ECSP11010974A - Compuestos novedosos como ligandos receptores de canabinoides - Google Patents
Compuestos novedosos como ligandos receptores de canabinoidesInfo
- Publication number
- ECSP11010974A ECSP11010974A EC2011010974A ECSP11010974A ECSP11010974A EC SP11010974 A ECSP11010974 A EC SP11010974A EC 2011010974 A EC2011010974 A EC 2011010974A EC SP11010974 A ECSP11010974 A EC SP11010974A EC SP11010974 A ECSP11010974 A EC SP11010974A
- Authority
- EC
- Ecuador
- Prior art keywords
- canabinoid
- new compounds
- receiving links
- compounds
- links
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Ligandos de receptores de canabinoides de la fórmula (I) (consta diseño) en donde A1, A5, Rx, X4 y z son como se definen en la memoria descriptiva. Se divulgan asimismo composiciones que comprenden dichos compuestos y métodos para el tratamiento de condiciones y trastornos usando dichos compuestos y composiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9737808P | 2008-09-16 | 2008-09-16 | |
US22420009P | 2009-07-09 | 2009-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP11010974A true ECSP11010974A (es) | 2011-05-31 |
Family
ID=41210849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2011010974A ECSP11010974A (es) | 2008-09-16 | 2011-04-12 | Compuestos novedosos como ligandos receptores de canabinoides |
Country Status (23)
Country | Link |
---|---|
US (2) | US8188135B2 (es) |
EP (3) | EP2896615A1 (es) |
JP (1) | JP2012502917A (es) |
KR (1) | KR20110061619A (es) |
CN (1) | CN102216277A (es) |
AR (2) | AR073599A1 (es) |
AU (1) | AU2009293319A1 (es) |
BR (1) | BRPI0919135A2 (es) |
CA (1) | CA2737199A1 (es) |
CL (1) | CL2011000544A1 (es) |
CO (1) | CO6361998A2 (es) |
DO (1) | DOP2011000081A (es) |
EC (1) | ECSP11010974A (es) |
ES (1) | ES2556752T3 (es) |
IL (1) | IL211406A0 (es) |
MX (1) | MX2011002811A (es) |
PA (1) | PA8842501A1 (es) |
PE (1) | PE20110804A1 (es) |
RU (1) | RU2011115087A (es) |
TW (1) | TW201016692A (es) |
UY (1) | UY32125A (es) |
WO (1) | WO2010033543A2 (es) |
ZA (1) | ZA201101590B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
WO2007140385A2 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Thiazole compounds as cannabinoid receptor ligands and uses thereof |
CA2647598A1 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
CN101765594A (zh) | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物 |
US7872033B2 (en) * | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
WO2008144360A1 (en) * | 2007-05-18 | 2008-11-27 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
US9193713B2 (en) * | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
MX2010010023A (es) | 2008-03-11 | 2010-11-30 | Abbott Lab | Compuestos novedosos como ligandos receptores de canabinoides. |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CN102216277A (zh) * | 2008-09-16 | 2011-10-12 | 雅培制药有限公司 | 作为大麻素受体配体的被取代的苯甲酰胺 |
PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
ES2542234T3 (es) * | 2009-03-27 | 2015-08-03 | Abbvie Inc. | Compuestos como ligandos de receptores cannabinoides |
WO2011159785A1 (en) | 2010-06-15 | 2011-12-22 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
ES2637029T3 (es) * | 2014-05-19 | 2017-10-10 | Syngenta Participations Ag | Derivados amídicos activos como insecticidas con grupos piridino o fenilo sustituidos con azufre |
EP3212241B1 (en) * | 2014-10-27 | 2019-05-08 | F. Hoffmann-La Roche AG | Radiolabeled cannabinoid receptor 2 ligand |
CN106749078B (zh) * | 2015-11-23 | 2019-01-04 | 中国科学院大连化学物理研究所 | 一种2-亚胺基恶唑的合成方法 |
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-
2009
- 2009-09-16 CN CN2009801455637A patent/CN102216277A/zh active Pending
- 2009-09-16 EP EP15151451.0A patent/EP2896615A1/en not_active Withdrawn
- 2009-09-16 WO PCT/US2009/057088 patent/WO2010033543A2/en active Application Filing
- 2009-09-16 TW TW098131294A patent/TW201016692A/zh unknown
- 2009-09-16 AU AU2009293319A patent/AU2009293319A1/en not_active Abandoned
- 2009-09-16 PE PE2011000626A patent/PE20110804A1/es not_active Application Discontinuation
- 2009-09-16 KR KR1020117008389A patent/KR20110061619A/ko not_active Application Discontinuation
- 2009-09-16 UY UY0001032125A patent/UY32125A/es not_active Application Discontinuation
- 2009-09-16 US US12/560,897 patent/US8188135B2/en active Active
- 2009-09-16 PA PA20098842501A patent/PA8842501A1/es unknown
- 2009-09-16 BR BRPI0919135A patent/BRPI0919135A2/pt not_active IP Right Cessation
- 2009-09-16 JP JP2011527056A patent/JP2012502917A/ja active Pending
- 2009-09-16 AR ARP090103558A patent/AR073599A1/es not_active Application Discontinuation
- 2009-09-16 EP EP11192134.2A patent/EP2428507B1/en active Active
- 2009-09-16 RU RU2011115087/04A patent/RU2011115087A/ru not_active Application Discontinuation
- 2009-09-16 EP EP09792591A patent/EP2334646A2/en not_active Withdrawn
- 2009-09-16 US US12/560,893 patent/US8859596B2/en not_active Expired - Fee Related
- 2009-09-16 ES ES11192134.2T patent/ES2556752T3/es active Active
- 2009-09-16 MX MX2011002811A patent/MX2011002811A/es not_active Application Discontinuation
- 2009-09-16 CA CA2737199A patent/CA2737199A1/en not_active Abandoned
-
2010
- 2010-07-14 AR ARP100102555A patent/AR077664A2/es not_active Application Discontinuation
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2011
- 2011-02-24 IL IL211406A patent/IL211406A0/en unknown
- 2011-03-01 ZA ZA2011/01590A patent/ZA201101590B/en unknown
- 2011-03-15 DO DO2011000081A patent/DOP2011000081A/es unknown
- 2011-03-15 CL CL2011000544A patent/CL2011000544A1/es unknown
- 2011-03-23 CO CO11035303A patent/CO6361998A2/es not_active Application Discontinuation
- 2011-04-12 EC EC2011010974A patent/ECSP11010974A/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW201016692A (en) | 2010-05-01 |
CN102216277A (zh) | 2011-10-12 |
EP2428507A2 (en) | 2012-03-14 |
WO2010033543A2 (en) | 2010-03-25 |
JP2012502917A (ja) | 2012-02-02 |
BRPI0919135A2 (pt) | 2015-12-08 |
PE20110804A1 (es) | 2011-11-30 |
EP2896615A1 (en) | 2015-07-22 |
CO6361998A2 (es) | 2012-01-20 |
EP2428507A3 (en) | 2012-06-13 |
UY32125A (es) | 2010-04-30 |
AR077664A2 (es) | 2011-09-14 |
CA2737199A1 (en) | 2010-03-25 |
CL2011000544A1 (es) | 2011-06-17 |
IL211406A0 (en) | 2011-05-31 |
RU2011115087A (ru) | 2012-10-27 |
AR073599A1 (es) | 2010-11-17 |
ZA201101590B (en) | 2012-08-29 |
US8188135B2 (en) | 2012-05-29 |
US8859596B2 (en) | 2014-10-14 |
KR20110061619A (ko) | 2011-06-09 |
ES2556752T3 (es) | 2016-01-20 |
MX2011002811A (es) | 2011-04-12 |
DOP2011000081A (es) | 2011-07-15 |
US20100069349A1 (en) | 2010-03-18 |
EP2428507B1 (en) | 2015-10-21 |
US20100069348A1 (en) | 2010-03-18 |
PA8842501A1 (es) | 2010-04-21 |
WO2010033543A3 (en) | 2010-11-18 |
AU2009293319A1 (en) | 2010-03-25 |
EP2334646A2 (en) | 2011-06-22 |
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