DOP2011000081A - Benzamida sustituida como ligandos del receptor de canabinoides - Google Patents
Benzamida sustituida como ligandos del receptor de canabinoidesInfo
- Publication number
- DOP2011000081A DOP2011000081A DO2011000081A DO2011000081A DOP2011000081A DO P2011000081 A DOP2011000081 A DO P2011000081A DO 2011000081 A DO2011000081 A DO 2011000081A DO 2011000081 A DO2011000081 A DO 2011000081A DO P2011000081 A DOP2011000081 A DO P2011000081A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- ligands
- benzamida
- canabinoid
- receiver
- replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Ligandos de receptores de canabinoides de la fórmula (l) en donde A1, A5, Rx, X4 y z son como se definen en la memoria descriptiva. Se divulgan asímismo composiciones que comprenden dichos compuestos y métodos para el tratamiento de condiciones y trastornos usando dichos com puestos y com posiciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9737808P | 2008-09-16 | 2008-09-16 | |
US22420009P | 2009-07-09 | 2009-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2011000081A true DOP2011000081A (es) | 2011-07-15 |
Family
ID=41210849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2011000081A DOP2011000081A (es) | 2008-09-16 | 2011-03-15 | Benzamida sustituida como ligandos del receptor de canabinoides |
Country Status (23)
Country | Link |
---|---|
US (2) | US8859596B2 (es) |
EP (3) | EP2334646A2 (es) |
JP (1) | JP2012502917A (es) |
KR (1) | KR20110061619A (es) |
CN (1) | CN102216277A (es) |
AR (2) | AR073599A1 (es) |
AU (1) | AU2009293319A1 (es) |
BR (1) | BRPI0919135A2 (es) |
CA (1) | CA2737199A1 (es) |
CL (1) | CL2011000544A1 (es) |
CO (1) | CO6361998A2 (es) |
DO (1) | DOP2011000081A (es) |
EC (1) | ECSP11010974A (es) |
ES (1) | ES2556752T3 (es) |
IL (1) | IL211406A0 (es) |
MX (1) | MX2011002811A (es) |
PA (1) | PA8842501A1 (es) |
PE (1) | PE20110804A1 (es) |
RU (1) | RU2011115087A (es) |
TW (1) | TW201016692A (es) |
UY (1) | UY32125A (es) |
WO (1) | WO2010033543A2 (es) |
ZA (1) | ZA201101590B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007266535A1 (en) * | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Thiazole compounds as cannabinoid receptor ligands and uses thereof |
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
CN101448800A (zh) * | 2006-05-31 | 2009-06-03 | 艾博特公司 | 作为大麻素受体配体的新型化合物及其用途 |
CN101765594A (zh) | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物 |
US7872033B2 (en) * | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
CA2683086A1 (en) | 2007-05-18 | 2008-11-18 | Abbott Laboratories | Color tunable light source |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
TW200942535A (en) | 2008-03-11 | 2009-10-16 | Abbott Lab | Novel compounds as cannabinoid receptor ligands |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US8859596B2 (en) | 2008-09-16 | 2014-10-14 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
WO2010111574A1 (en) * | 2009-03-27 | 2010-09-30 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8586596B2 (en) | 2010-06-15 | 2013-11-19 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CN103396376B (zh) * | 2013-07-31 | 2016-08-10 | 杨文茂 | 一种抗菌抗癌活性化合物 |
CN106458909B (zh) * | 2014-05-19 | 2020-03-17 | 先正达参股股份有限公司 | 具有硫取代的苯基或吡啶基团的具杀虫活性的酰胺衍生物 |
CA2956056A1 (en) | 2014-10-27 | 2016-05-06 | F. Hoffmann-La Roche Ag | Radiolabeled cannabinoid receptor 2 ligand |
CN106749078B (zh) * | 2015-11-23 | 2019-01-04 | 中国科学院大连化学物理研究所 | 一种2-亚胺基恶唑的合成方法 |
Family Cites Families (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1522361A1 (de) | 1966-03-08 | 1969-07-24 | Agfa Gevaert Ag | Sensibilisierung lichtempfindlicher Polymerer |
US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
DE1772867A1 (de) | 1968-07-15 | 1971-06-16 | Agfa Gevaert Ag | Sensibilisierung von Schichten aus lichtvernetzbaren Polymeren |
JPS5089367A (es) * | 1973-12-14 | 1975-07-17 | ||
JPS57171986A (en) | 1981-04-14 | 1982-10-22 | Taiho Yakuhin Kogyo Kk | Heterocylic ring compound containing sulfur |
DE3333450A1 (de) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Trihalogenmethylgruppen enthaltende carbonylmethylenheterocyclen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindungen enthaelt |
US4885295A (en) * | 1984-08-06 | 1989-12-05 | Sterling Drug Inc. | Method of use of 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles |
US4978664A (en) * | 1984-08-06 | 1990-12-18 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indole pharmaceutical compositions |
DE3533331A1 (de) | 1985-09-18 | 1987-03-26 | Heumann Ludwig & Co Gmbh | Pyridothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3807381A1 (de) * | 1988-03-07 | 1989-09-21 | Hoechst Ag | 4,6-bis-trichlormethyl-s-triazin-2-ylgruppen enthaltende heterocyclische verbindungen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindung enthaelt |
TW205041B (es) | 1989-08-07 | 1993-05-01 | Fujisawa Pharmaceutical Co | |
DE4021439A1 (de) * | 1989-12-14 | 1991-06-20 | Bayer Ag | 2-iminopyridin-derivate |
US6559186B1 (en) * | 1990-02-26 | 2003-05-06 | Arc 1, Inc. | Compositions and methods of treatment of sympathetically maintained pain |
US4973587A (en) * | 1990-03-08 | 1990-11-27 | Sterling Drug Inc. | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method |
US5013837A (en) * | 1990-03-08 | 1991-05-07 | Sterling Drug Inc. | 3-Arylcarbonyl-1H-indole-containing compounds |
WO1992015564A1 (en) | 1991-03-11 | 1992-09-17 | Nippon Soda Co., Ltd. | Novel heterocyclic compound |
EP0629623B1 (en) * | 1992-03-03 | 1999-05-19 | Idemitsu Kosan Company Limited | Pyrazole derivative |
DE69319956T2 (de) | 1992-04-30 | 1999-01-14 | Hodogaya Chemical Co Ltd | Benzothiazolederivate und diese enthaltende fungizide Zusammensetzungen für Landwirtschaft und Gartenbau |
US5654322A (en) * | 1992-08-11 | 1997-08-05 | Wakunaga Seiyaku Kabushiki Kaisha | Biphenylmethane derivatives and pharmaceuticals containing the same |
JPH07507574A (ja) * | 1993-04-05 | 1995-08-24 | 藤沢薬品工業株式会社 | テストステロン5α−レダクターゼ阻害剤用インドール誘導体 |
US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
JPH06345736A (ja) | 1993-06-14 | 1994-12-20 | Tokuyama Soda Co Ltd | ウレタン化合物を製造する方法 |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
AU2641295A (en) | 1994-05-17 | 1995-12-05 | Dowelanco | N-(5-isothiazolyl)amide pesticides |
CA2194671A1 (en) | 1994-07-08 | 1996-01-25 | Ev3 Inc. | Method of forming medical devices; intravascular occlusion devices |
FR2735774B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
AU6964096A (en) | 1995-09-15 | 1997-04-01 | Pharmacia & Upjohn Company | Aminoaryl oxazolidinone n-oxides |
US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
US6323214B1 (en) * | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
US6358992B1 (en) * | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
PT1171437E (pt) | 1999-04-20 | 2004-03-31 | Syngenta Ltd | Pesticidas derivados de indazole ou benzotriazole |
DE19928033A1 (de) | 1999-06-18 | 2000-12-21 | Basf Ag | Verwendung von cyclischen Enaminen als Lichtschutzmittel |
FR2796643B1 (fr) | 1999-07-22 | 2005-04-29 | Sod Conseils Rech Applic | Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
DK1206474T3 (da) | 1999-08-27 | 2004-10-04 | Abbott Lab | Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer |
WO2001019807A1 (fr) | 1999-09-14 | 2001-03-22 | Shionogi & Co., Ltd. | Derives de 2-imino-1,3-thiazine |
EP1223929B1 (en) | 1999-10-18 | 2006-08-23 | The University Of Connecticut | Cannabimimetic indole derivatives |
GB0002032D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
GB0002034D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
GB0006289D0 (en) * | 2000-03-15 | 2000-05-03 | Smithkline Beecham Plc | New use |
GB0010437D0 (en) | 2000-04-28 | 2000-06-14 | Darwin Discovery Ltd | Process |
ES2336425T3 (es) | 2000-06-30 | 2010-04-13 | Dainippon Sumitomo Pharma Co., Ltd. | Derivados de tiazoles utiles como agentes antiinflamatorios. |
US6369052B1 (en) * | 2000-08-07 | 2002-04-09 | Georgetown University | Combination of huperzine and nicotinic compounds as a neuroprotective agent |
FR2816938B1 (fr) * | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
CA2436133A1 (en) | 2001-01-29 | 2002-08-08 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
AU2002310441A1 (en) | 2001-06-14 | 2003-01-02 | The Regents Of The University Of California | A novel signaling pathway for the production of inflammatory pain and neuropathy |
US7949668B2 (en) * | 2001-08-20 | 2011-05-24 | Pardalis, Inc. | Common point authoring system for the complex sharing of hierarchically authored data objects in a distribution chain |
JPWO2003029199A1 (ja) * | 2001-09-28 | 2005-01-13 | 武田薬品工業株式会社 | ベンゼン誘導体、その製造法および用途 |
ATE375331T1 (de) * | 2001-11-01 | 2007-10-15 | Janssen Pharmaceutica Nv | Amidderivate als inhibitoren der glycogensynthasekinase-3-beta |
US6727247B2 (en) | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
IL165217A0 (en) | 2002-05-16 | 2005-12-18 | Bayer Cropscience Gmbh | Pesticidal pyridinecarboxamide derivatives |
JP3902523B2 (ja) * | 2002-08-05 | 2007-04-11 | 富士フイルム株式会社 | 光情報記録媒体および情報記録方法 |
US20040077617A1 (en) * | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Fused cycloalkyl amides and acids and their therapeutic applications |
FR2847899B1 (fr) | 2002-11-29 | 2006-04-28 | Sanofi Synthelabo | Derives d'indole-3-carboxamide, leur preparation et leur application en therapeutique |
US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
US20040259887A1 (en) | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
JPWO2005000825A1 (ja) | 2003-06-27 | 2006-08-03 | 住友製薬株式会社 | チアゾールイミン類およびオキサゾールイミン類 |
US6964237B2 (en) | 2003-06-30 | 2005-11-15 | Mark P. Hepp | Grate block for a refuse incineration grate |
AU2004270394A1 (en) | 2003-09-10 | 2005-03-17 | Gpc Biotech Ag | Heterobicyclic compounds as pharmaceutically active agents |
KR100773650B1 (ko) | 2003-12-08 | 2007-11-05 | 에프. 호프만-라 로슈 아게 | 신규한 싸이아졸 유도체 |
GB0402357D0 (en) | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
US7307163B2 (en) | 2004-04-19 | 2007-12-11 | Symed Labs Limited | Process for the preparation of linezolid and related compounds |
SE0401342D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds |
SE0401345D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
DE602004020812D1 (de) | 2004-07-20 | 2009-06-04 | Symed Labs Ltd | Neue zwischenprodukte für linezolid und verwandte verbindungen |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
US20080312435A1 (en) | 2004-11-15 | 2008-12-18 | Taisho Pharmaceutical Co., Ltd. | Imine Compound |
CA2592378A1 (en) * | 2004-12-21 | 2006-06-29 | Abbott Laboratories | 3-cycloalkylcarbonyl indoles as cannabinoid receptor ligands |
FR2880023B1 (fr) | 2004-12-23 | 2007-02-23 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique |
US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
TW200700387A (en) | 2005-03-21 | 2007-01-01 | Akzo Nobel Nv | 1-benzylindole-2-carboxamide derivatives |
US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
WO2007046550A1 (en) * | 2005-10-21 | 2007-04-26 | Mitsubishi Tanabe Pharma Corporation | Pyrazole compounds having cannabinoid receptor (cb1) antagonizing activity |
AR057987A1 (es) | 2005-11-24 | 2008-01-09 | Astrazeneca Ab | Compuestos agonistas de cb1 (receptor cannabinoide) |
KR100778673B1 (ko) | 2005-12-26 | 2007-11-22 | 주식회사 포스코 | 용철 제조 장치 |
AU2007266535A1 (en) | 2006-05-31 | 2007-12-06 | Abbott Laboratories | Thiazole compounds as cannabinoid receptor ligands and uses thereof |
US8841334B2 (en) * | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
CN101448800A (zh) | 2006-05-31 | 2009-06-03 | 艾博特公司 | 作为大麻素受体配体的新型化合物及其用途 |
TW200813000A (en) | 2006-06-27 | 2008-03-16 | Abbott Lab | Thiazoline and oxazoline derivatives and their methods of use |
WO2008012105A1 (en) * | 2006-07-28 | 2008-01-31 | Synthon B.V. | Crystalline erlotinib |
WO2008028094A1 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Compounds as cb2 cannabinoid receptor ligands |
WO2008028093A1 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Compounds as cb2 cannabinoid receptor ligands |
US8481574B2 (en) * | 2006-10-12 | 2013-07-09 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
US7793912B2 (en) * | 2006-11-08 | 2010-09-14 | Denso Corporation | Fluid pressure actuated poppet valve |
US9763894B2 (en) * | 2006-12-05 | 2017-09-19 | Virginia Commonwealth University | Inflammation therapy |
TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
WO2008079687A1 (en) * | 2006-12-22 | 2008-07-03 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands and uses thereof |
WO2008098857A1 (en) | 2007-02-15 | 2008-08-21 | F. Hoffmann-La Roche Ag | 2-aminooxazolines as taar1 ligands |
CN101765594A (zh) * | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物 |
US7872033B2 (en) * | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8501794B2 (en) * | 2007-04-17 | 2013-08-06 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
EP2148867B1 (en) * | 2007-04-19 | 2014-09-10 | Concert Pharmaceuticals Inc. | Deuterated morpholinyl compounds |
CA2683086A1 (en) | 2007-05-18 | 2008-11-18 | Abbott Laboratories | Color tunable light source |
US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
US8338623B2 (en) | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US20090131485A1 (en) * | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
US20090088416A1 (en) * | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
US20090082471A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
JP2010540635A (ja) | 2007-10-02 | 2010-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | ピリミジンジオン誘導体 |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
WO2009051782A1 (en) | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
US8044071B2 (en) * | 2007-10-18 | 2011-10-25 | Abbott Laboratories | Method for reducing side effects of CB2 receptor agonist therapy using a combination of a selective CB2 receptor agonist and a selective CB1 receptor antagonist |
CA2703591C (en) * | 2007-10-26 | 2013-05-07 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
CA2706586A1 (en) | 2007-11-21 | 2009-05-28 | Alan S. Florjancic | Novel compounds as cannabinoid receptor ligands and uses thereof |
TW200942535A (en) * | 2008-03-11 | 2009-10-16 | Abbott Lab | Novel compounds as cannabinoid receptor ligands |
CA2731102A1 (en) * | 2008-08-15 | 2010-02-18 | Abbott Laboratories | Imine derivatives as cannabinoid receptor ligands |
US8846730B2 (en) * | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
US8859596B2 (en) | 2008-09-16 | 2014-10-14 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
MX2011004749A (es) | 2008-11-04 | 2011-06-01 | Abbott Lab | Nuevos compuestos como ligandos del receptor de canabinoide. |
PA8854001A1 (es) * | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
ES2540119T3 (es) | 2009-03-27 | 2015-07-08 | Abbvie Inc. | Compuestos como ligandos de receptores cannabinoides |
MX2011010157A (es) * | 2009-03-27 | 2011-10-11 | Abbott Lab | Compuestos utiles como ligandos del receptor canabinoide. |
WO2010111574A1 (en) | 2009-03-27 | 2010-09-30 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
US8586596B2 (en) * | 2010-06-15 | 2013-11-19 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
-
2009
- 2009-09-16 US US12/560,893 patent/US8859596B2/en not_active Expired - Fee Related
- 2009-09-16 EP EP09792591A patent/EP2334646A2/en not_active Withdrawn
- 2009-09-16 US US12/560,897 patent/US8188135B2/en active Active
- 2009-09-16 JP JP2011527056A patent/JP2012502917A/ja active Pending
- 2009-09-16 TW TW098131294A patent/TW201016692A/zh unknown
- 2009-09-16 KR KR1020117008389A patent/KR20110061619A/ko not_active Application Discontinuation
- 2009-09-16 ES ES11192134.2T patent/ES2556752T3/es active Active
- 2009-09-16 WO PCT/US2009/057088 patent/WO2010033543A2/en active Application Filing
- 2009-09-16 UY UY0001032125A patent/UY32125A/es not_active Application Discontinuation
- 2009-09-16 MX MX2011002811A patent/MX2011002811A/es not_active Application Discontinuation
- 2009-09-16 CN CN2009801455637A patent/CN102216277A/zh active Pending
- 2009-09-16 EP EP15151451.0A patent/EP2896615A1/en not_active Withdrawn
- 2009-09-16 RU RU2011115087/04A patent/RU2011115087A/ru not_active Application Discontinuation
- 2009-09-16 EP EP11192134.2A patent/EP2428507B1/en active Active
- 2009-09-16 CA CA2737199A patent/CA2737199A1/en not_active Abandoned
- 2009-09-16 PA PA20098842501A patent/PA8842501A1/es unknown
- 2009-09-16 AU AU2009293319A patent/AU2009293319A1/en not_active Abandoned
- 2009-09-16 AR ARP090103558A patent/AR073599A1/es not_active Application Discontinuation
- 2009-09-16 PE PE2011000626A patent/PE20110804A1/es not_active Application Discontinuation
- 2009-09-16 BR BRPI0919135A patent/BRPI0919135A2/pt not_active IP Right Cessation
-
2010
- 2010-07-14 AR ARP100102555A patent/AR077664A2/es not_active Application Discontinuation
-
2011
- 2011-02-24 IL IL211406A patent/IL211406A0/en unknown
- 2011-03-01 ZA ZA2011/01590A patent/ZA201101590B/en unknown
- 2011-03-15 DO DO2011000081A patent/DOP2011000081A/es unknown
- 2011-03-15 CL CL2011000544A patent/CL2011000544A1/es unknown
- 2011-03-23 CO CO11035303A patent/CO6361998A2/es not_active Application Discontinuation
- 2011-04-12 EC EC2011010974A patent/ECSP11010974A/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010033543A3 (en) | 2010-11-18 |
US8859596B2 (en) | 2014-10-14 |
US20100069349A1 (en) | 2010-03-18 |
US20100069348A1 (en) | 2010-03-18 |
RU2011115087A (ru) | 2012-10-27 |
EP2334646A2 (en) | 2011-06-22 |
CO6361998A2 (es) | 2012-01-20 |
BRPI0919135A2 (pt) | 2015-12-08 |
ECSP11010974A (es) | 2011-05-31 |
CL2011000544A1 (es) | 2011-06-17 |
US8188135B2 (en) | 2012-05-29 |
PE20110804A1 (es) | 2011-11-30 |
EP2428507A3 (en) | 2012-06-13 |
AU2009293319A1 (en) | 2010-03-25 |
EP2428507B1 (en) | 2015-10-21 |
AR073599A1 (es) | 2010-11-17 |
AR077664A2 (es) | 2011-09-14 |
MX2011002811A (es) | 2011-04-12 |
ES2556752T3 (es) | 2016-01-20 |
CA2737199A1 (en) | 2010-03-25 |
KR20110061619A (ko) | 2011-06-09 |
PA8842501A1 (es) | 2010-04-21 |
JP2012502917A (ja) | 2012-02-02 |
IL211406A0 (en) | 2011-05-31 |
TW201016692A (en) | 2010-05-01 |
EP2896615A1 (en) | 2015-07-22 |
EP2428507A2 (en) | 2012-03-14 |
ZA201101590B (en) | 2012-08-29 |
CN102216277A (zh) | 2011-10-12 |
WO2010033543A2 (en) | 2010-03-25 |
UY32125A (es) | 2010-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DOP2011000081A (es) | Benzamida sustituida como ligandos del receptor de canabinoides | |
UY32331A (es) | Compuestos novedosos como ligandos de receptores de canabinoides | |
ECSP10010518A (es) | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 | |
ECSP088210A (es) | Bencimidazoles sustituidos y métodos de preparación | |
CO6341558A2 (es) | Antagonistas del recepptor de nmda para el tratamiento de trastornos neuropsiquiatricos | |
TN2011000279A1 (en) | Novel pyrazole -4-n-alkoxycarboxamides as microbiocides | |
EA201170252A1 (ru) | Амидофеноксиндазолы в качестве ингибиторов c-мет | |
MA32811B1 (fr) | Nouveaux composés | |
CO6382157A2 (es) | Compuestos pirazina como inhibidores de fosfodiesterasa 10 | |
UY31984A (es) | DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas. | |
CR10309A (es) | "compuestos y composiciones como inhibidores de la actividad del receptor canabinoide 1" | |
MA32505B1 (fr) | 5-alcynyl-pyrimidines | |
MX2011009780A (es) | Pirimidinas sustituidas para el tratamiento del cancer. | |
TW200942535A (en) | Novel compounds as cannabinoid receptor ligands | |
MX2010005649A (es) | Compuestos novedosos como ligandos del receptor canabinoide y sus usos. | |
MX2010001093A (es) | Herbicidas novedosos. | |
CO6382123A2 (es) | Antagonistas de la via hedgehog de ftalazina disustituida | |
ECSP11010816A (es) | Nuevos Compuestos | |
TN2012000281A1 (en) | Mglu2 agonists | |
CO6341625A2 (es) | Derivados de indol como agentes anticáncer | |
TN2011000355A1 (en) | Novel microbiocides | |
UA103197C2 (uk) | Застосування ніфуртимоксу для лікування хвороб, спричинених трихомонадами | |
CL2008001837A1 (es) | Uso de compuestos derivados de cinolin-3-carboxamida en el tratamiento de la esquizofrenia. | |
DE602008002598D1 (en) | Cyclohexylderivate | |
IN2012DN01223A (es) |