CU24087B1 - Compuestos de carbazol - Google Patents

Compuestos de carbazol

Info

Publication number
CU24087B1
CU24087B1 CU2011000078A CU20110078A CU24087B1 CU 24087 B1 CU24087 B1 CU 24087B1 CU 2011000078 A CU2011000078 A CU 2011000078A CU 20110078 A CU20110078 A CU 20110078A CU 24087 B1 CU24087 B1 CU 24087B1
Authority
CU
Cuba
Prior art keywords
compounds
diseases
carbazol
conditions
carbazol compounds
Prior art date
Application number
CU2011000078A
Other languages
English (en)
Other versions
CU20110078A7 (es
Inventor
John Tucker
Sergey Sviridov
Leonid Brodsky
Catherine Burkhart
Andrei Purmal
Katerina Gurova
Andrei Gudkov
Original Assignee
Incuron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incuron filed Critical Incuron
Publication of CU20110078A7 publication Critical patent/CU20110078A7/es
Publication of CU24087B1 publication Critical patent/CU24087B1/es

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    • A47C4/02—Dismountable chairs
    • A47C4/028—Upholstered chairs, e.g. metal, plastic or wooden chairs
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B1/00—Devices for securing together, or preventing relative movement between, constructional elements or machine parts
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    • Y10T403/7176—Resilient clip

Abstract

Se exponen compuestos de la fórmula estructural general (I) y (II) ESPACIO PARA LAS FÓRMULAS como agentes terapéuticos. Las enfermedades y condiciones tratables incluyen cánceres, enfermedades y condiciones inflamatorias y enfermedades de inmunodeficiencia.
CU2011000078A 2008-10-06 2009-10-05 Compuestos de carbazol CU24087B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10291308P 2008-10-06 2008-10-06
PCT/US2009/059558 WO2010042445A1 (en) 2008-10-06 2009-10-05 Carbazole compounds and therapeutic uses of the compounds

Publications (2)

Publication Number Publication Date
CU20110078A7 CU20110078A7 (es) 2012-01-31
CU24087B1 true CU24087B1 (es) 2015-03-30

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CU2011000078A CU24087B1 (es) 2008-10-06 2009-10-05 Compuestos de carbazol

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JP (1) JP5694172B2 (es)
KR (1) KR101586112B1 (es)
CN (1) CN102203063B (es)
AP (1) AP2860A (es)
AU (1) AU2009302546B2 (es)
BR (1) BRPI0920876A2 (es)
CA (1) CA2736097C (es)
CU (1) CU24087B1 (es)
CY (1) CY1113924T1 (es)
DK (1) DK2356093T3 (es)
ES (1) ES2402395T3 (es)
GE (1) GEP20146131B (es)
HR (1) HRP20130313T1 (es)
IL (1) IL211430A0 (es)
MX (1) MX2011003416A (es)
NZ (1) NZ591516A (es)
PL (1) PL2356093T3 (es)
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RS (1) RS52702B (es)
RU (1) RU2497807C2 (es)
SI (1) SI2356093T1 (es)
SM (1) SMT201300042B (es)
UA (1) UA107652C2 (es)
WO (1) WO2010042445A1 (es)
ZA (1) ZA201101513B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA107652C2 (en) * 2008-10-06 2015-02-10 Incuron Llc Carbazole compounds and therapeutic uses of the compounds
JP5831068B2 (ja) * 2011-09-13 2015-12-09 コニカミノルタ株式会社 縮合複素環化合物の製造方法
AU2012338362B2 (en) * 2011-11-15 2017-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Tricyclic compounds, compositions comprising them and uses thereof
WO2013148864A1 (en) 2012-03-27 2013-10-03 Andrei Gudkov Curaxins for use in treating breast cancer and method for identifying patients likely to respond
EP2841418B1 (en) 2012-04-25 2017-03-08 F. Hoffmann-La Roche AG (3,4-dichloro-phenyl)-((s)-3-propyl-pyrrolidin-3-yl)-methanone hydrochloride and manufacturing processes
JP6377054B2 (ja) 2012-05-11 2018-08-22 リセット セラピューティークス， インコーポレイテッド クリプトクロム調節薬としてのカルバゾール含有スルホンアミド
US10386370B2 (en) 2013-02-11 2019-08-20 Incuron, Inc. Use of facilitates chromatin transcription complex (FACT) in cancer
PT3013833T (pt) 2013-06-26 2019-03-20 Univ Do Porto Oxazoloisoindolinonas derivadas de triptofanol: ativadoras de molécula pequena da p53
WO2015020553A1 (en) * 2013-08-07 2015-02-12 Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" Carbazole compounds and methods of using same
WO2015020556A1 (ru) * 2013-08-08 2015-02-12 Общество С Ограниченной Ответственностью "Панацела Лабс" Соединения ксеномицина с противогрибковыми свойствами
WO2015050471A1 (en) * 2013-10-02 2015-04-09 Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" Carbazole compounds and methods of using same
WO2015050472A1 (en) * 2013-10-02 2015-04-09 Obschestvo S Ogranichennoy Otvetstvennost'yu "Panacela Labs" Fused indole compounds and methods of using same
RU2016125005A (ru) * 2013-12-10 2018-01-23 ИНКУРОН, ЭлЭлСи Способы модулирования различных биомаркеров при помощи кураксинов
EA033925B1 (ru) * 2014-04-06 2019-12-10 Общество С Ограниченной Ответственностью "Инкурон" Комбинированная терапия гепатоцеллюлярной карциномы
TWI690521B (zh) * 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
CN103936654B (zh) * 2014-04-08 2016-05-18 南京林业大学 一类脱氢枞酸吲哚衍生物的用途
ES2716956T3 (es) * 2014-07-04 2019-06-18 Merck Patent Gmbh Derivados azepanilo y composiciones farmacéuticas que los comprenden con actividad antiparasitaria
CN105272903B (zh) * 2015-11-17 2018-07-10 江苏师范大学 系列含氟咔唑类化合物及其制备方法和应用
CN109593057B (zh) * 2017-09-30 2022-03-04 成都中创蜀洋生物科技有限公司 氘代咔唑类化合物
CN109528712B (zh) * 2019-01-24 2020-11-17 江南大学 9-甲基-3,6-二乙酰基咔唑用于治疗或预防肿瘤疾病的用途
AU2020347539A1 (en) * 2019-09-15 2022-03-31 Raziel Therapeutics Ltd. Compositions for the treatment of solid tumors
WO2023220558A1 (en) * 2022-05-09 2023-11-16 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Combination of curaxins and immune checkpoint inhibitors for treating cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2715680A1 (de) * 1977-04-07 1978-10-12 Henkel Kgaa Haarfaerbemittel
WO2004035580A1 (en) * 2002-10-21 2004-04-29 Aprea Ab Reactivation of wild type p53 in human tumour cells by a low molecular weight compound
EP1462105A1 (en) * 2003-03-28 2004-09-29 Procorde GmbH Activation specific inhibitors of NF-kB and method of treating inflammatory processes in cardio-vascular diseases
US7169802B2 (en) * 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
EP1771203A4 (en) * 2004-07-20 2010-06-02 Cleveland Clinic Foundation INHIBITION OF NF-KB
JP2009001495A (ja) * 2005-10-13 2009-01-08 Taisho Pharmaceutical Co Ltd ２−アリール−ベンゾイミダゾール−５−カルボキサミド誘導体
ES2390135T3 (es) * 2005-11-22 2012-11-06 Merck Sharp & Dohme Corp. Compuestos tricíclicos útiles como inhibidores de quinasas
WO2008008155A2 (en) * 2006-06-20 2008-01-17 The Trustees Of The University Of Pennsylvania Small molecule modulators of p53 family signaling
RU2315594C1 (ru) * 2006-09-01 2008-01-27 Всеволод Иванович Киселев Антиэстрогенное и антипролиферативное средство для лечения и профилактики заболеваний женской репродуктивной системы
UA107652C2 (en) * 2008-10-06 2015-02-10 Incuron Llc Carbazole compounds and therapeutic uses of the compounds
WO2013148864A1 (en) * 2012-03-27 2013-10-03 Andrei Gudkov Curaxins for use in treating breast cancer and method for identifying patients likely to respond

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