DE60330603D1 - Verfahren zur herstellung kristallinem perindopril erbumin - Google Patents
Verfahren zur herstellung kristallinem perindopril erbuminInfo
- Publication number
- DE60330603D1 DE60330603D1 DE60330603T DE60330603T DE60330603D1 DE 60330603 D1 DE60330603 D1 DE 60330603D1 DE 60330603 T DE60330603 T DE 60330603T DE 60330603 T DE60330603 T DE 60330603T DE 60330603 D1 DE60330603 D1 DE 60330603D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- lower aliphatic
- preparing crystalline
- crystalline perindopril
- perindopril
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960002582 perindopril Drugs 0.000 title abstract 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- -1 dimethyl acetals Chemical class 0.000 abstract 3
- 238000001816 cooling Methods 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229960003929 perindopril erbumine Drugs 0.000 abstract 1
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical compound CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2003/000340 WO2005037788A1 (en) | 2003-10-21 | 2003-10-21 | Novel method for preparation of crystalline perindopril erbumine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60330603D1 true DE60330603D1 (de) | 2010-01-28 |
Family
ID=34452214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60330603T Expired - Lifetime DE60330603D1 (de) | 2003-10-21 | 2003-10-21 | Verfahren zur herstellung kristallinem perindopril erbumin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7456296B2 (de) |
| EP (1) | EP1675827B1 (de) |
| JP (1) | JP4677611B2 (de) |
| AT (1) | ATE452124T1 (de) |
| AU (1) | AU2003300689B2 (de) |
| BR (1) | BR0318561A (de) |
| CY (1) | CY1110608T1 (de) |
| DE (1) | DE60330603D1 (de) |
| DK (1) | DK1675827T3 (de) |
| ES (1) | ES2336554T3 (de) |
| IL (1) | IL174860A (de) |
| PT (1) | PT1675827E (de) |
| SI (1) | SI1675827T1 (de) |
| WO (1) | WO2005037788A1 (de) |
| ZA (1) | ZA200604068B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005108365A1 (en) * | 2004-05-07 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Processes for the preparation of alpha polymorph of perindopril erbumine |
| SG125976A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
| SG125975A1 (en) * | 2005-03-11 | 2006-10-30 | Servier Lab | New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it |
| WO2007017894A2 (en) * | 2005-05-05 | 2007-02-15 | Arch Pharmalabs Limited | PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE |
| AU2006281681A1 (en) * | 2005-08-12 | 2007-02-22 | Sandoz Ag | New crystalline form of perindopril erbumine |
| BRPI0615607A2 (pt) * | 2005-08-30 | 2011-05-24 | Lek Pharmaceuticals | composição farmacêutica compreendendo perindopril ou seus sais |
| EA200600630A1 (ru) * | 2006-04-20 | 2007-02-27 | ИСМАГИЛОВ, Искандар Халиуллович | ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА |
| WO2008050185A2 (en) * | 2006-10-26 | 2008-05-02 | Glenmark Pharmaceuticals Limited | Novel polymorphs of perindopril erbumine |
| EP1964836A3 (de) * | 2006-11-06 | 2008-11-19 | IPCA Laboratories Limited | Verfahren für die Zubereitung von Perindopril-Erbumin in alpha-kristalliner Form |
| GB0624090D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amine salts |
| EP2137148A1 (de) * | 2007-03-22 | 2009-12-30 | Aarti Healthcare Limited | Verfahren zur herstellung von perindoprilerbuminsalz und neuer polymorph (s) davon |
| AU2013201812B2 (en) * | 2007-06-27 | 2015-04-02 | Les Laboratoires Servier | Salts of perindopril |
| SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
| PT105315B (pt) | 2010-09-29 | 2013-01-16 | Inst Superior Tecnico | Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas |
| JP5776888B2 (ja) * | 2011-05-25 | 2015-09-09 | 日産自動車株式会社 | 電気デバイス用負極活物質 |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| CN107098949B (zh) * | 2017-04-20 | 2021-03-16 | 上药东英（江苏）药业有限公司 | 一种制备培哚普利叔丁胺盐的绿色合成新工艺 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
| FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811319B1 (fr) | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| FR2811320B1 (fr) | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
| AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| ES2289060T3 (es) * | 2002-01-30 | 2008-02-01 | Les Laboratoires Servier | Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis. |
| EP1371659B1 (de) * | 2003-08-29 | 2005-10-12 | Les Laboratoires Servier | Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen |
-
2003
- 2003-10-21 AU AU2003300689A patent/AU2003300689B2/en not_active Ceased
- 2003-10-21 EP EP03818870A patent/EP1675827B1/de not_active Expired - Lifetime
- 2003-10-21 AT AT03818870T patent/ATE452124T1/de active
- 2003-10-21 DE DE60330603T patent/DE60330603D1/de not_active Expired - Lifetime
- 2003-10-21 ES ES03818870T patent/ES2336554T3/es not_active Expired - Lifetime
- 2003-10-21 DK DK03818870.2T patent/DK1675827T3/da active
- 2003-10-21 JP JP2005509586A patent/JP4677611B2/ja not_active Expired - Fee Related
- 2003-10-21 PT PT03818870T patent/PT1675827E/pt unknown
- 2003-10-21 SI SI200331760T patent/SI1675827T1/sl unknown
- 2003-10-21 US US10/576,386 patent/US7456296B2/en not_active Expired - Fee Related
- 2003-10-21 BR BRPI0318561-3A patent/BR0318561A/pt active Search and Examination
- 2003-10-21 WO PCT/IN2003/000340 patent/WO2005037788A1/en active Application Filing
-
2006
- 2006-04-06 IL IL174860A patent/IL174860A/en active IP Right Grant
- 2006-05-19 ZA ZA2006/04068A patent/ZA200604068B/en unknown
-
2010
- 2010-01-21 CY CY20101100064T patent/CY1110608T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE452124T1 (de) | 2010-01-15 |
| EP1675827A1 (de) | 2006-07-05 |
| DK1675827T3 (da) | 2010-04-19 |
| CY1110608T1 (el) | 2015-04-29 |
| ES2336554T3 (es) | 2010-04-14 |
| BR0318561A (pt) | 2006-10-10 |
| WO2005037788A1 (en) | 2005-04-28 |
| AU2003300689B2 (en) | 2009-01-29 |
| SI1675827T1 (sl) | 2010-04-30 |
| AU2003300689A1 (en) | 2005-05-05 |
| EP1675827B1 (de) | 2009-12-16 |
| IL174860A0 (en) | 2006-08-20 |
| US20070149604A1 (en) | 2007-06-28 |
| IL174860A (en) | 2011-09-27 |
| JP4677611B2 (ja) | 2011-04-27 |
| JP2007518668A (ja) | 2007-07-12 |
| ZA200604068B (en) | 2008-01-08 |
| PT1675827E (pt) | 2010-02-15 |
| US7456296B2 (en) | 2008-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |