MXPA04000443A - Metodo novedoso para la sintesis de derivados del acido (2s, 3as, 7as)-1-[(s)-alanil]-octahidro-1h-indol-2-carboxilico y la aplicacion en la sintesis de perindopril. - Google Patents

Metodo novedoso para la sintesis de derivados del acido (2s, 3as, 7as)-1-[(s)-alanil]-octahidro-1h-indol-2-carboxilico y la aplicacion en la sintesis de perindopril.

Info

Publication number
MXPA04000443A
MXPA04000443A MXPA04000443A MXPA04000443A MXPA04000443A MX PA04000443 A MXPA04000443 A MX PA04000443A MX PA04000443 A MXPA04000443 A MX PA04000443A MX PA04000443 A MXPA04000443 A MX PA04000443A MX PA04000443 A MXPA04000443 A MX PA04000443A
Authority
MX
Mexico
Prior art keywords
synthesis
alanyl
octahydro
novel method
formula
Prior art date
Application number
MXPA04000443A
Other languages
English (en)
Inventor
Mezei Tibor
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA04000443(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of MXPA04000443A publication Critical patent/MXPA04000443A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento para la sintesis industrial de los compuestos de la formula (I): (ver formula) en donde R1 representa un atomo de hidrogeno o un grupo de alquilo o de bencilo, y R2 representa un grupo que protege la funcion de amino. La invencion tambien se refiere al uso del mismo para la sintesis del perindopril de la formula (II) y sus sales aceptables farmaceuticamente.
MXPA04000443A 2001-07-24 2002-07-23 Metodo novedoso para la sintesis de derivados del acido (2s, 3as, 7as)-1-[(s)-alanil]-octahidro-1h-indol-2-carboxilico y la aplicacion en la sintesis de perindopril. MXPA04000443A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109839A FR2827860B1 (fr) 2001-07-24 2001-07-24 Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
PCT/FR2002/002627 WO2003016336A1 (fr) 2001-07-24 2002-07-23 NOUVEAU PROCEDE DE SYNTHESE DE DERIVES DE L'ACIDE (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIQUE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL

Publications (1)

Publication Number Publication Date
MXPA04000443A true MXPA04000443A (es) 2004-03-18

Family

ID=8865826

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000443A MXPA04000443A (es) 2001-07-24 2002-07-23 Metodo novedoso para la sintesis de derivados del acido (2s, 3as, 7as)-1-[(s)-alanil]-octahidro-1h-indol-2-carboxilico y la aplicacion en la sintesis de perindopril.

Country Status (25)

Country Link
US (1) US7060842B2 (es)
EP (1) EP1256590B1 (es)
JP (1) JP3868957B2 (es)
KR (1) KR100607556B1 (es)
CN (1) CN1533398A (es)
AR (1) AR035081A1 (es)
AT (1) ATE318838T1 (es)
AU (1) AU2002334027B8 (es)
BR (1) BR0211334A (es)
CA (1) CA2455706C (es)
DE (1) DE60209458T2 (es)
DK (1) DK1256590T3 (es)
EA (1) EA005490B1 (es)
ES (1) ES2259071T3 (es)
FR (1) FR2827860B1 (es)
HU (1) HU229396B1 (es)
MA (1) MA27130A1 (es)
MX (1) MXPA04000443A (es)
NO (1) NO328234B1 (es)
NZ (1) NZ530427A (es)
PL (1) PL212408B1 (es)
PT (1) PT1256590E (es)
SI (1) SI1256590T1 (es)
WO (1) WO2003016336A1 (es)
ZA (1) ZA200400246B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2289060T3 (es) 2002-01-30 2008-02-01 Les Laboratoires Servier Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis.
DK1403275T3 (da) * 2003-02-28 2005-12-05 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
PT1403277E (pt) * 2003-02-28 2005-11-30 Servier Lab Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril
CA2517205C (en) 2003-02-28 2010-08-24 Lupin Limited Process for preparation of perindopril and salts thereof
DE60301980T2 (de) 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril
ES2231760T3 (es) * 2003-03-12 2005-05-16 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
DK1321471T3 (da) * 2003-03-12 2005-08-29 Servier Lab Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
SI1319668T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
KR20060035636A (ko) 2003-06-24 2006-04-26 르 라보레또레 쎄르비에르 신규한 결정형의 페린도프릴 에르부민
PT1367063E (pt) * 2003-07-31 2006-12-29 Servier Lab Novo processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis
JP4720132B2 (ja) * 2003-10-30 2011-07-13 住友化学株式会社 光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko) 2006-12-19 2013-11-15 에스케이바이오팜 주식회사 옥타하이드로인돌-2-카르복시산의 제조방법
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
HUP0202437A3 (en) 2003-05-28
FR2827860B1 (fr) 2004-12-10
BR0211334A (pt) 2004-09-28
NO20040151L (no) 2004-01-13
NO328234B1 (no) 2010-01-11
ZA200400246B (en) 2006-07-26
DK1256590T3 (da) 2006-06-06
HU0202437D0 (es) 2002-10-28
FR2827860A1 (fr) 2003-01-31
EA005490B1 (ru) 2005-02-24
PT1256590E (pt) 2006-06-30
SI1256590T1 (sl) 2006-06-30
AU2002334027B8 (en) 2007-01-25
HU229396B1 (hu) 2013-11-28
ES2259071T3 (es) 2006-09-16
PL355159A1 (en) 2003-01-13
ATE318838T1 (de) 2006-03-15
CA2455706C (fr) 2012-01-24
WO2003016336A1 (fr) 2003-02-27
KR100607556B1 (ko) 2006-08-02
DE60209458T2 (de) 2006-10-12
AR035081A1 (es) 2004-04-14
CN1533398A (zh) 2004-09-29
EA200400110A1 (ru) 2004-06-24
DE60209458D1 (de) 2006-04-27
KR20040023673A (ko) 2004-03-18
JP2005500386A (ja) 2005-01-06
US7060842B2 (en) 2006-06-13
EP1256590A1 (fr) 2002-11-13
PL212408B1 (pl) 2012-09-28
US20040198988A1 (en) 2004-10-07
JP3868957B2 (ja) 2007-01-17
MA27130A1 (fr) 2005-01-03
AU2002334027A1 (en) 2003-03-03
AU2002334027B2 (en) 2006-12-14
HUP0202437A2 (hu) 2003-02-28
NZ530427A (en) 2005-08-26
CA2455706A1 (fr) 2003-02-27
EP1256590B1 (fr) 2006-03-01

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