 Yoshimi Tsuchiya Substituted amine derivatives having anti-hyperlipemia activity
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.

Also Published As

Publication number Publication date
AR042877A1 (es) 2005-07-06
US7126025B2 (en) 2006-10-24
RU2005126418A (ru) 2006-01-27
TW200418763A (en) 2004-10-01
US20040162442A1 (en) 2004-08-19
ECSP055974A (es) 2006-01-16
RU2345984C2 (ru) 2009-02-10
AU2004207475A1 (en) 2004-08-12
NO20053890L (no) 2005-10-20
CL2007001286A1 (es) 2008-01-25
SG166678A1 (en) 2010-12-29
EP1585479A2 (en) 2005-10-19
NO20053890D0 (no) 2005-08-19
CA2514550A1 (en) 2004-08-12
CL2004000016A1 (es) 2005-04-15
WO2004066919A3 (en) 2005-01-27
WO2004066919A2 (en) 2004-08-12
CN100537518C (zh) 2009-09-09
CR7950A (es) 2006-05-30
CN1761644A (zh) 2006-04-19

Similar Documents

Publication Publication Date Title
MXPA05008876A (es) Sintesis de los cloruros de 4-amino-butenoilo y su uso en la preparacion de 3-cianoquinolinas.
WO2005123731A3 (en) Pyrrolopyridine derivatives and their use as crth2 antagonists
EP1775289A4 (en) NEW IMIDAZOLIDINE DERIVATIVES
MX2007007098A (es) Derivados de pirrol que tienen actividad antagonista del receptor crth2.
TW200740752A (en) 4-Biarylyl-1-phenylazetidin-2-ones
MY150289A (en) Derivatives of indole-2-carboxamides and of azaindole-2-carboxamides substituted with a silanyl group, preparation thereof and therapeutic use thereof
HK1111999A1 (en) Spiroketal derivative and use thereof as diabetic medicine
MX2009010246A (es) Derivados de 8-oxi-quinolina como moduladores del receptor bradiquinina b2.
MY140873A (en) Novel pyridine derivative and pyrimidine derivative (3)
MXPA05009985A (es) Ligandos de receptores de canabinoides.
MXPA05012248A (es) Fenil quinolinas y su uso como moduladores del receptor de estrogeno.
UA84712C2 (en) N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
MXPA05013474A (es) Derivados de quinolilamida como antagonistas de ccr-5.
MY143353A (en) Diazole derivatives
TW200738667A (en) Preparation method for dioxan-2-ylalkylcarbamate derivatives and intermediate thereof
SE0302192D0 (sv) Novel compounds
JO2413B1 (en) Benzoxazine derivatives and their use
TW200626145A (en) Heterocyclic compounds and thrombopoietin receptor activators
AP2002002616A0 (en) Antidibetic agents
MY186650A (en) Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives
UA86013C2 (ru) Производные арилалкилкарбаматов, их получение и применение в лечении
RS20060239A (en) Arylalkylcarbamate derivatives, preparation method thereof and use of same in therapeutics
SG145570A1 (en) 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents
IL166057A0 (en) Urea-substituted and urethane-substituted acylureas methods for the production thereof and their useas medicaments
MXPA04000036A (es) Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht.

Legal Events

Date Code Title Description
FG Grant or registration