NO20050664L - 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer - Google Patents

2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer

Info

Publication number
NO20050664L
NO20050664L NO20050664A NO20050664A NO20050664L NO 20050664 L NO20050664 L NO 20050664L NO 20050664 A NO20050664 A NO 20050664A NO 20050664 A NO20050664 A NO 20050664A NO 20050664 L NO20050664 L NO 20050664L
Authority
NO
Norway
Prior art keywords
modulators
substituted indoles
compound
formula
methods
Prior art date
Application number
NO20050664A
Other languages
English (en)
Inventor
Ann Marie Madera
Robert James Weikert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20050664L publication Critical patent/NO20050664L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Foreliggende oppfinnelse tilveiebringer en forbindelse med formelen: S(0)-R' I et farmasøytisk akseptabelt salt eller et prodmg derav, hvor R', R^, R^ R*, p og n er de som er definert heri. Foreliggende oppfitmelse tilveiebringer også blandinger omfattende, metoder for anvendelse og metoder for fremstilling av forbindelse ifølge formel I.
NO20050664A 2002-09-17 2005-02-08 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer NO20050664L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41148002P 2002-09-17 2002-09-17
PCT/EP2003/009969 WO2004026831A1 (en) 2002-09-17 2003-09-08 2,4-substituted indoles and their use as 5-ht6 modulators

Publications (1)

Publication Number Publication Date
NO20050664L true NO20050664L (no) 2005-04-15

Family

ID=32030683

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050664A NO20050664L (no) 2002-09-17 2005-02-08 2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer

Country Status (24)

Country Link
US (1) US7381739B2 (no)
EP (1) EP1542973B1 (no)
JP (1) JP4267573B2 (no)
KR (1) KR100686757B1 (no)
CN (1) CN1301970C (no)
AR (1) AR041256A1 (no)
AT (1) ATE402923T1 (no)
AU (1) AU2003267063B2 (no)
BR (1) BR0314363A (no)
CA (1) CA2498946A1 (no)
DE (1) DE60322551D1 (no)
ES (1) ES2311721T3 (no)
HK (1) HK1083497A1 (no)
HR (1) HRP20050213A2 (no)
MX (1) MXPA05002836A (no)
NO (1) NO20050664L (no)
NZ (1) NZ538047A (no)
PA (1) PA8582101A1 (no)
PL (1) PL376022A1 (no)
RU (1) RU2326112C2 (no)
TW (1) TWI250150B (no)
UY (1) UY27979A1 (no)
WO (1) WO2004026831A1 (no)
ZA (1) ZA200501175B (no)

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PT1956004E (pt) 2002-03-27 2012-08-31 Glaxo Group Ltd Derivados de quinolina e sua utilização como ligandos 5-ht6
KR20050073560A (ko) * 2002-10-18 2005-07-14 에프. 호프만-라 로슈 아게 5-ｈｔ6 수용체 친화성을 갖는 4-피페라진일 벤젠설폰일인돌
EP1558582B1 (en) 2003-07-22 2005-12-21 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
MXPA06007172A (es) * 2003-12-23 2006-08-23 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-bencilamina como ssri.
CA2563895C (en) * 2004-04-13 2012-10-16 Synta Pharmaceuticals Corp. Disalt inhibitors of il-12 production
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
GB0422263D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds
US7629473B2 (en) * 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
EP2084131A1 (en) * 2006-11-09 2009-08-05 F. Hoffmann-Roche AG Indole and benzofuran 2-carboxamide derivatives
AU2008244576A1 (en) * 2007-04-26 2008-11-06 Merck Sharp & Dohme Corp. 2-substituted indole derivatives as calcium channel blockers
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
US9499484B2 (en) * 2012-04-02 2016-11-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Indole, indoline derivatives, compositions comprising them and uses thereof
EP3083588B1 (en) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
CN105541693B (zh) 2014-07-08 2018-10-16 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
KR20180022792A (ko) 2015-06-12 2018-03-06 엑소반트 사이언시즈 게엠베하 렘 수면 행동 장애의 예방 및 치료에 유용한 디아릴 및 아릴헤테로아릴 우레아 유도체
CN108472285A (zh) 2015-07-15 2018-08-31 阿速万科学有限责任公司 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3155008B2 (ja) * 1994-07-26 2001-04-09 ファイザー・インコーポレーテッド セロトニンアゴニストおよびアンタゴニストとしての４−インドール誘導体
US6114532A (en) 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
US6436964B1 (en) 1998-06-30 2002-08-20 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
IL154685A0 (en) * 2000-10-20 2003-09-17 Biovitrum Ab 2-,3-,4-, or 5-substituted-n1-(benzensulfonyl) indoles and their use in therapy
BR0115102B1 (pt) * 2000-11-02 2013-11-26 Compostos 1-aril- ou 1-alquilsulfonil-heterociclilbenzazóis e composição compreendendo os mesmos
AU2002220715A1 (en) * 2000-11-24 2002-06-03 Smithkline Beecham Plc Indolsulfonyl compounds useful in the treatment of cns disorders
US6787568B1 (en) * 2000-11-27 2004-09-07 Phoenix Scientific, Inc. Antibiotic/analgesic formulation and a method of making this formulation
US7943639B2 (en) 2002-06-20 2011-05-17 Proximagen Limited Compounds

Also Published As

Publication number Publication date
AU2003267063A1 (en) 2004-04-08
MXPA05002836A (es) 2005-05-27
HRP20050213A2 (en) 2006-12-31
NZ538047A (en) 2007-10-26
US20040072844A1 (en) 2004-04-15
TWI250150B (en) 2006-03-01
EP1542973A1 (en) 2005-06-22
ZA200501175B (en) 2007-03-28
AU2003267063B2 (en) 2009-08-06
KR20050057356A (ko) 2005-06-16
HK1083497A1 (en) 2006-07-07
JP2006502177A (ja) 2006-01-19
CN1301970C (zh) 2007-02-28
TW200413313A (en) 2004-08-01
EP1542973B1 (en) 2008-07-30
PL376022A1 (en) 2005-12-12
CA2498946A1 (en) 2004-04-01
ATE402923T1 (de) 2008-08-15
UY27979A1 (es) 2004-03-31
WO2004026831A1 (en) 2004-04-01
CN1681783A (zh) 2005-10-12
PA8582101A1 (es) 2004-04-23
RU2005111590A (ru) 2005-11-20
BR0314363A (pt) 2005-07-19
RU2326112C2 (ru) 2008-06-10
DE60322551D1 (de) 2008-09-11
AR041256A1 (es) 2005-05-11
ES2311721T3 (es) 2009-02-16
KR100686757B1 (ko) 2007-02-26
JP4267573B2 (ja) 2009-05-27
US7381739B2 (en) 2008-06-03

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