MX2020004034A - Metodo de preparacion para un inhibidor de tirosina cinasa e intermediario del mismo. - Google Patents

Metodo de preparacion para un inhibidor de tirosina cinasa e intermediario del mismo.

Info

Publication number
MX2020004034A
MX2020004034A MX2020004034A MX2020004034A MX2020004034A MX 2020004034 A MX2020004034 A MX 2020004034A MX 2020004034 A MX2020004034 A MX 2020004034A MX 2020004034 A MX2020004034 A MX 2020004034A MX 2020004034 A MX2020004034 A MX 2020004034A
Authority
MX
Mexico
Prior art keywords
preparation
tyrosine kinase
kinase inhibitor
specifically
reaction conditions
Prior art date
Application number
MX2020004034A
Other languages
English (en)
Inventor
Long Zhang
Peng Zhang
Zhenjun Qiu
Guobing Feng
Yongxing Cao
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2020004034A publication Critical patent/MX2020004034A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Se proporciona un método de preparación para un inhibidor de tirosina cinasa y un intermediario del mismo; específicamente, se proporciona un método de preparación para un compuesto de cianoquinolina; el método tiene un alto rendimiento, buena pureza del producto y condiciones de reacción moderadas.
MX2020004034A 2017-10-18 2018-10-17 Metodo de preparacion para un inhibidor de tirosina cinasa e intermediario del mismo. MX2020004034A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710978352 2017-10-18
PCT/CN2018/110615 WO2019076316A1 (zh) 2017-10-18 2018-10-17 一种酪氨酸激酶抑制剂及其中间体的制备方法

Publications (1)

Publication Number Publication Date
MX2020004034A true MX2020004034A (es) 2020-08-13

Family

ID=66174311

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004034A MX2020004034A (es) 2017-10-18 2018-10-17 Metodo de preparacion para un inhibidor de tirosina cinasa e intermediario del mismo.

Country Status (11)

Country Link
US (1) US11407734B2 (es)
EP (1) EP3699177A4 (es)
JP (1) JP2020537650A (es)
KR (1) KR20200072491A (es)
CN (1) CN110770231B (es)
AU (1) AU2018351539A1 (es)
BR (1) BR112020007424A2 (es)
CA (1) CA3079277A1 (es)
MX (1) MX2020004034A (es)
TW (1) TWI691495B (es)
WO (1) WO2019076316A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112279838B (zh) * 2020-10-29 2021-07-13 苏州富士莱医药股份有限公司 一种吡咯替尼的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
CA2535385A1 (en) 2003-08-19 2005-03-03 Wyeth Holdings Corporation Process for the preparation of 4-amino-3-quinolinecarbonitriles
RU2007139544A (ru) * 2005-05-25 2009-06-27 Вайет (Us) Способ получения 3-цианохинолинов и промежуточные соединения, полученные согласно данному способу
US7553855B2 (en) * 2006-05-12 2009-06-30 Vertex Pharmaceuticals Incorporated Compositions of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
CN102020639A (zh) * 2009-09-14 2011-04-20 上海恒瑞医药有限公司 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用
CN102675287A (zh) * 2011-03-11 2012-09-19 江苏恒瑞医药股份有限公司 (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用
CN105330646B (zh) * 2015-12-04 2019-05-24 上海勋和医药科技有限公司 一种抗肿瘤药马来酸来那替尼的制备方法

Also Published As

Publication number Publication date
EP3699177A4 (en) 2021-05-19
US20200239443A1 (en) 2020-07-30
CA3079277A1 (en) 2019-04-25
WO2019076316A1 (zh) 2019-04-25
US11407734B2 (en) 2022-08-09
RU2020115609A (ru) 2021-11-19
TWI691495B (zh) 2020-04-21
CN110770231A (zh) 2020-02-07
KR20200072491A (ko) 2020-06-22
AU2018351539A1 (en) 2020-05-28
CN110770231B (zh) 2022-11-22
JP2020537650A (ja) 2020-12-24
EP3699177A1 (en) 2020-08-26
RU2020115609A3 (es) 2022-02-28
TW201917125A (zh) 2019-05-01
BR112020007424A2 (pt) 2020-12-08

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