DK1321471T3 - Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf - Google Patents

Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf

Info

Publication number
DK1321471T3
DK1321471T3 DK03290605T DK03290605T DK1321471T3 DK 1321471 T3 DK1321471 T3 DK 1321471T3 DK 03290605 T DK03290605 T DK 03290605T DK 03290605 T DK03290605 T DK 03290605T DK 1321471 T3 DK1321471 T3 DK 1321471T3
Authority
DK
Denmark
Prior art keywords
perindopril
pharmaceutically acceptable
acceptable salts
synthesis procedure
new synthesis
Prior art date
Application number
DK03290605T
Other languages
English (en)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1321471T3 publication Critical patent/DK1321471T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK03290605T 2003-03-12 2003-03-12 Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf DK1321471T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290605A EP1321471B1 (fr) 2003-03-12 2003-03-12 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
DK1321471T3 true DK1321471T3 (da) 2005-08-29

Family

ID=8185877

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03290605T DK1321471T3 (da) 2003-03-12 2003-03-12 Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf

Country Status (10)

Country Link
EP (1) EP1321471B1 (da)
AR (1) AR043567A1 (da)
AT (1) ATE294814T1 (da)
DE (1) DE60300581T2 (da)
DK (1) DK1321471T3 (da)
ES (1) ES2240919T3 (da)
MY (1) MY135359A (da)
PT (1) PT1321471E (da)
SI (1) SI1321471T1 (da)
WO (1) WO2004083238A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE315043T1 (de) 2003-06-30 2006-02-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
PT1362864E (pt) * 2003-06-30 2007-07-23 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico
DK1367062T3 (da) * 2003-07-31 2007-01-02 Servier Lab Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ES2272922T3 (es) * 2003-08-29 2007-05-01 Les Laboratoires Servier Nuevo procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
SI1380591T1 (sl) 2003-08-29 2006-02-28 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
UA92613C2 (ru) * 2005-08-12 2010-11-25 Лек Фармасьютиклз Д.Д. Способ получения кристаллической формы d эрбумина периндоприла
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
DE60300581T2 (de) 2006-01-19
AR043567A1 (es) 2005-08-03
ES2240919T3 (es) 2005-10-16
DE60300581D1 (de) 2005-06-09
WO2004083238A1 (fr) 2004-09-30
ATE294814T1 (de) 2005-05-15
PT1321471E (pt) 2005-07-29
EP1321471A1 (fr) 2003-06-25
SI1321471T1 (da) 2005-08-31
MY135359A (en) 2008-03-31
EP1321471B1 (fr) 2005-05-04

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