PA8842501A1 - Compuestos novedosos como ligandos de receptores de canabinoides - Google Patents
Compuestos novedosos como ligandos de receptores de canabinoidesInfo
- Publication number
- PA8842501A1 PA8842501A1 PA20098842501A PA8842501A PA8842501A1 PA 8842501 A1 PA8842501 A1 PA 8842501A1 PA 20098842501 A PA20098842501 A PA 20098842501A PA 8842501 A PA8842501 A PA 8842501A PA 8842501 A1 PA8842501 A1 PA 8842501A1
- Authority
- PA
- Panama
- Prior art keywords
- canabinoid
- ligands
- receivers
- new compounds
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
LIGANDOS DE RECEPTORES DE CANABINOIDES DE LA FÓRMULA (I) EN DONDE A1, A5, RX, X4 Y Z SON COMO SE DEFINEN EN LA MEMORIA DESCRIPTIVA. SE DIVULGAN ASIMISMO COMPOSICIONES QUE COMPRENDEN DICHOS COMPUESTOS Y MÉTODOS PARA EL TRATAMIENTO DE CONDICIONES Y TRASTORNOS USANDO DICHOS COMPUESTOS Y COMPOSICIONES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9737808P | 2008-09-16 | 2008-09-16 | |
US22420009P | 2009-07-09 | 2009-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8842501A1 true PA8842501A1 (es) | 2010-04-21 |
Family
ID=41210849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20098842501A PA8842501A1 (es) | 2008-09-16 | 2009-09-16 | Compuestos novedosos como ligandos de receptores de canabinoides |
Country Status (23)
Country | Link |
---|---|
US (2) | US8188135B2 (es) |
EP (3) | EP2334646A2 (es) |
JP (1) | JP2012502917A (es) |
KR (1) | KR20110061619A (es) |
CN (1) | CN102216277A (es) |
AR (2) | AR073599A1 (es) |
AU (1) | AU2009293319A1 (es) |
BR (1) | BRPI0919135A2 (es) |
CA (1) | CA2737199A1 (es) |
CL (1) | CL2011000544A1 (es) |
CO (1) | CO6361998A2 (es) |
DO (1) | DOP2011000081A (es) |
EC (1) | ECSP11010974A (es) |
ES (1) | ES2556752T3 (es) |
IL (1) | IL211406A0 (es) |
MX (1) | MX2011002811A (es) |
PA (1) | PA8842501A1 (es) |
PE (1) | PE20110804A1 (es) |
RU (1) | RU2011115087A (es) |
TW (1) | TW201016692A (es) |
UY (1) | UY32125A (es) |
WO (1) | WO2010033543A2 (es) |
ZA (1) | ZA201101590B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101454302A (zh) * | 2006-05-31 | 2009-06-10 | 艾博特公司 | 用作大麻素受体配位体的噻唑化合物及其用途 |
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
WO2007140439A2 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Compounds as cannabinoid receptor ligands and uses thereof |
MX2009010363A (es) | 2007-03-28 | 2009-12-04 | Abbott Lab | Compuestos de 1,3-tiazol-2(3h)-ilideno como ligandos del receptor canabinoide. |
US7872033B2 (en) * | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
JP2010527929A (ja) | 2007-05-18 | 2010-08-19 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての新規な化合物 |
US9193713B2 (en) * | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CN102036984A (zh) | 2008-03-11 | 2011-04-27 | 雅培制药有限公司 | 作为大麻素受体配体的新化合物 |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
WO2010033543A2 (en) | 2008-09-16 | 2010-03-25 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
EP2411371B1 (en) | 2009-03-27 | 2015-05-20 | AbbVie Inc. | Compounds as cannabinoid receptor ligands |
US8586596B2 (en) | 2010-06-15 | 2013-11-19 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
BR112016026941A2 (pt) * | 2014-05-19 | 2018-07-10 | Syngenta Participations Ag | derivados de amida ativos do ponto de vista inseticida com grupos fenila ou piridina substituídos com enxofre. |
RU2017116665A (ru) * | 2014-10-27 | 2018-11-29 | Ф. Хоффманн-Ля Рош Аг | Радиоактивномеченый лиганд каннабиноидных рецепторов 2 |
CN106749078B (zh) * | 2015-11-23 | 2019-01-04 | 中国科学院大连化学物理研究所 | 一种2-亚胺基恶唑的合成方法 |
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-
2009
- 2009-09-16 WO PCT/US2009/057088 patent/WO2010033543A2/en active Application Filing
- 2009-09-16 AR ARP090103558A patent/AR073599A1/es not_active Application Discontinuation
- 2009-09-16 MX MX2011002811A patent/MX2011002811A/es not_active Application Discontinuation
- 2009-09-16 KR KR1020117008389A patent/KR20110061619A/ko not_active Application Discontinuation
- 2009-09-16 BR BRPI0919135A patent/BRPI0919135A2/pt not_active IP Right Cessation
- 2009-09-16 PE PE2011000626A patent/PE20110804A1/es not_active Application Discontinuation
- 2009-09-16 EP EP09792591A patent/EP2334646A2/en not_active Withdrawn
- 2009-09-16 JP JP2011527056A patent/JP2012502917A/ja active Pending
- 2009-09-16 AU AU2009293319A patent/AU2009293319A1/en not_active Abandoned
- 2009-09-16 EP EP15151451.0A patent/EP2896615A1/en not_active Withdrawn
- 2009-09-16 CA CA2737199A patent/CA2737199A1/en not_active Abandoned
- 2009-09-16 EP EP11192134.2A patent/EP2428507B1/en active Active
- 2009-09-16 UY UY0001032125A patent/UY32125A/es not_active Application Discontinuation
- 2009-09-16 CN CN2009801455637A patent/CN102216277A/zh active Pending
- 2009-09-16 US US12/560,897 patent/US8188135B2/en not_active Expired - Fee Related
- 2009-09-16 TW TW098131294A patent/TW201016692A/zh unknown
- 2009-09-16 RU RU2011115087/04A patent/RU2011115087A/ru not_active Application Discontinuation
- 2009-09-16 US US12/560,893 patent/US8859596B2/en not_active Expired - Fee Related
- 2009-09-16 ES ES11192134.2T patent/ES2556752T3/es active Active
- 2009-09-16 PA PA20098842501A patent/PA8842501A1/es unknown
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2010
- 2010-07-14 AR ARP100102555A patent/AR077664A2/es not_active Application Discontinuation
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2011
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- 2011-03-01 ZA ZA2011/01590A patent/ZA201101590B/en unknown
- 2011-03-15 CL CL2011000544A patent/CL2011000544A1/es unknown
- 2011-03-15 DO DO2011000081A patent/DOP2011000081A/es unknown
- 2011-03-23 CO CO11035303A patent/CO6361998A2/es not_active Application Discontinuation
- 2011-04-12 EC EC2011010974A patent/ECSP11010974A/es unknown
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UY32125A (es) | 2010-04-30 |
AR073599A1 (es) | 2010-11-17 |
EP2896615A1 (en) | 2015-07-22 |
PE20110804A1 (es) | 2011-11-30 |
AU2009293319A1 (en) | 2010-03-25 |
US8859596B2 (en) | 2014-10-14 |
ES2556752T3 (es) | 2016-01-20 |
EP2334646A2 (en) | 2011-06-22 |
CA2737199A1 (en) | 2010-03-25 |
RU2011115087A (ru) | 2012-10-27 |
ZA201101590B (en) | 2012-08-29 |
EP2428507B1 (en) | 2015-10-21 |
CO6361998A2 (es) | 2012-01-20 |
KR20110061619A (ko) | 2011-06-09 |
BRPI0919135A2 (pt) | 2015-12-08 |
US20100069349A1 (en) | 2010-03-18 |
MX2011002811A (es) | 2011-04-12 |
IL211406A0 (en) | 2011-05-31 |
DOP2011000081A (es) | 2011-07-15 |
WO2010033543A2 (en) | 2010-03-25 |
EP2428507A2 (en) | 2012-03-14 |
WO2010033543A3 (en) | 2010-11-18 |
ECSP11010974A (es) | 2011-05-31 |
US8188135B2 (en) | 2012-05-29 |
CN102216277A (zh) | 2011-10-12 |
AR077664A2 (es) | 2011-09-14 |
JP2012502917A (ja) | 2012-02-02 |
EP2428507A3 (en) | 2012-06-13 |
US20100069348A1 (en) | 2010-03-18 |
TW201016692A (en) | 2010-05-01 |
CL2011000544A1 (es) | 2011-06-17 |
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