BRPI0813840A2 - métodos e compostos úteis para a preparação de inibidores de cotransportador 2 de glicose de sódio - Google Patents

métodos e compostos úteis para a preparação de inibidores de cotransportador 2 de glicose de sódio

Info

Publication number
BRPI0813840A2
BRPI0813840A2 BRPI0813840A BRPI0813840A BRPI0813840A2 BR PI0813840 A2 BRPI0813840 A2 BR PI0813840A2 BR PI0813840 A BRPI0813840 A BR PI0813840A BR PI0813840 A BRPI0813840 A BR PI0813840A BR PI0813840 A2 BRPI0813840 A2 BR PI0813840A2
Authority
BR
Brazil
Prior art keywords
transporter
inhibitors
preparation
methods
compounds useful
Prior art date
Application number
BRPI0813840A
Other languages
English (en)
Inventor
alden harrison Bryce
Zhang Haiming
Yan Jie
Mangzhu Zhao Matthew
Cathleen Goodwin Nicole
Song Qiuling
Mabon Ross
Iimura Shinya
Wu Wenxue
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of BRPI0813840A2 publication Critical patent/BRPI0813840A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
BRPI0813840A 2007-07-26 2008-07-17 métodos e compostos úteis para a preparação de inibidores de cotransportador 2 de glicose de sódio BRPI0813840A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95212207P 2007-07-26 2007-07-26
PCT/US2008/070250 WO2009014970A1 (en) 2007-07-26 2008-07-17 Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0813840A2 true BRPI0813840A2 (pt) 2017-06-06

Family

ID=39877996

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813840A BRPI0813840A2 (pt) 2007-07-26 2008-07-17 métodos e compostos úteis para a preparação de inibidores de cotransportador 2 de glicose de sódio

Country Status (25)

Country Link
US (2) US8026347B2 (pt)
EP (1) EP2183263B1 (pt)
JP (2) JP5653213B2 (pt)
KR (1) KR101663324B1 (pt)
CN (1) CN101801989B (pt)
AR (2) AR067701A1 (pt)
AT (1) ATE530558T1 (pt)
AU (1) AU2008279424B2 (pt)
BR (1) BRPI0813840A2 (pt)
CA (1) CA2694029C (pt)
CL (1) CL2008002169A1 (pt)
CO (1) CO6260141A2 (pt)
DK (1) DK2183263T3 (pt)
EA (1) EA017411B1 (pt)
EC (1) ECSP109987A (pt)
ES (1) ES2375800T3 (pt)
HK (1) HK1143982A1 (pt)
IL (1) IL203209A (pt)
NZ (1) NZ582536A (pt)
PL (1) PL2183263T3 (pt)
PT (1) PT2183263E (pt)
TW (2) TWI419886B (pt)
UA (1) UA107175C2 (pt)
WO (1) WO2009014970A1 (pt)
ZA (1) ZA201000219B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499414B (zh) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
BRPI0916769A2 (pt) 2008-07-15 2017-09-26 Theracos Inc derivados de benzilbenzeno deuterados e métodos de uso
TWI472521B (zh) * 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法
DK2334687T5 (da) 2008-08-28 2012-09-10 Pfizer Dioxa-bicyclo[3.2.1.]octan-2,3,4-triol-derivater
ES2527179T3 (es) 2009-11-02 2015-01-21 Pfizer Inc. Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol
EP2498757A1 (en) 2009-11-13 2012-09-19 Bristol-Myers Squibb Company Reduced mass metformin formulations
DK2498758T3 (en) 2009-11-13 2018-10-15 Astrazeneca Ab TWO-LAYER TABLET FORMULATIONS
DK2498759T3 (en) 2009-11-13 2018-11-26 Astrazeneca Ab TABLE FORMULATIONS WITH IMMEDIATE RELEASE
TWI562775B (en) * 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
WO2011153712A1 (en) * 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
KR20130137624A (ko) 2010-09-03 2013-12-17 브리스톨-마이어스 스큅 컴퍼니 수용성 항산화제를 사용한 약물 제제
RU2607480C2 (ru) 2011-02-01 2017-01-10 Бристол-Майерс Сквибб Компани Фармацевтические композиции, содержащие аминосоединение
US9034921B2 (en) 2011-06-01 2015-05-19 Green Cross Corporation Diphenylmethane derivatives as SGLT2 inhibitors
JP5835598B2 (ja) 2011-06-03 2015-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 神経弛緩剤で治療されている患者において代謝性障害を治療するためのｓｇｌｔ−２阻害剤
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
ES2728246T3 (es) * 2012-11-20 2019-10-23 Lexicon Pharmaceuticals Inc Inhibidores del cotransportador 1 de sodio-glucosa
HUE064190T2 (hu) 2013-04-04 2024-03-28 Boehringer Ingelheim Vetmedica Gmbh Lófélék anyagcserezavarainak kezelése
ES2605886T3 (es) 2013-09-27 2017-03-16 Sunshine Lake Pharma Co., Ltd. Derivados de glucopiranosilo y sus usos en medicina
WO2015051484A1 (en) 2013-10-12 2015-04-16 Theracos, Inc. Preparation of hydroxy-benzylbenzene derivatives
HRP20231694T1 (hr) 2013-12-17 2024-03-15 Boehringer Ingelheim Vetmedica Gmbh Sglt-2 inhibitor za uporabu u liječenju metaboličkog poremećaja kod životinja iz porodice mačaka
AU2015208291B2 (en) 2014-01-23 2019-12-05 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in canine animals
NZ723781A (en) 2014-04-01 2022-09-30 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in equine animals
JP6727419B2 (ja) * 2016-05-25 2020-07-22 クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド ナトリウム−グルコース共輸送体阻害薬の新規な結晶形及びその製造方法並びに用途
KR102226465B1 (ko) * 2016-05-28 2021-03-11 하이난 수안주 파마 코포레이션 리미티드 나트륨-글루코스 공수송체 2에 대한 억제제의 결정형
ES2898336T3 (es) 2016-06-17 2022-03-07 Dae Woong Pharma Derivado de difenilmetano en forma cristalina
CA3041169A1 (en) 2016-10-19 2018-04-26 Boehringer Ingelheim International Gmbh Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof
CN107540685B (zh) * 2017-09-04 2020-05-05 杭州科巢生物科技有限公司 一种Sotagliflozin的制备方法及其中间体
CN111989103A (zh) 2018-04-17 2020-11-24 勃林格殷格翰国际有限公司 药物组合物、其治疗方法和用途
CN108675976B (zh) * 2018-05-14 2020-07-14 浙江宏元药业股份有限公司 一种6-卤代葡萄糖碳苷及其制备方法和应用
US11661406B2 (en) 2018-08-13 2023-05-30 Daewoong Pharmaceutical Co., Ltd. Method for producing intermediate useful for synthesis of SGLT inhibitor
CN110818722B (zh) * 2018-08-14 2022-12-02 苏州鹏旭医药科技有限公司 三种化合物及其制备方法和在合成索格列净中的用途
CA3158368A1 (en) 2019-11-28 2021-06-03 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors in the drying-off of non-human mammals
CA3167531A1 (en) 2020-02-17 2021-08-26 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines
KR20240040106A (ko) 2021-07-28 2024-03-27 베링거잉겔하임베트메디카게엠베하 비-사람 포유류에서 신장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도
WO2023006745A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
WO2023006718A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in non-human mammals excluding felines, in particular canines
CN113880701A (zh) * 2021-10-10 2022-01-04 浙江司太立制药股份有限公司 一种抗糖尿病药物中间体及其制备方法
US20230381101A1 (en) 2022-05-25 2023-11-30 Boehringer Ingelheim Vetmedica Gmbh Aqueous pharmaceutical compositions comprising sglt-2 inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
HUP0300057A3 (en) * 2000-03-17 2003-09-29 Kissei Pharmaceutical Glucopyranosyloxy benzylbenzene derivatives, pharmaceutical compositions containing the same and intermediates for the preparation of the derivatives
US6683056B2 (en) * 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) * 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US7053060B2 (en) * 2000-11-30 2006-05-30 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
US6936590B2 (en) * 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
WO2002083066A2 (en) * 2001-04-11 2002-10-24 Bristol-Myers Squibb Company Amino acid complexes of c-aryl glucosides for treatment of diabetes and method
US6562791B1 (en) * 2002-03-29 2003-05-13 Council Of Scientific And Industrial Research Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof
RU2310661C2 (ru) * 2002-04-12 2007-11-20 Акиллион Фармасьютикалз, Инк. Способ синтеза бета-l-5-фтор-2', 3'-дидезокси-2', 3'-дидегидроцитидина (бета-l-fd4c)
AU2003254904A1 (en) * 2002-08-09 2004-02-25 Taisho Pharmaceutical Co., Ltd. Aryl 5-thio-beta-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
JP2006516257A (ja) 2003-01-03 2006-06-29 ブリストル−マイヤーズ　スクイブ　カンパニー Ｃ−アリールグルコシドｓｇｌｔ２阻害剤の製造法
US7368475B2 (en) * 2003-03-12 2008-05-06 Kemin Pharma Bvba Furanose-type bicyclic carbohydrates with biological activity
PT1980560E (pt) * 2003-03-14 2011-06-29 Astellas Pharma Inc Derivados de c-glicósido para o tratamento da diabetes
WO2006018150A1 (de) * 2004-08-11 2006-02-23 Boehringer Ingelheim International Gmbh D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
EP1856082B1 (en) * 2005-02-23 2009-10-14 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors
TWI499414B (zh) * 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法
WO2008044268A1 (fr) * 2006-10-05 2008-04-17 Panasonic Corporation Appareil et procédé de transmission
WO2008109591A1 (en) * 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
TWI472521B (zh) * 2008-07-17 2015-02-11 Lexicon Pharmaceuticals Inc （２ｓ，３ｒ，４ｒ，５ｓ，６ｒ）－２－（４－氯－３－（４－乙氧苄基）苯基）－６－（甲硫）四氫－２ｈ－哌喃－３，４，５－三醇的固體形態與其使用方法

Also Published As

Publication number Publication date
TW201350473A (zh) 2013-12-16
EP2183263A1 (en) 2010-05-12
JP5653213B2 (ja) 2015-01-14
AR112669A2 (es) 2019-11-27
ATE530558T1 (de) 2011-11-15
CN101801989B (zh) 2015-11-25
AU2008279424B2 (en) 2013-06-13
AU2008279424A1 (en) 2009-01-29
UA107175C2 (uk) 2014-12-10
US8026347B2 (en) 2011-09-27
US20090030198A1 (en) 2009-01-29
KR20100040869A (ko) 2010-04-21
ES2375800T3 (es) 2012-03-06
US8293878B2 (en) 2012-10-23
AR067701A1 (es) 2009-10-21
KR101663324B1 (ko) 2016-10-06
HK1143982A1 (zh) 2011-01-21
EP2183263B1 (en) 2011-10-26
JP2010534661A (ja) 2010-11-11
CN101801989A (zh) 2010-08-11
TWI506024B (zh) 2015-11-01
ECSP109987A (es) 2010-03-31
CL2008002169A1 (es) 2009-03-20
CA2694029A1 (en) 2009-01-29
US20120095197A1 (en) 2012-04-19
JP2014001230A (ja) 2014-01-09
TWI419886B (zh) 2013-12-21
NZ582536A (en) 2012-01-12
EA017411B1 (ru) 2012-12-28
IL203209A (en) 2014-02-27
PT2183263E (pt) 2012-01-11
CO6260141A2 (es) 2011-03-22
CA2694029C (en) 2016-10-04
DK2183263T3 (da) 2012-01-30
PL2183263T3 (pl) 2012-03-30
TW200914434A (en) 2009-04-01
WO2009014970A1 (en) 2009-01-29
EA201070186A1 (ru) 2010-08-30
ZA201000219B (en) 2011-03-30
JP5764174B2 (ja) 2015-08-12

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]