NO20060922L - Ny fremgangsmate for syntesen av perindopril og dens farmasoytiske akseptable salter - Google Patents

Ny fremgangsmate for syntesen av perindopril og dens farmasoytiske akseptable salter

Info

Publication number
NO20060922L
NO20060922L NO20060922A NO20060922A NO20060922L NO 20060922 L NO20060922 L NO 20060922L NO 20060922 A NO20060922 A NO 20060922A NO 20060922 A NO20060922 A NO 20060922A NO 20060922 L NO20060922 L NO 20060922L
Authority
NO
Norway
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
new method
Prior art date
Application number
NO20060922A
Other languages
English (en)
Other versions
NO333957B1 (no
Inventor
Claude Fugier
Pascal Langlois
Thierry Dubuffet
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20060922L publication Critical patent/NO20060922L/no
Publication of NO333957B1 publication Critical patent/NO333957B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Fremgangsmåte for syntesen av perindopril med formel (I): og dens farmasøytisk akseptable salter.
NO20060922A 2003-07-31 2006-02-24 Fremgangsmåte for syntesen av perindopril og dens farmasøytiske akseptable salter NO333957B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03291931A EP1367063B1 (fr) 2003-07-31 2003-07-31 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/002035 WO2005012333A2 (fr) 2003-07-31 2004-07-29 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
NO20060922L true NO20060922L (no) 2006-02-24
NO333957B1 NO333957B1 (no) 2013-10-28

Family

ID=29414890

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060922A NO333957B1 (no) 2003-07-31 2006-02-24 Fremgangsmåte for syntesen av perindopril og dens farmasøytiske akseptable salter

Country Status (28)

Country Link
US (1) US7358372B2 (no)
EP (1) EP1367063B1 (no)
JP (1) JP4263743B2 (no)
KR (1) KR100798560B1 (no)
CN (1) CN100404548C (no)
AR (1) AR045151A1 (no)
AT (1) ATE337332T1 (no)
AU (1) AU2004261439B2 (no)
BR (1) BRPI0413169A (no)
CA (1) CA2533005C (no)
CY (1) CY1105791T1 (no)
DE (1) DE60307721T2 (no)
DK (1) DK1367063T3 (no)
EA (1) EA008685B1 (no)
ES (1) ES2271498T3 (no)
GE (1) GEP20094740B (no)
HK (1) HK1096406A1 (no)
MA (1) MA27911A1 (no)
MX (1) MXPA06001243A (no)
MY (1) MY139443A (no)
NO (1) NO333957B1 (no)
NZ (1) NZ544879A (no)
PL (1) PL211892B1 (no)
PT (1) PT1367063E (no)
SI (1) SI1367063T1 (no)
UA (1) UA80905C2 (no)
WO (1) WO2005012333A2 (no)
ZA (1) ZA200600479B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8604144A1 (es) * 1984-11-21 1986-01-16 Farmhispania Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
AU2004261439B2 (en) 2008-03-13
ZA200600479B (en) 2007-05-30
EA200600250A1 (ru) 2006-06-30
EP1367063B1 (fr) 2006-08-23
CN1826352A (zh) 2006-08-30
KR20060032209A (ko) 2006-04-14
UA80905C2 (en) 2007-11-12
HK1096406A1 (en) 2007-06-01
MXPA06001243A (es) 2006-04-11
CY1105791T1 (el) 2011-02-02
AU2004261439A1 (en) 2005-02-10
DE60307721D1 (de) 2006-10-05
ATE337332T1 (de) 2006-09-15
EP1367063A1 (fr) 2003-12-03
DK1367063T3 (da) 2006-12-27
NO333957B1 (no) 2013-10-28
JP2007526896A (ja) 2007-09-20
US7358372B2 (en) 2008-04-15
KR100798560B1 (ko) 2008-01-28
CA2533005A1 (fr) 2005-02-10
WO2005012333A2 (fr) 2005-02-10
DE60307721T2 (de) 2007-10-18
MY139443A (en) 2009-10-30
BRPI0413169A (pt) 2006-10-03
JP4263743B2 (ja) 2009-05-13
WO2005012333A3 (fr) 2005-03-24
GEP20094740B (en) 2009-07-27
CN100404548C (zh) 2008-07-23
NZ544879A (en) 2009-03-31
PL211892B1 (pl) 2012-07-31
CA2533005C (fr) 2010-04-06
AR045151A1 (es) 2005-10-19
EA008685B1 (ru) 2007-06-29
MA27911A1 (fr) 2006-05-02
ES2271498T3 (es) 2007-04-16
PT1367063E (pt) 2006-12-29
US20060183920A1 (en) 2006-08-17
SI1367063T1 (sl) 2006-10-31
PL379631A1 (pl) 2006-10-30

Similar Documents

Publication Publication Date Title
NO20062599L (no) Fremgangsmate for syntese av perindopril og farmasoytisk akseptable salter derav
JO2282B1 (en) Oxazole derivatives
NO20054852L (no) GFAT inhibitorer
NO20061454L (no) Compounds having CRTH2 antagonist activity
NO20066055L (no) Pyridinderivater
NO20073465L (no) Benzotiazol-derivater
NO20054669L (no) Substituerte kinobenzoxazinanaloger
NO20055257L (no) Ny fremgangsmate for syntesen av s-indolin-2-karboksylsyre og anvendelse derav i syntesen av perindopril
NO20063576L (no) 1,3-dioksanederivativer og analoge forbindelser for behandling av fedme og diabetes
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
NO20065873L (no) 3-(4-(2-dihydroisoksazol-3-ylpyridin-5-yl)fenyl)-5-triazol-1-ylmetyloksoazolidin-2-on derivater som MAO inhibitorer i behandlingen av bakterielle infeksjoner
DE602005011267D1 (de) Benzofuran- und benzothiophenderivate, die sich für die behandlung von herzkreislauferkrankungen eignen
MY136938A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
MY139159A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
NO20063012L (no) Fremgangsmaten for syntesen av perindopril og farmasoytisk akseptable salter derav
NO20053673L (no) Nye antikonvulsanderivatsalter
NO20060922L (no) Ny fremgangsmate for syntesen av perindopril og dens farmasoytiske akseptable salter
MY139348A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
MY136288A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
NO20071466L (no) 3-substituerte-5- og 6-aminoalkyl indol-2-karboksylsyreamider og relaterte analoger som inhibitorer av kaseinkinase IE
MY136638A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
MY139098A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
MY136989A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
ATE412416T1 (de) Indolin-2-one-pyridin-derivate, herstellung und therapeutische verwendung dafür

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees