CR11264A - Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa - Google Patents
Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasaInfo
- Publication number
- CR11264A CR11264A CR11264A CR11264A CR11264A CR 11264 A CR11264 A CR 11264A CR 11264 A CR11264 A CR 11264A CR 11264 A CR11264 A CR 11264A CR 11264 A CR11264 A CR 11264A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- kinase inhibitors
- compositions
- pirimidin
- alcoxi
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
La invencion proporciona compuestos de la formula (I): y composiciones farmaceuticas de los mismos, los cuales son utiles como inhibidores de cinasa de proteina, asi como metodos para utilizar tales compuestos con el fin de tratar, disminuir, o prevenir una condicion asociada con una actividad de cinasa anormal o mal regulada.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95726007P | 2007-08-22 | 2007-08-22 |
Publications (1)
Publication Number | Publication Date |
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CR11264A true CR11264A (es) | 2010-04-19 |
Family
ID=39929716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR11264A CR11264A (es) | 2007-08-22 | 2010-02-11 | Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa |
Country Status (24)
Country | Link |
---|---|
US (1) | US8293757B2 (es) |
EP (1) | EP2190825B1 (es) |
JP (2) | JP5599312B2 (es) |
KR (2) | KR101218926B1 (es) |
CN (1) | CN101784530A (es) |
AR (1) | AR068014A1 (es) |
AU (1) | AU2008289037B2 (es) |
BR (1) | BRPI0815715A8 (es) |
CA (1) | CA2697081C (es) |
CL (1) | CL2008002478A1 (es) |
CO (1) | CO6260074A2 (es) |
CR (1) | CR11264A (es) |
EC (1) | ECSP10010044A (es) |
ES (1) | ES2477878T3 (es) |
MA (1) | MA31704B1 (es) |
MX (1) | MX2010002004A (es) |
PE (1) | PE20090992A1 (es) |
PL (1) | PL2190825T3 (es) |
PT (1) | PT2190825E (es) |
RU (1) | RU2455288C2 (es) |
TN (1) | TN2010000087A1 (es) |
TW (1) | TW200914023A (es) |
WO (1) | WO2009026276A1 (es) |
ZA (1) | ZA201001513B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA017392B1 (ru) | 2007-08-22 | 2012-12-28 | Айрм Ллк | Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ |
EP2190825B1 (en) * | 2007-08-22 | 2014-04-09 | Irm Llc | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
MY173949A (en) | 2012-04-25 | 2020-02-28 | Takeda Pharmaceuticals Co | Nitrogenated heterocyclic compound |
WO2013192088A1 (en) * | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
US9376418B2 (en) | 2012-06-22 | 2016-06-28 | Merck Sharp & Dohme Corp. | Substituted pyridine spleen tyrosine kinase (SYK) inhibitors |
EP2873669A4 (en) | 2012-07-13 | 2015-11-25 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUND |
US9353066B2 (en) | 2012-08-20 | 2016-05-31 | Merck Sharp & Dohme Corp. | Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors |
DK3007689T3 (en) | 2013-01-10 | 2018-06-14 | Pulmokine Inc | NON-SELECTIVE KINASE INHIBITORS |
WO2014142255A1 (ja) | 2013-03-14 | 2014-09-18 | 武田薬品工業株式会社 | 複素環化合物 |
JP6411342B2 (ja) | 2013-07-03 | 2018-10-24 | 武田薬品工業株式会社 | アミド化合物 |
US10053468B2 (en) | 2013-07-03 | 2018-08-21 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
JPWO2015012328A1 (ja) | 2013-07-24 | 2017-03-02 | 武田薬品工業株式会社 | 複素環化合物 |
CN104458675A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选干细胞因子受体激酶抑制剂高通量筛选方法 |
CN104458674A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选血管内皮生长因子1激酶抑制剂高通量筛选方法 |
CN111743901B (zh) | 2013-10-11 | 2023-09-12 | 普尔莫凯恩股份有限公司 | 喷雾干燥制剂 |
US9403810B2 (en) | 2014-05-14 | 2016-08-02 | Novartis Ag | Carboxamide derivatives |
KR101694753B1 (ko) * | 2015-08-28 | 2017-01-11 | 주식회사 온코크로스 | 크로몰린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 간질환 예방 및 치료용 약학적 조성물 |
CN110087653A (zh) | 2016-10-27 | 2019-08-02 | 普尔莫凯恩股份有限公司 | 用于治疗肺高血压的组合疗法 |
KR101974145B1 (ko) * | 2017-12-22 | 2019-04-30 | 한국생명공학연구원 | 보풀 추출물을 유효성분으로 함유하는 아토피 피부염의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0164204A1 (en) * | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
US5516775A (en) | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
AU693475B2 (en) | 1993-10-01 | 1998-07-02 | Novartis Ag | Pyrimidineamine derivatives and processes for the preparation thereof |
TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
PL341984A1 (en) | 1998-01-28 | 2001-05-07 | Shionogi & Co | Novel tricycle compounds |
US7034019B2 (en) | 2000-05-08 | 2006-04-25 | Janssen Pharmaceutica N.V. | Prodrugs of HIV replication inhibiting pyrimidines |
GB0022438D0 (en) | 2000-09-13 | 2000-11-01 | Novartis Ag | Organic Compounds |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
AU2002342878A1 (en) | 2001-05-16 | 2002-11-25 | Axxima Pharmaceuticals Ag | Pyridylpyrimidine derivatives as effective compounds against prion diseases |
GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
GB0222514D0 (en) | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
US20050014753A1 (en) | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
WO2004110350A2 (en) | 2003-05-14 | 2004-12-23 | Torreypines Therapeutics, Inc. | Compouds and uses thereof in modulating amyloid beta |
WO2005020921A2 (en) | 2003-08-29 | 2005-03-10 | Exelixis, Inc. | C-kit modulators and methods of use |
ES2229928B1 (es) | 2003-10-02 | 2006-07-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirimidin-2-amina. |
EP1679309A4 (en) | 2003-10-24 | 2007-03-28 | Ono Pharmaceutical Co | ANTISTRESS MEDICAMENT AND ITS MEDICAL USE |
EP2295424B1 (en) | 2004-09-09 | 2015-10-14 | Natco Pharma Limited | Processes for the preparation of novel phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase |
KR20070084067A (ko) | 2004-10-13 | 2007-08-24 | 와이어쓰 | N-벤젠설포닐 치환 아닐리노-피리미딘 동족체 |
EP1814856A1 (en) | 2004-11-12 | 2007-08-08 | Galapagos N.V. | Nitrogen heteroaromatic compounds which bind to the active site of protein kinase enzymes |
US20090312349A1 (en) | 2004-12-23 | 2009-12-17 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
JP5118029B2 (ja) | 2005-06-14 | 2013-01-16 | タイゲン バイオテクノロジー カンパニー,リミテッド | ピリミジン化合物 |
CA2622494A1 (en) * | 2005-09-27 | 2007-04-05 | Irm Llc | Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors |
US20090181991A1 (en) * | 2005-11-03 | 2009-07-16 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
CN101622244A (zh) | 2006-11-03 | 2010-01-06 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
JP5160636B2 (ja) | 2007-05-04 | 2013-03-13 | アイアールエム・リミテッド・ライアビリティ・カンパニー | c−kitおよびPDGFRキナーゼ阻害剤としてのピリミジン誘導体および組成物 |
MX2009011951A (es) | 2007-05-04 | 2009-12-11 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa c-kit y pdgfr. |
EA017392B1 (ru) | 2007-08-22 | 2012-12-28 | Айрм Ллк | Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ |
EP2190825B1 (en) * | 2007-08-22 | 2014-04-09 | Irm Llc | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors |
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2008
- 2008-08-19 EP EP08798168.4A patent/EP2190825B1/en active Active
- 2008-08-19 CN CN200880103897A patent/CN101784530A/zh active Pending
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- 2008-08-19 AU AU2008289037A patent/AU2008289037B2/en not_active Ceased
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- 2008-08-19 WO PCT/US2008/073573 patent/WO2009026276A1/en active Application Filing
- 2008-08-19 KR KR1020127024444A patent/KR20120107538A/ko not_active Application Discontinuation
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- 2008-08-19 ES ES08798168.4T patent/ES2477878T3/es active Active
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- 2008-08-22 PE PE2008001428A patent/PE20090992A1/es not_active Application Discontinuation
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2010
- 2010-02-11 CR CR11264A patent/CR11264A/es not_active Application Discontinuation
- 2010-02-19 TN TNP2010000087A patent/TN2010000087A1/fr unknown
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Also Published As
Publication number | Publication date |
---|---|
AU2008289037B2 (en) | 2012-03-01 |
CN101784530A (zh) | 2010-07-21 |
TW200914023A (en) | 2009-04-01 |
MA31704B1 (fr) | 2010-09-01 |
BRPI0815715A8 (pt) | 2017-07-04 |
PT2190825E (pt) | 2014-07-16 |
CA2697081C (en) | 2013-04-23 |
JP5599312B2 (ja) | 2014-10-01 |
KR101218926B1 (ko) | 2013-01-04 |
CL2008002478A1 (es) | 2009-05-15 |
WO2009026276A1 (en) | 2009-02-26 |
KR20120107538A (ko) | 2012-10-02 |
ES2477878T3 (es) | 2014-07-18 |
US8293757B2 (en) | 2012-10-23 |
JP2014177486A (ja) | 2014-09-25 |
RU2455288C2 (ru) | 2012-07-10 |
RU2010110640A (ru) | 2011-09-27 |
CO6260074A2 (es) | 2011-03-22 |
ZA201001513B (en) | 2010-10-27 |
AU2008289037A1 (en) | 2009-02-26 |
ECSP10010044A (es) | 2010-04-30 |
TN2010000087A1 (en) | 2011-09-26 |
US20110301175A1 (en) | 2011-12-08 |
KR20100043288A (ko) | 2010-04-28 |
EP2190825B1 (en) | 2014-04-09 |
JP2010536867A (ja) | 2010-12-02 |
PE20090992A1 (es) | 2009-08-14 |
CA2697081A1 (en) | 2009-02-26 |
MX2010002004A (es) | 2010-03-11 |
AR068014A1 (es) | 2009-10-28 |
PL2190825T3 (pl) | 2014-09-30 |
BRPI0815715A2 (pt) | 2017-06-13 |
EP2190825A1 (en) | 2010-06-02 |
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