ES8604144A1 - Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico - Google Patents
Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilicoInfo
- Publication number
- ES8604144A1 ES8604144A1 ES537841A ES537841A ES8604144A1 ES 8604144 A1 ES8604144 A1 ES 8604144A1 ES 537841 A ES537841 A ES 537841A ES 537841 A ES537841 A ES 537841A ES 8604144 A1 ES8604144 A1 ES 8604144A1
- Authority
- ES
- Spain
- Prior art keywords
- carboxylic acid
- hexa
- hydro
- indoline
- acid deriv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO (2S, 3AS, 7AS)-1-(S)-N-(S)-1-ETOXICARBONIL-3-FENILPROPILALANILEXAHIDRO-2-INDOLINCARBOXILICO, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR EL (S)-4-FENIL-2-1MINOBUTIRATO DE ETILO, DE FORMULA GENERAL (II), CON EL ACIDO (2S, 3AS, 7AS)-N-2-(R,S)-2-BROMOPROPIONIL-EXAHIDRO-2-INDOLINCARBOXILICO, PARA OBTENER UN COMPUESTO INTERMEDIO DE FORMULA GENERAL (III). EL COMPUESTO INTERMEDIO OBTENIDO DE FORMULA GENERAL (III) SE SOMETE A SEPARACION OPTICA, PARA OBTENER EL COMPUESTO DE FORMULA GENERAL (I). DE APLICACION EN FARMACIA POR SUS PROPIEDADES ANTIHIPERTENSIVAS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES537841A ES8604144A1 (es) | 1984-11-21 | 1984-11-21 | Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES537841A ES8604144A1 (es) | 1984-11-21 | 1984-11-21 | Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604144A1 true ES8604144A1 (es) | 1986-01-16 |
ES537841A0 ES537841A0 (es) | 1986-01-16 |
Family
ID=8488170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537841A Expired ES8604144A1 (es) | 1984-11-21 | 1984-11-21 | Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8604144A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005012333A3 (fr) * | 2003-07-31 | 2005-03-24 | Servier Lab | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
WO2005012328A3 (fr) * | 2003-07-31 | 2005-03-24 | Servier Lab | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
-
1984
- 1984-11-21 ES ES537841A patent/ES8604144A1/es not_active Expired
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005012333A3 (fr) * | 2003-07-31 | 2005-03-24 | Servier Lab | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
WO2005012328A3 (fr) * | 2003-07-31 | 2005-03-24 | Servier Lab | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
EA008685B1 (ru) * | 2003-07-31 | 2007-06-29 | Ле Лаборатуар Сервье | Способ синтеза периндоприла и его фармацевтически приемлемых солей |
EA008644B1 (ru) * | 2003-07-31 | 2007-06-29 | Ле Лаборатуар Сервье | Способ синтеза периндоприла и его фармацевтически приемлемых солей |
AU2004261439B2 (en) * | 2003-07-31 | 2008-03-13 | Les Laboratoires Servier | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof |
US7358372B2 (en) | 2003-07-31 | 2008-04-15 | Les Laboratories Servier | Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof |
US7368580B2 (en) | 2003-07-31 | 2008-05-06 | Les Laboratories Servier | Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof |
CN100404548C (zh) * | 2003-07-31 | 2008-07-23 | 瑟维尔实验室 | 合成培哚普利及其药学可接受盐的新方法 |
AU2004261440B2 (en) * | 2003-07-31 | 2008-07-31 | Les Laboratoires Servier | Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof |
Also Published As
Publication number | Publication date |
---|---|
ES537841A0 (es) | 1986-01-16 |
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