ECSP109987A - Métodos y compuestos útiles para preparar inhibidores del co-transportador 2 sodio glucosa - Google Patents
Métodos y compuestos útiles para preparar inhibidores del co-transportador 2 sodio glucosaInfo
- Publication number
- ECSP109987A ECSP109987A EC2010009987A ECSP109987A ECSP109987A EC SP109987 A ECSP109987 A EC SP109987A EC 2010009987 A EC2010009987 A EC 2010009987A EC SP109987 A ECSP109987 A EC SP109987A EC SP109987 A ECSP109987 A EC SP109987A
- Authority
- EC
- Ecuador
- Prior art keywords
- glucose
- methods
- useful compounds
- transporter
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se divulgan métodos de síntesis de inhibidores del co-transportador 2 sodio glucosa, así como también compuestos útiles para esto. Los compuestos de la fórmula (I) son inhibidores particulares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95212207P | 2007-07-26 | 2007-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP109987A true ECSP109987A (es) | 2010-03-31 |
Family
ID=39877996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2010009987A ECSP109987A (es) | 2007-07-26 | 2010-02-23 | Métodos y compuestos útiles para preparar inhibidores del co-transportador 2 sodio glucosa |
Country Status (25)
Country | Link |
---|---|
US (2) | US8026347B2 (es) |
EP (1) | EP2183263B1 (es) |
JP (2) | JP5653213B2 (es) |
KR (1) | KR101663324B1 (es) |
CN (1) | CN101801989B (es) |
AR (2) | AR067701A1 (es) |
AT (1) | ATE530558T1 (es) |
AU (1) | AU2008279424B2 (es) |
BR (1) | BRPI0813840A2 (es) |
CA (1) | CA2694029C (es) |
CL (1) | CL2008002169A1 (es) |
CO (1) | CO6260141A2 (es) |
DK (1) | DK2183263T3 (es) |
EA (1) | EA017411B1 (es) |
EC (1) | ECSP109987A (es) |
ES (1) | ES2375800T3 (es) |
HK (1) | HK1143982A1 (es) |
IL (1) | IL203209A (es) |
NZ (1) | NZ582536A (es) |
PL (1) | PL2183263T3 (es) |
PT (1) | PT2183263E (es) |
TW (2) | TWI506024B (es) |
UA (1) | UA107175C2 (es) |
WO (1) | WO2009014970A1 (es) |
ZA (1) | ZA201000219B (es) |
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TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法 |
BRPI0916769A2 (pt) | 2008-07-15 | 2017-09-26 | Theracos Inc | derivados de benzilbenzeno deuterados e métodos de uso |
TWI472521B (zh) * | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | (2s,3r,4r,5s,6r)-2-(4-氯-3-(4-乙氧苄基)苯基)-6-(甲硫)四氫-2h-哌喃-3,4,5-三醇的固體形態與其使用方法 |
RS52236B (en) | 2008-08-28 | 2012-10-31 | Pfizer Inc. | DIOKASA-BICYCLE DERIVATIVES (3.2.1) OCTOBER-2,3,4-TRIOLA |
ES2527179T3 (es) | 2009-11-02 | 2015-01-21 | Pfizer Inc. | Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol |
RU2564901C2 (ru) | 2009-11-13 | 2015-10-10 | Бристол-Майерс Сквибб Кампани | Композиции метформина с уменьшенной массой |
PL2498759T3 (pl) | 2009-11-13 | 2019-03-29 | Astrazeneca Ab | Formulacje tabletek o natychmiastowym uwalnianiu |
WO2011060256A2 (en) | 2009-11-13 | 2011-05-19 | Bristol-Myers Squibb Company | Bilayer tablet formulations |
TWI562775B (en) * | 2010-03-02 | 2016-12-21 | Lexicon Pharmaceuticals Inc | Methods of using inhibitors of sodium-glucose cotransporters 1 and 2 |
WO2011153712A1 (en) * | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
EP2611442B1 (en) | 2010-09-03 | 2018-07-04 | Bristol-Myers Squibb Company | Drug formulations using water soluble antioxidants |
JP2014504639A (ja) | 2011-02-01 | 2014-02-24 | ブリストル−マイヤーズ スクイブ カンパニー | アミン化合物を含む医薬製剤 |
US9034921B2 (en) | 2011-06-01 | 2015-05-19 | Green Cross Corporation | Diphenylmethane derivatives as SGLT2 inhibitors |
CA2837627A1 (en) | 2011-06-03 | 2012-12-06 | Boehringer Ingelheim International Gmbh | Sglt-2 inhibitors for treating metabolic disorders in patients treated with neuroleptic agents |
US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
US9200025B2 (en) * | 2012-11-20 | 2015-12-01 | Lexicon Pharmaceuticals, Inc. | Inhibitors of sodium glucose cotransporter 1 |
WO2014161836A1 (en) | 2013-04-04 | 2014-10-09 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of metabolic disorders in equine animals |
JP6450769B2 (ja) | 2013-09-27 | 2019-01-09 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | グルコピラノシル誘導体及びその医薬品における使用 |
CN105611920B (zh) | 2013-10-12 | 2021-07-16 | 泰拉科斯萨普有限责任公司 | 羟基-二苯甲烷衍生物的制备 |
EP3862003B1 (en) | 2013-12-17 | 2023-10-25 | Boehringer Ingelheim Vetmedica GmbH | An sglt-2 inhibitor for use in the treatment of a metabolic disorder in feline animals |
PL3096765T3 (pl) | 2014-01-23 | 2019-05-31 | Boehringer Ingelheim Vetmedica Gmbh | Leczenie zaburzeń metabolicznych u zwierząt psowatych |
MX2016012705A (es) | 2014-04-01 | 2016-12-16 | Boehringer Ingelheim Vetmedica Gmbh | Tratamiento de trastornos metabolicos en animales equinos. |
BR112017003570A2 (pt) | 2014-09-25 | 2017-12-05 | Boehringer Ingelheim Vetmedica Gmbh | tratamento de combinação de inibidores de sglt2 e agonistas de dopamina para prevenir distúrbios metabólicos em animais equinos |
EP3466958B1 (en) * | 2016-05-25 | 2020-04-29 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | New crystal forms of sodium-glucose co-transporter inhibitor, processes for preparation and use thereof |
US10793588B2 (en) * | 2016-05-28 | 2020-10-06 | Ji Lin Hui Sheng Bio-Pharmaceutical Co., Ltd. | Crystal form of sodium-glucose cotransporter 2 inhibitor |
KR102233229B1 (ko) | 2016-06-17 | 2021-03-29 | 주식회사 대웅제약 | 다이페닐메탄 유도체의 제조방법 |
EP3528800A1 (en) | 2016-10-19 | 2019-08-28 | Boehringer Ingelheim International GmbH | Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof |
CN107540685B (zh) * | 2017-09-04 | 2020-05-05 | 杭州科巢生物科技有限公司 | 一种Sotagliflozin的制备方法及其中间体 |
JP2021520394A (ja) | 2018-04-17 | 2021-08-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物、処置方法及びその使用 |
CN108675976B (zh) * | 2018-05-14 | 2020-07-14 | 浙江宏元药业股份有限公司 | 一种6-卤代葡萄糖碳苷及其制备方法和应用 |
CA3109107C (en) | 2018-08-13 | 2023-04-25 | Daewoong Pharmaceutical Co., Ltd. | Preparation of intermediate useful for synthesis of a diphenylmethane derivative for use as a sglt inhibitor |
CN110818722B (zh) * | 2018-08-14 | 2022-12-02 | 苏州鹏旭医药科技有限公司 | 三种化合物及其制备方法和在合成索格列净中的用途 |
EP4064854A1 (en) | 2019-11-28 | 2022-10-05 | Boehringer Ingelheim Vetmedica GmbH | Use of sglt-2 inhibitors in the drying-off of non-human mammals |
MX2022010090A (es) | 2020-02-17 | 2022-09-02 | Boehringer Ingelheim Vetmedica Gmbh | Uso de inhibidores de sglt-2 para la prevencion y/o tratamiento de enfermedades cardiacas en felinos. |
EP4376819A1 (en) | 2021-07-28 | 2024-06-05 | Boehringer Ingelheim Vetmedica GmbH | Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals |
US20240307426A1 (en) | 2021-07-28 | 2024-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals |
MX2024001184A (es) | 2021-07-28 | 2024-02-27 | Boehringer Ingelheim Vetmedica Gmbh | Uso de inhibidores de sglt-2 para la prevencion y/o tratamiento de cardiopatias en mamiferos no humanos, que excluye felinos, en particular, caninos. |
CN113880701A (zh) * | 2021-10-10 | 2022-01-04 | 浙江司太立制药股份有限公司 | 一种抗糖尿病药物中间体及其制备方法 |
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WO2024184293A1 (en) | 2023-03-06 | 2024-09-12 | Boehringer Ingelheim Vetmedica Gmbh | Systems for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s) |
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US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
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US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
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US6562791B1 (en) | 2002-03-29 | 2003-05-13 | Council Of Scientific And Industrial Research | Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof |
CA2481572A1 (en) * | 2002-04-12 | 2003-10-23 | Achillion Pharmaceuticals, Inc. | Method for synthesizing .beta.-l-5-fluoro-2',3'-dideoxy-2',3'-didehydrocytidine(.beta.-l-fd4c) |
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CN100391963C (zh) * | 2003-01-03 | 2008-06-04 | 布里斯托尔-迈尔斯斯奎布公司 | 制备c-芳基葡糖苷sglt2抑制剂的方法 |
US7368475B2 (en) * | 2003-03-12 | 2008-05-06 | Kemin Pharma Bvba | Furanose-type bicyclic carbohydrates with biological activity |
TWI309980B (en) | 2003-03-14 | 2009-05-21 | Yamanouchi Pharma Co Ltd | C-glycoside derivatives or salts thereof |
WO2006018150A1 (de) * | 2004-08-11 | 2006-02-23 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
DE602006009772D1 (de) | 2005-02-23 | 2009-11-26 | Boehringer Ingelheim Int | Glucopyranosylsubstituierte ((hetero)arylethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters typ 2 (sglt2) |
TWI499414B (zh) * | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法 |
WO2008044268A1 (fr) * | 2006-10-05 | 2008-04-17 | Panasonic Corporation | Appareil et procédé de transmission |
WO2008109591A1 (en) * | 2007-03-08 | 2008-09-12 | Lexicon Pharmaceuticals, Inc. | Phlorizin analogs as inhibitors of sodium glucose co-transporter 2 |
TWI472521B (zh) | 2008-07-17 | 2015-02-11 | Lexicon Pharmaceuticals Inc | (2s,3r,4r,5s,6r)-2-(4-氯-3-(4-乙氧苄基)苯基)-6-(甲硫)四氫-2h-哌喃-3,4,5-三醇的固體形態與其使用方法 |
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2008
- 2008-07-17 PT PT08826634T patent/PT2183263E/pt unknown
- 2008-07-17 JP JP2010518296A patent/JP5653213B2/ja active Active
- 2008-07-17 US US12/174,722 patent/US8026347B2/en active Active
- 2008-07-17 AU AU2008279424A patent/AU2008279424B2/en active Active
- 2008-07-17 EP EP08826634A patent/EP2183263B1/en active Active
- 2008-07-17 ES ES08826634T patent/ES2375800T3/es active Active
- 2008-07-17 DK DK08826634.1T patent/DK2183263T3/da active
- 2008-07-17 EA EA201070186A patent/EA017411B1/ru not_active IP Right Cessation
- 2008-07-17 BR BRPI0813840A patent/BRPI0813840A2/pt not_active Application Discontinuation
- 2008-07-17 CA CA2694029A patent/CA2694029C/en active Active
- 2008-07-17 AT AT08826634T patent/ATE530558T1/de active
- 2008-07-17 KR KR1020107001659A patent/KR101663324B1/ko active IP Right Grant
- 2008-07-17 PL PL08826634T patent/PL2183263T3/pl unknown
- 2008-07-17 NZ NZ582536A patent/NZ582536A/en unknown
- 2008-07-17 CN CN200880100489.2A patent/CN101801989B/zh active Active
- 2008-07-17 UA UAA201002095A patent/UA107175C2/ru unknown
- 2008-07-17 WO PCT/US2008/070250 patent/WO2009014970A1/en active Application Filing
- 2008-07-21 TW TW102129521A patent/TWI506024B/zh active
- 2008-07-21 TW TW097127665A patent/TWI419886B/zh active
- 2008-07-24 CL CL2008002169A patent/CL2008002169A1/es unknown
- 2008-07-25 AR ARP080103246A patent/AR067701A1/es active IP Right Grant
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2010
- 2010-01-10 IL IL203209A patent/IL203209A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00219A patent/ZA201000219B/en unknown
- 2010-02-23 EC EC2010009987A patent/ECSP109987A/es unknown
- 2010-02-25 CO CO10022864A patent/CO6260141A2/es not_active Application Discontinuation
- 2010-11-12 HK HK10110567.0A patent/HK1143982A1/zh unknown
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2011
- 2011-08-11 US US13/207,576 patent/US8293878B2/en active Active
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2013
- 2013-08-28 JP JP2013176646A patent/JP5764174B2/ja active Active
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2018
- 2018-08-03 AR ARP180102213 patent/AR112669A2/es active IP Right Grant
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