ES8604144A1 - Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico - Google Patents

Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico

Info

Publication number
ES8604144A1
ES8604144A1 ES537841A ES537841A ES8604144A1 ES 8604144 A1 ES8604144 A1 ES 8604144A1 ES 537841 A ES537841 A ES 537841A ES 537841 A ES537841 A ES 537841A ES 8604144 A1 ES8604144 A1 ES 8604144A1
Authority
ES
Spain
Prior art keywords
carboxylic acid
hexa
hydro
indoline
acid deriv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537841A
Other languages
English (en)
Other versions
ES537841A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Farmhispania SA
Original Assignee
Bioiberica SA
Farmhispania SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA, Farmhispania SA filed Critical Bioiberica SA
Priority to ES537841A priority Critical patent/ES8604144A1/es
Publication of ES8604144A1 publication Critical patent/ES8604144A1/es
Publication of ES537841A0 publication Critical patent/ES537841A0/es
Expired legal-status Critical Current

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Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO (2S, 3AS, 7AS)-1-(S)-N-(S)-1-ETOXICARBONIL-3-FENILPROPILALANILEXAHIDRO-2-INDOLINCARBOXILICO, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR EL (S)-4-FENIL-2-1MINOBUTIRATO DE ETILO, DE FORMULA GENERAL (II), CON EL ACIDO (2S, 3AS, 7AS)-N-2-(R,S)-2-BROMOPROPIONIL-EXAHIDRO-2-INDOLINCARBOXILICO, PARA OBTENER UN COMPUESTO INTERMEDIO DE FORMULA GENERAL (III). EL COMPUESTO INTERMEDIO OBTENIDO DE FORMULA GENERAL (III) SE SOMETE A SEPARACION OPTICA, PARA OBTENER EL COMPUESTO DE FORMULA GENERAL (I). DE APLICACION EN FARMACIA POR SUS PROPIEDADES ANTIHIPERTENSIVAS.
ES537841A 1984-11-21 1984-11-21 Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico Expired ES8604144A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES537841A ES8604144A1 (es) 1984-11-21 1984-11-21 Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES537841A ES8604144A1 (es) 1984-11-21 1984-11-21 Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico

Publications (2)

Publication Number Publication Date
ES8604144A1 true ES8604144A1 (es) 1986-01-16
ES537841A0 ES537841A0 (es) 1986-01-16

Family

ID=8488170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537841A Expired ES8604144A1 (es) 1984-11-21 1984-11-21 Procedimiento para la obtencion del acido (2s, 3as, 7as)-1-((s)-1-etoxicarbonil-3-fenilpropil) alanil) exahidro-2-indolincarboxilico

Country Status (1)

Country Link
ES (1) ES8604144A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012333A3 (fr) * 2003-07-31 2005-03-24 Servier Lab Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
WO2005012328A3 (fr) * 2003-07-31 2005-03-24 Servier Lab Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012333A3 (fr) * 2003-07-31 2005-03-24 Servier Lab Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
WO2005012328A3 (fr) * 2003-07-31 2005-03-24 Servier Lab Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
EA008685B1 (ru) * 2003-07-31 2007-06-29 Ле Лаборатуар Сервье Способ синтеза периндоприла и его фармацевтически приемлемых солей
EA008644B1 (ru) * 2003-07-31 2007-06-29 Ле Лаборатуар Сервье Способ синтеза периндоприла и его фармацевтически приемлемых солей
AU2004261439B2 (en) * 2003-07-31 2008-03-13 Les Laboratoires Servier Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
US7358372B2 (en) 2003-07-31 2008-04-15 Les Laboratories Servier Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
US7368580B2 (en) 2003-07-31 2008-05-06 Les Laboratories Servier Method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
CN100404548C (zh) * 2003-07-31 2008-07-23 瑟维尔实验室 合成培哚普利及其药学可接受盐的新方法
AU2004261440B2 (en) * 2003-07-31 2008-07-31 Les Laboratoires Servier Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof

Also Published As

Publication number Publication date
ES537841A0 (es) 1986-01-16

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