PA8792401A1 - Fenilendiaminas - Google Patents

Fenilendiaminas

Info

Publication number
PA8792401A1
PA8792401A1 PA20088792401A PA8792401A PA8792401A1 PA 8792401 A1 PA8792401 A1 PA 8792401A1 PA 20088792401 A PA20088792401 A PA 20088792401A PA 8792401 A PA8792401 A PA 8792401A PA 8792401 A1 PA8792401 A1 PA 8792401A1
Authority
PA
Panama
Prior art keywords
phenilendiamins
formula compounds
provides
mdm2
inhibitor
Prior art date
Application number
PA20088792401A
Other languages
English (en)
Inventor
Pierre-Henri Storck
Carina Leys
Bruno Schoentjes
Alain Philippe Poncelet
Virginie Sophie Poncelet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PA8792401A1 publication Critical patent/PA8792401A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DE FÓRMULA (I), SU USO COMO INHIBIDOR DE UNA INTERACCIÓN ENTRE P53-MDM2 ASÍ COMO TAMBIÉN PROPORCIONA COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS DE FÓRMULA (I).
PA20088792401A 2007-08-06 2008-08-05 Fenilendiaminas PA8792401A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07113878 2007-08-06

Publications (1)

Publication Number Publication Date
PA8792401A1 true PA8792401A1 (es) 2009-03-31

Family

ID=38872012

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088792401A PA8792401A1 (es) 2007-08-06 2008-08-05 Fenilendiaminas

Country Status (10)

Country Link
US (1) US8853406B2 (es)
EP (1) EP2185541B1 (es)
AR (1) AR067813A1 (es)
CL (1) CL2008002316A1 (es)
ES (1) ES2534899T3 (es)
PA (1) PA8792401A1 (es)
PE (1) PE20090512A1 (es)
TW (1) TW200922557A (es)
UY (1) UY31273A1 (es)
WO (1) WO2009019274A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2704B1 (en) 2007-09-21 2013-03-03 جانسين فارماسوتيكا ان في Interference inhibition factors between MD2 and B53
US8541442B2 (en) 2009-02-04 2013-09-24 Janssen Pharmaceutica N.V. Indole derivatives as anticancer agents
US9719970B2 (en) 2012-11-30 2017-08-01 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin D metabolites
BR112015013611A2 (pt) 2012-12-20 2017-11-14 Merck Sharp & Dohme composto, e, composição farmacêutica
BR122019024759B1 (pt) 2013-01-15 2022-02-08 Incyte Holdings Corporation Compostos de tiazolacarboxamidas e piridinacarboxamida, composição compreendendo os mesmos, método de inibição da enzima pim1, pim2, ou pim3, e usos dos referidos compostos
TWI734699B (zh) * 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
US9920032B2 (en) 2015-10-02 2018-03-20 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO863197A0 (en) 1997-08-18 1997-09-11 Fujisawa Pharmaceutical Co., Ltd. Novel derivatives
US6309492B1 (en) 1998-09-16 2001-10-30 Marc A. Seidner Polymer fill coating for laminate or composite wood products and method of making same
UA71587C2 (uk) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Аміди антранілової кислоти та їхнє застосування як лікарських засобів
KR20010086073A (ko) 1998-12-02 2001-09-07 데이비드 존 우드 ｐ53계 단백질의 배좌 안정성을 회복하기 위한 방법 및조성물
AU1734401A (en) 1999-12-09 2001-06-18 Mitsubishi Pharma Corporation Carboxyamido derivatives
ATE420873T1 (de) 2000-09-15 2009-01-15 Anormed Inc Chemokin rezeptor bindenden heterozyklische verbindungen
ES2292758T3 (es) 2001-03-29 2008-03-16 Eli Lilly And Company N-(2-ariletil) bencilaminas como antagonistas del receptor 5-ht6.
WO2003040402A2 (en) 2001-11-09 2003-05-15 The Regents Of The University Of California Alpha-helix mimicry by a class of organic molecules
PL370176A1 (en) 2001-11-13 2005-05-16 3-Dimensional Pharmaceuticals, Inc. Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
DE60225719T2 (de) 2001-12-18 2009-04-23 F. Hoffmann-La Roche Ag Cis-2,4,5- triphenyl-imidazoline und ihre verwendung bei der behandlung von tumoren
GB0215650D0 (en) 2002-07-05 2002-08-14 Cyclacel Ltd Bisarylsufonamide compounds
KR101331786B1 (ko) 2004-09-22 2013-11-21 얀센 파마슈티카 엔.브이. Ｍｄｍ2 및 ｐ53간의 상호작용 저해제

Also Published As

Publication number Publication date
TW200922557A (en) 2009-06-01
CL2008002316A1 (es) 2009-07-17
EP2185541A1 (en) 2010-05-19
EP2185541B1 (en) 2015-01-28
WO2009019274A1 (en) 2009-02-12
AR067813A1 (es) 2009-10-21
US8853406B2 (en) 2014-10-07
PE20090512A1 (es) 2009-04-29
ES2534899T3 (es) 2015-04-30
US20110130418A1 (en) 2011-06-02
UY31273A1 (es) 2009-03-02

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