MXPA02009706A - Metodo para sintesis de perindopril y sus sales farmaceuticamente aceptables. - Google Patents

Metodo para sintesis de perindopril y sus sales farmaceuticamente aceptables.

Info

Publication number
MXPA02009706A
MXPA02009706A MXPA02009706A MXPA02009706A MXPA02009706A MX PA02009706 A MXPA02009706 A MX PA02009706A MX PA02009706 A MXPA02009706 A MX PA02009706A MX PA02009706 A MXPA02009706 A MX PA02009706A MX PA02009706 A MXPA02009706 A MX PA02009706A
Authority
MX
Mexico
Prior art keywords
perindopril
synthesis
pharmaceutically acceptable
acceptable salts
formula
Prior art date
Application number
MXPA02009706A
Other languages
English (en)
Inventor
Hugues Turbe
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8848925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA02009706(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of MXPA02009706A publication Critical patent/MXPA02009706A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere a un metodo para la sintesis de perindopril de la formula (I) y sus sales farmaceuticamente aceptables.
MXPA02009706A 2000-04-06 2001-04-05 Metodo para sintesis de perindopril y sus sales farmaceuticamente aceptables. MXPA02009706A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004379A FR2807431B1 (fr) 2000-04-06 2000-04-06 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2001/001026 WO2001058868A1 (fr) 2000-04-06 2001-04-05 Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
MXPA02009706A true MXPA02009706A (es) 2004-09-06

Family

ID=8848925

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02009706A MXPA02009706A (es) 2000-04-06 2001-04-05 Metodo para sintesis de perindopril y sus sales farmaceuticamente aceptables.

Country Status (35)

Country Link
US (1) US6835843B2 (es)
EP (1) EP1268424B1 (es)
JP (1) JP3939553B2 (es)
KR (1) KR100507616B1 (es)
CN (1) CN1296355C (es)
AP (1) AP1385A (es)
AT (1) ATE369338T1 (es)
AU (2) AU4847001A (es)
BG (1) BG65984B1 (es)
BR (1) BRPI0109836B1 (es)
CA (1) CA2405486C (es)
CY (1) CY1108522T1 (es)
CZ (1) CZ302575B6 (es)
DE (1) DE60129800T2 (es)
DK (1) DK1268424T3 (es)
EA (1) EA005079B1 (es)
EE (1) EE05032B1 (es)
ES (1) ES2291307T3 (es)
FR (1) FR2807431B1 (es)
GE (1) GEP20063797B (es)
HK (1) HK1053309A1 (es)
HR (1) HRP20020876B1 (es)
HU (1) HU227674B1 (es)
ME (1) ME00441B (es)
MX (1) MXPA02009706A (es)
NO (1) NO324174B1 (es)
NZ (1) NZ521454A (es)
OA (1) OA12242A (es)
PL (1) PL204471B1 (es)
PT (1) PT1268424E (es)
RS (1) RS50808B (es)
SK (1) SK286921B6 (es)
UA (1) UA75070C2 (es)
WO (1) WO2001058868A1 (es)
ZA (1) ZA200207419B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ES2289060T3 (es) * 2002-01-30 2008-02-01 Les Laboratoires Servier Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis.
JP2005256847A (ja) * 2002-02-28 2005-09-22 Nsk Ltd 車輪用軸受ユニット
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
SI1403277T1 (sl) * 2003-02-28 2005-12-31 Servier Lab NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-((S)-ALANIL)-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA PRI SINTEZI PERINDOPRILA
SI1403275T1 (sl) * 2003-02-28 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
EP1338591B1 (fr) * 2003-02-28 2005-10-26 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
DK1603558T3 (da) 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf
DK1321471T3 (da) * 2003-03-12 2005-08-29 Servier Lab Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
DK1319668T3 (da) * 2003-03-12 2005-02-14 Servier Lab Fremgangsmåde til syntese af (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese af perindopril
PT1323729E (pt) * 2003-03-12 2005-02-28 Servier Lab Novo processo de sintese do acido (2s,3as, 7as)-per-hidroindole-2-carboxilico e os seus esteres e aplicacao a sintese do perindopril
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
CN100395235C (zh) 2003-06-24 2008-06-18 瑟维尔实验室 培哚普利特丁胺的新晶形
PT1367063E (pt) * 2003-07-31 2006-12-29 Servier Lab Novo processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis
ATE338058T1 (de) * 2003-07-31 2006-09-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
DE60330603D1 (de) * 2003-10-21 2010-01-28 Servier Lab Verfahren zur herstellung kristallinem perindopril erbumin
EP1420029B9 (fr) * 2003-12-10 2008-11-12 Les Laboratoires Servier Procédé de synthèse du perindopril et ses sels pharmaceutiquement acceptables
WO2005094793A1 (en) * 2004-03-29 2005-10-13 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing a solid pharmaceutical composition
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
ES2314583T4 (es) * 2005-01-06 2009-05-18 Ipca Laboratories Limited Proceso para sintesis de los derivados del acido (2s,3as,7as)-1-(s)-alanil-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindropil.
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
DE102005058166A1 (de) * 2005-12-05 2007-06-06 Hexal Ag Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren
WO2007085933A2 (en) * 2006-01-25 2007-08-02 Glenmark Pharmaceuticals Limited Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
EP2137148A1 (en) * 2007-03-22 2009-12-30 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
FR2961105B1 (fr) * 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
WO2014057404A1 (en) * 2012-10-10 2014-04-17 Piramal Enterprises Limited An improved process for preparation of perindopril intermediate
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
HRP20020876B1 (en) 2010-10-31
KR20030013381A (ko) 2003-02-14
ES2291307T3 (es) 2008-03-01
ZA200207419B (en) 2003-09-16
EE05032B1 (et) 2008-06-16
DE60129800D1 (de) 2007-09-20
BG65984B1 (bg) 2010-08-31
BG107249A (bg) 2003-07-31
JP2003531825A (ja) 2003-10-28
NO324174B1 (no) 2007-09-03
BRPI0109836B1 (pt) 2015-08-04
HU0101336D0 (en) 2001-06-28
YU73802A (sh) 2006-01-16
HU227674B1 (hu) 2011-11-28
CN1420867A (zh) 2003-05-28
JP3939553B2 (ja) 2007-07-04
EE200200575A (et) 2004-04-15
SK286921B6 (sk) 2009-07-06
PT1268424E (pt) 2007-10-16
CA2405486A1 (fr) 2001-08-16
FR2807431B1 (fr) 2002-07-19
AU2001248470B2 (en) 2005-01-20
ATE369338T1 (de) 2007-08-15
NO20024808D0 (no) 2002-10-04
EA005079B1 (ru) 2004-10-28
AP1385A (en) 2005-04-08
DE60129800T2 (de) 2008-06-05
EP1268424B1 (fr) 2007-08-08
FR2807431A1 (fr) 2001-10-12
HK1053309A1 (en) 2003-10-17
PL346555A1 (en) 2001-09-10
HUP0101336A2 (hu) 2002-02-28
AU4847001A (en) 2001-08-20
CZ302575B6 (cs) 2011-07-20
KR100507616B1 (ko) 2005-08-10
ME00441B (me) 2011-10-10
GEP20063797B (en) 2006-04-25
US20030069431A1 (en) 2003-04-10
DK1268424T3 (da) 2007-12-17
UA75070C2 (uk) 2006-03-15
BR0109836A (pt) 2003-06-24
NO20024808L (no) 2002-10-04
NZ521454A (en) 2004-03-26
SK14182002A3 (sk) 2003-02-04
RS50808B (sr) 2010-08-31
US6835843B2 (en) 2004-12-28
HUP0101336A3 (en) 2003-03-28
CZ20023291A3 (cs) 2003-02-12
CY1108522T1 (el) 2014-04-09
AP2002002630A0 (en) 2002-09-30
EA200201057A1 (ru) 2003-06-26
HRP20020876A2 (en) 2004-02-29
PL204471B1 (pl) 2010-01-29
CN1296355C (zh) 2007-01-24
EP1268424A1 (fr) 2003-01-02
WO2001058868A1 (fr) 2001-08-16
OA12242A (en) 2003-12-08
CA2405486C (fr) 2008-07-29

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