NO20040151L - Ny fremgangsmåte for syntese av (2S,3aS,7aS)-1-[(S)-alanyl]-oktahydro-1H-indol-2-karboksylsyreforbindelser og anvendelse i syntese av perindopril - Google Patents

Ny fremgangsmåte for syntese av (2S,3aS,7aS)-1-[(S)-alanyl]-oktahydro-1H-indol-2-karboksylsyreforbindelser og anvendelse i syntese av perindopril

Info

Publication number
NO20040151L
NO20040151L NO20040151A NO20040151A NO20040151L NO 20040151 L NO20040151 L NO 20040151L NO 20040151 A NO20040151 A NO 20040151A NO 20040151 A NO20040151 A NO 20040151A NO 20040151 L NO20040151 L NO 20040151L
Authority
NO
Norway
Prior art keywords
synthesis
perindopril
alanyl
octahydro
indole
Prior art date
Application number
NO20040151A
Other languages
English (en)
Other versions
NO328234B1 (no
Inventor
Tibor Mezei
Gyula Simig
Márta Porcs-Makkay
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20040151(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20040151L publication Critical patent/NO20040151L/no
Publication of NO328234B1 publication Critical patent/NO328234B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

Oppfinnelsen vedrører en fremgangsmåte for industriell syntese av forbindelser med formel (I) hvori Ri representerer et hydrogenatom eller en lineær eller forgrenet alkyl- eller benzylgruppe, og Rrepresenterer en gruppe som beskytter aminofunksjonen. Oppfinnelsen vedrører også anvendelsen av den samme i industriell syntese av perindopril med formel (II) og i dets farmasøytisk akseptable salter.
NO20040151A 2001-07-24 2004-01-13 Ny fremgangsmate for syntese av (2S,3aS,7aS)-1-[(S)-alanyl]-oktahydro-1H-indol-2-karboksylsyreforbindelser og anvendelse i syntese av perindopril NO328234B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109839A FR2827860B1 (fr) 2001-07-24 2001-07-24 Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
PCT/FR2002/002627 WO2003016336A1 (fr) 2001-07-24 2002-07-23 NOUVEAU PROCEDE DE SYNTHESE DE DERIVES DE L'ACIDE (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIQUE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL

Publications (2)

Publication Number Publication Date
NO20040151L true NO20040151L (no) 2004-01-13
NO328234B1 NO328234B1 (no) 2010-01-11

Family

ID=8865826

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20040151A NO328234B1 (no) 2001-07-24 2004-01-13 Ny fremgangsmate for syntese av (2S,3aS,7aS)-1-[(S)-alanyl]-oktahydro-1H-indol-2-karboksylsyreforbindelser og anvendelse i syntese av perindopril

Country Status (25)

Country Link
US (1) US7060842B2 (no)
EP (1) EP1256590B1 (no)
JP (1) JP3868957B2 (no)
KR (1) KR100607556B1 (no)
CN (1) CN1533398A (no)
AR (1) AR035081A1 (no)
AT (1) ATE318838T1 (no)
AU (1) AU2002334027B8 (no)
BR (1) BR0211334A (no)
CA (1) CA2455706C (no)
DE (1) DE60209458T2 (no)
DK (1) DK1256590T3 (no)
EA (1) EA005490B1 (no)
ES (1) ES2259071T3 (no)
FR (1) FR2827860B1 (no)
HU (1) HU229396B1 (no)
MA (1) MA27130A1 (no)
MX (1) MXPA04000443A (no)
NO (1) NO328234B1 (no)
NZ (1) NZ530427A (no)
PL (1) PL212408B1 (no)
PT (1) PT1256590E (no)
SI (1) SI1256590T1 (no)
WO (1) WO2003016336A1 (no)
ZA (1) ZA200400246B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2289060T3 (es) * 2002-01-30 2008-02-01 Les Laboratoires Servier Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis.
SI1338591T1 (sl) * 2003-02-28 2006-02-28 Servier Lab NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA
PT1403277E (pt) * 2003-02-28 2005-11-30 Servier Lab Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril
US7521566B2 (en) 2003-02-28 2009-04-21 Les Laboratoires Servier Process for preparation of perindopril and salts thereof
SI1403275T1 (sl) * 2003-02-28 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
DK1323729T3 (da) * 2003-03-12 2005-02-14 Servier Lab Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril
SI1323729T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
ES2240919T3 (es) * 2003-03-12 2005-10-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
PL1636185T3 (pl) 2003-06-24 2012-12-31 Servier Lab Nowe formy krystaliczne peryndoprylu erbuminy
DK1367063T3 (da) * 2003-07-31 2006-12-27 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
JP4720132B2 (ja) * 2003-10-30 2011-07-13 住友化学株式会社 光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko) 2006-12-19 2013-11-15 에스케이바이오팜 주식회사 옥타하이드로인돌-2-카르복시산의 제조방법
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0308341A1 (fr) * 1987-09-17 1989-03-22 Adir Et Compagnie Procédé de synthèse industrielle du périndopril et de ses principaux intermédiaires de synthèse

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0308341A1 (fr) * 1987-09-17 1989-03-22 Adir Et Compagnie Procédé de synthèse industrielle du périndopril et de ses principaux intermédiaires de synthèse

Also Published As

Publication number Publication date
DE60209458D1 (de) 2006-04-27
NZ530427A (en) 2005-08-26
US20040198988A1 (en) 2004-10-07
PL212408B1 (pl) 2012-09-28
FR2827860A1 (fr) 2003-01-31
AU2002334027A1 (en) 2003-03-03
KR20040023673A (ko) 2004-03-18
PL355159A1 (en) 2003-01-13
HU0202437D0 (no) 2002-10-28
CA2455706C (fr) 2012-01-24
ZA200400246B (en) 2006-07-26
EP1256590A1 (fr) 2002-11-13
MXPA04000443A (es) 2004-03-18
KR100607556B1 (ko) 2006-08-02
BR0211334A (pt) 2004-09-28
CN1533398A (zh) 2004-09-29
JP3868957B2 (ja) 2007-01-17
EA200400110A1 (ru) 2004-06-24
HUP0202437A3 (en) 2003-05-28
MA27130A1 (fr) 2005-01-03
AR035081A1 (es) 2004-04-14
EA005490B1 (ru) 2005-02-24
AU2002334027B8 (en) 2007-01-25
EP1256590B1 (fr) 2006-03-01
HU229396B1 (hu) 2013-11-28
HUP0202437A2 (hu) 2003-02-28
WO2003016336A1 (fr) 2003-02-27
ATE318838T1 (de) 2006-03-15
US7060842B2 (en) 2006-06-13
DK1256590T3 (da) 2006-06-06
NO328234B1 (no) 2010-01-11
AU2002334027B2 (en) 2006-12-14
ES2259071T3 (es) 2006-09-16
DE60209458T2 (de) 2006-10-12
FR2827860B1 (fr) 2004-12-10
SI1256590T1 (sl) 2006-06-30
PT1256590E (pt) 2006-06-30
CA2455706A1 (fr) 2003-02-27
JP2005500386A (ja) 2005-01-06

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