SG166678A1 - Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines - Google Patents

Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines

Info

Publication number
SG166678A1
SG166678A1 SG200704889-5A SG2007048895A SG166678A1 SG 166678 A1 SG166678 A1 SG 166678A1 SG 2007048895 A SG2007048895 A SG 2007048895A SG 166678 A1 SG166678 A1 SG 166678A1
Authority
SG
Singapore
Prior art keywords
preparation
cholrides
4amino
butenoyl
synthesis
Prior art date
Application number
SG200704889-5A
Other languages
English (en)
Inventor
John Leo Considine
Sylvain Daigneault
Chew Warren
Silvio Iera
Scott Mason Duncan
Ren Jianxin
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32825162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG166678(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of SG166678A1 publication Critical patent/SG166678A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
SG200704889-5A 2003-01-21 2004-01-16 Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines SG166678A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44147003P 2003-01-21 2003-01-21

Publications (1)

Publication Number Publication Date
SG166678A1 true SG166678A1 (en) 2010-12-29

Family

ID=32825162

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200704889-5A SG166678A1 (en) 2003-01-21 2004-01-16 Synthesis of 4amino-2-butenoyl cholrides and their use in the preparation of 3-cyano quinolines

Country Status (15)

Country Link
US (1) US7126025B2 (es)
EP (1) EP1585479A2 (es)
CN (1) CN100537518C (es)
AR (1) AR042877A1 (es)
AU (1) AU2004207475A1 (es)
CA (1) CA2514550A1 (es)
CL (2) CL2004000016A1 (es)
CR (1) CR7950A (es)
EC (1) ECSP055974A (es)
MX (1) MXPA05008876A (es)
NO (1) NO20053890L (es)
RU (1) RU2345984C2 (es)
SG (1) SG166678A1 (es)
TW (1) TW200418763A (es)
WO (1) WO2004066919A2 (es)

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UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
CA2553729A1 (en) * 2004-01-16 2005-08-04 Wyeth Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof
WO2006044687A2 (en) 2004-10-15 2006-04-27 Takeda San Diego, Inc. Kinase inhibitors
CN102886045A (zh) 2005-02-03 2013-01-23 综合医院公司 治疗吉非替尼耐药性癌症的方法
RU2007143161A (ru) * 2005-05-25 2009-07-10 Вайет (Us) Способы синтеза замещенных 3-цианохинов и их продуктов
BRPI0610144A2 (pt) * 2005-05-25 2010-06-01 Wyeth Corp método de preparar um 3-cianoquinolina substituìda; composto representado pela fórmula i; e composto, representado pela fórmula ii
JP2008542266A (ja) * 2005-05-25 2008-11-27 ワイス ６−アルキルアミノキノリン誘導体の合成方法
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
KR101354828B1 (ko) 2005-11-04 2014-02-18 와이어쓰 엘엘씨 ｍＴＯＲ 저해자, 헤르셉틴, 및/또는 ＨＫＩ-272의항신생물성 조합
WO2007054550A1 (en) 2005-11-11 2007-05-18 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
EP3135285B1 (en) 2008-06-17 2018-08-15 Wyeth LLC Antineoplastic combinations containing hki-272 and vinorelbine
EP2326329B1 (en) 2008-08-04 2017-01-11 Wyeth LLC Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
WO2010048477A2 (en) * 2008-10-24 2010-04-29 Wyeth Llc Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates
AU2009315603B2 (en) * 2008-11-17 2013-08-01 Novartis Ag Enantioselective synthesis of gamma-amino-alpha,beta-unsaturated carboxylic acid derivatives
DK3000467T3 (da) 2009-04-06 2023-03-27 Wyeth Llc Behandling med neratinib mod brystkræft
JP5622842B2 (ja) * 2009-05-14 2014-11-12 コーロン ライフ サイエンス インク アルキルアミン誘導体の製造方法
SI2451445T1 (sl) 2009-07-06 2019-07-31 Boehringer Ingelheim International Gmbh Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino
ES2729677T3 (es) 2009-11-09 2019-11-05 Wyeth Llc Esferoides de fármacos recubiertos y sus usos para eliminar o reducir condiciones, como la emesis y la diarrea
CN102731395B (zh) * 2011-04-15 2015-02-04 中国科学院上海药物研究所 抗肿瘤药物来那替尼的中间体及其制备与应用
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN104926669A (zh) * 2014-03-18 2015-09-23 江苏豪森医药集团连云港宏创医药有限公司 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法
EP3148977A4 (en) 2014-06-02 2018-01-31 Sun Pharmaceutical Industries Ltd Process for the preparation of 4-dimethylaminocrotonic acid
CN105439879B (zh) * 2014-08-07 2018-08-10 天津法莫西医药科技有限公司 一种反式-4-二甲胺基巴豆酸盐酸盐的制备方法
CN105669479B (zh) * 2015-12-31 2018-04-13 重庆威鹏药业有限公司 一锅法制备高纯度反式‑4‑二甲基胺基巴豆酸盐酸盐的方法
DK3447051T3 (da) * 2016-04-28 2022-01-17 Jiangsu Hengrui Medicine Co Fremgangsmåde til fremstilling af tyrosinkinaseinhibitor og derivat deraf
MX2020004034A (es) 2017-10-18 2020-08-13 Jiangsu Hengrui Medicine Co Metodo de preparacion para un inhibidor de tirosina cinasa e intermediario del mismo.
CN111217850B (zh) * 2019-01-31 2023-05-26 微宏先进材料公司 硅基酯类化合物制备方法、硅基酯类化合物、包含其的电解液及二次电池
CN112679473B (zh) * 2019-10-18 2024-03-05 四川科伦药物研究院有限公司 来那替尼中间体晶体、制备方法及其用途

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US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.

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Title
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 6,7-DISUBSTITUTED 4- ANILINOQUINOLINE-3-CARBONITRILES.. THE DESIGN OF AN ORALLY ACTIVE, IRREVERSIBLE *

Also Published As

Publication number Publication date
CR7950A (es) 2006-05-30
AU2004207475A1 (en) 2004-08-12
ECSP055974A (es) 2006-01-16
CL2004000016A1 (es) 2005-04-15
RU2345984C2 (ru) 2009-02-10
NO20053890D0 (no) 2005-08-19
TW200418763A (en) 2004-10-01
NO20053890L (no) 2005-10-20
CL2007001286A1 (es) 2008-01-25
US20040162442A1 (en) 2004-08-19
CN100537518C (zh) 2009-09-09
WO2004066919A2 (en) 2004-08-12
CA2514550A1 (en) 2004-08-12
RU2005126418A (ru) 2006-01-27
US7126025B2 (en) 2006-10-24
WO2004066919A3 (en) 2005-01-27
AR042877A1 (es) 2005-07-06
CN1761644A (zh) 2006-04-19
EP1585479A2 (en) 2005-10-19
MXPA05008876A (es) 2005-10-05

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