MX2009012685A - Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina. - Google Patents

Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.

Info

Publication number
MX2009012685A
MX2009012685A MX2009012685A MX2009012685A MX2009012685A MX 2009012685 A MX2009012685 A MX 2009012685A MX 2009012685 A MX2009012685 A MX 2009012685A MX 2009012685 A MX2009012685 A MX 2009012685A MX 2009012685 A MX2009012685 A MX 2009012685A
Authority
MX
Mexico
Prior art keywords
phenyl substituted
reuptake inhibitors
monoamine reuptake
compounds
synthesis
Prior art date
Application number
MX2009012685A
Other languages
English (en)
Inventor
Liming Shao
Fengjiang Wang
Scott Christopher Malcolm
Michael Charles Hewitt
Jianguo Ma
Seth Ribe
Mark A Varney
Una Campbell
Sharon Rae Engel
Larry Wendell Hardy
Patrick Koch
Rudy Schreiber
Kerry L Spear
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of MX2009012685A publication Critical patent/MX2009012685A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen los derivados de ciclohexilamina sustituidos con fenilo y los métodos para su síntesis y caracterización. Se describe en la presente el uso de estos compuestos para tratar/prevenir trastornos neurológicos, así como los métodos para su síntesis. Los compuestos ejemplares de la invención inhiben la reabsorción de monoaminas endógenas, tales como dopamina, serotonina y norepinefrina (por ejemplo, desde la hendidura sináptica) y modulan uno o más transportadores de monoamina. Se proporcionan también las formulaciones farmacéuticas que incorporan los compuestos de la invención.
MX2009012685A 2007-05-31 2008-06-02 Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina. MX2009012685A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94124207P 2007-05-31 2007-05-31
PCT/US2008/065571 WO2008151156A1 (en) 2007-05-31 2008-06-02 Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors

Publications (1)

Publication Number Publication Date
MX2009012685A true MX2009012685A (es) 2009-12-14

Family

ID=40094167

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012685A MX2009012685A (es) 2007-05-31 2008-06-02 Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.

Country Status (15)

Country Link
US (3) US8669291B2 (es)
EP (3) EP2617704B1 (es)
JP (3) JP5420534B2 (es)
KR (1) KR101581289B1 (es)
CN (3) CN108178733A (es)
AU (1) AU2008259841B2 (es)
BR (1) BRPI0811639A2 (es)
CA (1) CA2688493C (es)
HK (1) HK1200438A1 (es)
IL (1) IL202405A (es)
MX (1) MX2009012685A (es)
NZ (1) NZ580429A (es)
RU (1) RU2470011C2 (es)
WO (1) WO2008151156A1 (es)
ZA (1) ZA200907171B (es)

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JP2023528547A (ja) 2020-05-29 2023-07-04 テグ－キョンプク メディカル イノベーション ファウンデーション 少なくとも１つのｎを含む５員ヘテロアリール誘導体、ならびにこれを有効成分として含有する精神障害の予防または治療に使用するための医薬組成物
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ZA200907171B (en) 2010-12-29
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JP5420534B2 (ja) 2014-02-19
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RU2009149292A (ru) 2011-07-10
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CN103936605A (zh) 2014-07-23
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