EA200400110A1 - НОВЫЙ СПОСОБ СИНТЕЗА СОЕДИНЕНИЙ (2S, 3aS, 7aS )-1-[(S)-АЛАНИЛ]-ОКТАГИДРО-1H-ИНДОЛ-2-КАРБОНОВОЙ КИСЛОТЫ И ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА - Google Patents

НОВЫЙ СПОСОБ СИНТЕЗА СОЕДИНЕНИЙ (2S, 3aS, 7aS )-1-[(S)-АЛАНИЛ]-ОКТАГИДРО-1H-ИНДОЛ-2-КАРБОНОВОЙ КИСЛОТЫ И ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА

Info

Publication number
EA200400110A1
EA200400110A1 EA200400110A EA200400110A EA200400110A1 EA 200400110 A1 EA200400110 A1 EA 200400110A1 EA 200400110 A EA200400110 A EA 200400110A EA 200400110 A EA200400110 A EA 200400110A EA 200400110 A1 EA200400110 A1 EA 200400110A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
compounds
perindopril
octagidro
alanyl
Prior art date
Application number
EA200400110A
Other languages
English (en)
Other versions
EA005490B1 (ru
Inventor
Тибор Мезей
Марта Порч-Маккаи
Дьюла Шимиг
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200400110(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200400110A1 publication Critical patent/EA200400110A1/ru
Publication of EA005490B1 publication Critical patent/EA005490B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Способ промышленного синтеза соединений формулы (I)в которой Rпредставляет собой атом водорода или алкильную или бензильную группу и Rпредставляет собой группу, которая защищает аминофункцию. Применение в синтезе периндоприла и его фармацевтически приемлемых солей.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400110A 2001-07-24 2002-07-23 НОВЫЙ СПОСОБ СИНТЕЗА СОЕДИНЕНИЙ (2S, 3aS, 7aS)-1-[(S)-АЛАНИЛ]ОКТАГИДРО -1H-ИНДОЛ-2-КАРБОНОВОЙ КИСЛОТЫ И ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА EA005490B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109839A FR2827860B1 (fr) 2001-07-24 2001-07-24 Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
PCT/FR2002/002627 WO2003016336A1 (fr) 2001-07-24 2002-07-23 NOUVEAU PROCEDE DE SYNTHESE DE DERIVES DE L'ACIDE (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIQUE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL

Publications (2)

Publication Number Publication Date
EA200400110A1 true EA200400110A1 (ru) 2004-06-24
EA005490B1 EA005490B1 (ru) 2005-02-24

Family

ID=8865826

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400110A EA005490B1 (ru) 2001-07-24 2002-07-23 НОВЫЙ СПОСОБ СИНТЕЗА СОЕДИНЕНИЙ (2S, 3aS, 7aS)-1-[(S)-АЛАНИЛ]ОКТАГИДРО -1H-ИНДОЛ-2-КАРБОНОВОЙ КИСЛОТЫ И ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА

Country Status (25)

Country Link
US (1) US7060842B2 (ru)
EP (1) EP1256590B1 (ru)
JP (1) JP3868957B2 (ru)
KR (1) KR100607556B1 (ru)
CN (1) CN1533398A (ru)
AR (1) AR035081A1 (ru)
AT (1) ATE318838T1 (ru)
AU (1) AU2002334027B8 (ru)
BR (1) BR0211334A (ru)
CA (1) CA2455706C (ru)
DE (1) DE60209458T2 (ru)
DK (1) DK1256590T3 (ru)
EA (1) EA005490B1 (ru)
ES (1) ES2259071T3 (ru)
FR (1) FR2827860B1 (ru)
HU (1) HU229396B1 (ru)
MA (1) MA27130A1 (ru)
MX (1) MXPA04000443A (ru)
NO (1) NO328234B1 (ru)
NZ (1) NZ530427A (ru)
PL (1) PL212408B1 (ru)
PT (1) PT1256590E (ru)
SI (1) SI1256590T1 (ru)
WO (1) WO2003016336A1 (ru)
ZA (1) ZA200400246B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1333026B1 (en) * 2002-01-30 2007-06-27 Les Laboratoires Servier Process for the preparation of high purity perindopril and intermediates useful in the synthesis
DE60301930T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
SI1403277T1 (sl) * 2003-02-28 2005-12-31 Servier Lab NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-((S)-ALANIL)-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA PRI SINTEZI PERINDOPRILA
SI1338591T1 (sl) * 2003-02-28 2006-02-28 Servier Lab NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA
WO2004075889A1 (en) 2003-02-28 2004-09-10 Lupin Limited Process for preparation of perindopril and salts thereof
ES2240919T3 (es) * 2003-03-12 2005-10-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1323729T3 (da) * 2003-03-12 2005-02-14 Servier Lab Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril
SI1319668T1 (en) * 2003-03-12 2005-02-28 Les Laboratoires Servier Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
EA008603B1 (ru) 2003-06-24 2007-06-29 Ле Лаборатуар Сервье Новые кристаллические формы периндоприл эрбумина
EP1367063B1 (fr) * 2003-07-31 2006-08-23 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
JP4720132B2 (ja) * 2003-10-30 2011-07-13 住友化学株式会社 光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko) 2006-12-19 2013-11-15 에스케이바이오팜 주식회사 옥타하이드로인돌-2-카르복시산의 제조방법
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
DE60209458D1 (de) 2006-04-27
DK1256590T3 (da) 2006-06-06
AU2002334027A1 (en) 2003-03-03
FR2827860A1 (fr) 2003-01-31
AU2002334027B2 (en) 2006-12-14
PT1256590E (pt) 2006-06-30
HU0202437D0 (ru) 2002-10-28
AR035081A1 (es) 2004-04-14
NO328234B1 (no) 2010-01-11
EA005490B1 (ru) 2005-02-24
CA2455706C (fr) 2012-01-24
SI1256590T1 (sl) 2006-06-30
PL355159A1 (en) 2003-01-13
HUP0202437A3 (en) 2003-05-28
WO2003016336A1 (fr) 2003-02-27
BR0211334A (pt) 2004-09-28
PL212408B1 (pl) 2012-09-28
DE60209458T2 (de) 2006-10-12
KR100607556B1 (ko) 2006-08-02
US7060842B2 (en) 2006-06-13
JP2005500386A (ja) 2005-01-06
EP1256590B1 (fr) 2006-03-01
NO20040151L (no) 2004-01-13
CN1533398A (zh) 2004-09-29
AU2002334027B8 (en) 2007-01-25
ATE318838T1 (de) 2006-03-15
MXPA04000443A (es) 2004-03-18
EP1256590A1 (fr) 2002-11-13
JP3868957B2 (ja) 2007-01-17
US20040198988A1 (en) 2004-10-07
FR2827860B1 (fr) 2004-12-10
HUP0202437A2 (hu) 2003-02-28
KR20040023673A (ko) 2004-03-18
NZ530427A (en) 2005-08-26
CA2455706A1 (fr) 2003-02-27
ZA200400246B (en) 2006-07-26
HU229396B1 (hu) 2013-11-28
MA27130A1 (fr) 2005-01-03
ES2259071T3 (es) 2006-09-16

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU