EA199900581A1 - Производные индана или дигидроиндола - Google Patents
Производные индана или дигидроиндолаInfo
- Publication number
- EA199900581A1 EA199900581A1 EA199900581A EA199900581A EA199900581A1 EA 199900581 A1 EA199900581 A1 EA 199900581A1 EA 199900581 A EA199900581 A EA 199900581A EA 199900581 A EA199900581 A EA 199900581A EA 199900581 A1 EA199900581 A1 EA 199900581A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dihydroindola
- indana
- derivatives
- compounds
- dihydroindole
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical compound C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C5/00—Details of stores covered by group G11C11/00
- G11C5/02—Disposition of storage elements, e.g. in the form of a matrix array
- G11C5/025—Geometric lay-out considerations of storage- and peripheral-blocks in a semiconductor storage device
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
- G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
- G11C7/1048—Data bus control circuits, e.g. precharging, presetting, equalising
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Настоящее изобретение относится к замещенным соединениям индана или дигидроиндола формулы (I), в которой А обозначает индол. Эти соединения обладают высокой аффинностью по отношению к рецепторам D.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK151496 | 1996-12-20 | ||
PCT/DK1997/000587 WO1998028293A1 (en) | 1996-12-20 | 1997-12-19 | Indane or dihydroindole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199900581A1 true EA199900581A1 (ru) | 2000-04-24 |
EA002158B1 EA002158B1 (ru) | 2001-12-24 |
Family
ID=8105631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900581A EA002158B1 (ru) | 1996-12-20 | 1997-12-19 | Производные индана или дигидроиндола |
Country Status (28)
Country | Link |
---|---|
US (3) | US6262087B1 (ru) |
EP (1) | EP0946542B1 (ru) |
JP (1) | JP3251300B2 (ru) |
KR (1) | KR100432297B1 (ru) |
CN (3) | CN1244558C (ru) |
AR (1) | AR008545A1 (ru) |
AT (1) | ATE225784T1 (ru) |
AU (1) | AU731243B2 (ru) |
BG (1) | BG63968B1 (ru) |
BR (1) | BR9714039A (ru) |
CZ (1) | CZ297416B6 (ru) |
DE (1) | DE69716296T2 (ru) |
DK (1) | DK0946542T3 (ru) |
EA (1) | EA002158B1 (ru) |
ES (1) | ES2185058T3 (ru) |
HK (1) | HK1025775A1 (ru) |
HU (1) | HUP0000079A3 (ru) |
IL (1) | IL130133A (ru) |
IS (1) | IS2018B (ru) |
NO (2) | NO318978B1 (ru) |
NZ (1) | NZ335973A (ru) |
PL (1) | PL188418B1 (ru) |
PT (1) | PT946542E (ru) |
SK (1) | SK283678B6 (ru) |
TR (1) | TR199901407T2 (ru) |
UA (1) | UA66778C2 (ru) |
WO (1) | WO1998028293A1 (ru) |
ZA (1) | ZA9711376B (ru) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
TWI242011B (en) | 1997-03-31 | 2005-10-21 | Eisai Co Ltd | 1,4-substituted cyclic amine derivatives |
US6150533A (en) * | 1998-04-08 | 2000-11-21 | American Home Products Corp. | N-aryloxyethyl-indoly-alkylamines for the treatment of depression |
ES2188155T3 (es) * | 1998-04-08 | 2003-06-16 | Wyeth Corp | N-ariloxietilindolilalquilaminas para el tratamiento de la depresion. |
TW528754B (en) * | 1998-04-29 | 2003-04-21 | Wyeth Corp | Indolyl derivatibes as serotonergic agents |
US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
EP1085890A1 (en) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Novel sodium channel drugs and uses |
US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
AU4425399A (en) * | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Novel therapeutic agents that modulate 5-ht receptors |
CA2335711A1 (en) * | 1998-06-19 | 1999-12-29 | Ivan Mikkelsen | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
ID27976A (id) | 1998-06-19 | 2001-05-03 | Lundbeck & Co As H | 4,5,6 dan 7-indol dan turunan-turunan indolin, pembuatan dan penggunaannya |
AR020773A1 (es) | 1998-10-16 | 2002-05-29 | Duphar Int Res | Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto |
TR200101796T2 (tr) | 1998-12-23 | 2001-11-21 | H. Lundbeck A/S | 5-Siyanofitalitin preparasyonuna yönelik metot |
ATE237604T1 (de) | 1999-04-14 | 2003-05-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
WO2000069424A2 (en) * | 1999-05-12 | 2000-11-23 | Solvay Pharmaceuticals B.V. | Method of treating psychotic disorders |
WO2000076967A1 (en) * | 1999-06-14 | 2000-12-21 | Neurogen Corporation | Benzylpiperazinyl-indolinylethanones |
US6355644B1 (en) | 1999-06-14 | 2002-03-12 | Neurogen Corporation | Benzylpiperazinyl-indolinylethanones |
CA2341542A1 (en) * | 1999-06-24 | 2000-12-28 | Toray Industries, Inc. | .alpha.1b-adrenergic receptor antagonists |
PL201178B1 (pl) | 1999-08-23 | 2009-03-31 | Solvay Pharm Bv | Nowe pochodne fenylopiperazyny, sposób ich wytwarzania, kompozycja farmaceutyczna oraz zastosowanie |
WO2001043740A1 (en) | 1999-12-17 | 2001-06-21 | Bristol-Myers Squibb Company | Antipsychotic heterocycle compounds |
CN100415737C (zh) * | 2000-06-14 | 2008-09-03 | H·隆德贝克有限公司 | 用于治疗cns疾病的吲哚衍生物 |
DK1294710T3 (da) * | 2000-06-14 | 2005-10-03 | Lundbeck & Co As H | Indolderivater, der er egnede til behandlingen af CNS-lidelser |
AR028685A1 (es) * | 2000-06-14 | 2003-05-21 | Lundbeck & Co As H | Derivados de indol |
CA2414115A1 (en) * | 2000-06-29 | 2002-01-03 | Jakob Felding | Indole derivatives useful for the treatment of cns disorders |
CA2354880C (en) | 2000-08-18 | 2003-06-03 | H. Lundbeck A/S | Method for the preparation of citalopram |
AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
AR033287A1 (es) * | 2001-05-09 | 2003-12-10 | Lundbeck & Co As H | Tratamiento del adhd |
WO2003080050A1 (en) * | 2002-03-27 | 2003-10-02 | H. Lundbeck A/S | The use of 3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition |
WO2003102097A1 (en) * | 2002-05-31 | 2003-12-11 | H. Lundbeck A/S | The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole |
AU2003243930A1 (en) * | 2002-07-05 | 2004-01-23 | H. Lundbeck A/S | Pharmaceutical composition comprising (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole |
AU2003257407A1 (en) * | 2002-08-29 | 2004-03-19 | H. Lundbeck A/S | S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
WO2004080407A2 (en) * | 2003-03-07 | 2004-09-23 | Predix Pharmaceuticals Holdings, Inc. | New serotonin modulating compounds and uses therefor |
KR20070011552A (ko) * | 2004-05-11 | 2007-01-24 | 에지스 지오기스제르기아르 엔와이알티. | 5-ht7 수용체 활성제로서 알킬 옥스인돌의 피리딘유도체 |
CA2580020A1 (en) * | 2004-09-09 | 2006-03-23 | Ian M. Bell | Aryl spirolactam cgrp receptor antagonists |
DE602005016836D1 (de) * | 2004-11-26 | 2009-11-05 | Janssen Pharmaceutica Nv | Chotischer und anxiolytischer aktivität |
US7544685B2 (en) | 2005-08-17 | 2009-06-09 | H. Lundbeck A/S | 2,3-dihydroindole compounds |
AR057748A1 (es) * | 2005-08-17 | 2007-12-12 | Lundbeck & Co As H | Derivados de 2,3 dihidroindol. composiciones farmaceuticas |
JP2009515833A (ja) * | 2005-10-24 | 2009-04-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 3−ピペリジン−4−イル−インドールorl−1受容体モジュレーター |
WO2008015516A1 (en) * | 2006-07-28 | 2008-02-07 | Pfizer Products Inc. | Fused tricyclic heterocycles for the treatment of schizophrenia |
KR20090083479A (ko) * | 2006-11-28 | 2009-08-03 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체 |
PL395469A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
US9963458B2 (en) | 2012-12-27 | 2018-05-08 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
EP3866927A4 (en) * | 2018-10-17 | 2022-07-27 | Nikang Therapeutics, Inc. | INDANE DERIVATIVES USED AS HYPOXIA INDUCTIBLE (ALPHA) FACTOR 2 INHIBITORS |
GB201919213D0 (en) * | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3875073T2 (de) * | 1987-11-20 | 1993-03-11 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
FR2654104B1 (fr) | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
TW199152B (ru) | 1990-11-01 | 1993-02-01 | Takeda Pharm Industry Co Ltd | |
FR2670491B1 (fr) | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
WO1994021627A1 (en) * | 1993-03-18 | 1994-09-29 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
GB9305641D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
DE4414113A1 (de) | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
AU694212B2 (en) | 1994-04-28 | 1998-07-16 | Merck Sharp & Dohme Limited | Benzofuran derivatives as d4 receptor antagonists |
ZA954689B (en) * | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
CA2335711A1 (en) * | 1998-06-19 | 1999-12-29 | Ivan Mikkelsen | 4,5,6 and 7-indole and indoline derivatives, their preparation and use |
-
1997
- 1997-12-18 ZA ZA9711376A patent/ZA9711376B/xx unknown
- 1997-12-19 CZ CZ0222799A patent/CZ297416B6/cs not_active IP Right Cessation
- 1997-12-19 DK DK97949998T patent/DK0946542T3/da active
- 1997-12-19 CN CNB031088511A patent/CN1244558C/zh not_active Expired - Fee Related
- 1997-12-19 HU HU0000079A patent/HUP0000079A3/hu unknown
- 1997-12-19 EA EA199900581A patent/EA002158B1/ru not_active IP Right Cessation
- 1997-12-19 PL PL97334011A patent/PL188418B1/pl not_active IP Right Cessation
- 1997-12-19 EP EP97949998A patent/EP0946542B1/en not_active Expired - Lifetime
- 1997-12-19 IL IL13013397A patent/IL130133A/xx not_active IP Right Cessation
- 1997-12-19 SK SK813-99A patent/SK283678B6/sk not_active IP Right Cessation
- 1997-12-19 AU AU53109/98A patent/AU731243B2/en not_active Ceased
- 1997-12-19 CN CNB031088503A patent/CN1282644C/zh not_active Expired - Fee Related
- 1997-12-19 DE DE69716296T patent/DE69716296T2/de not_active Expired - Fee Related
- 1997-12-19 US US09/331,560 patent/US6262087B1/en not_active Expired - Fee Related
- 1997-12-19 CN CNB971818134A patent/CN1146556C/zh not_active Expired - Fee Related
- 1997-12-19 PT PT97949998T patent/PT946542E/pt unknown
- 1997-12-19 KR KR10-1999-7005622A patent/KR100432297B1/ko not_active IP Right Cessation
- 1997-12-19 TR TR1999/01407T patent/TR199901407T2/xx unknown
- 1997-12-19 UA UA99074138A patent/UA66778C2/ru unknown
- 1997-12-19 JP JP52826298A patent/JP3251300B2/ja not_active Expired - Fee Related
- 1997-12-19 AR ARP970106065A patent/AR008545A1/es active IP Right Grant
- 1997-12-19 NZ NZ335973A patent/NZ335973A/xx unknown
- 1997-12-19 BR BR9714039-2A patent/BR9714039A/pt not_active Application Discontinuation
- 1997-12-19 ES ES97949998T patent/ES2185058T3/es not_active Expired - Lifetime
- 1997-12-19 AT AT97949998T patent/ATE225784T1/de not_active IP Right Cessation
- 1997-12-19 WO PCT/DK1997/000587 patent/WO1998028293A1/en active IP Right Grant
-
1999
- 1999-05-28 IS IS5061A patent/IS2018B/is unknown
- 1999-06-14 NO NO19992895A patent/NO318978B1/no not_active IP Right Cessation
- 1999-07-07 BG BG103561A patent/BG63968B1/bg unknown
-
2000
- 2000-08-11 HK HK00105032A patent/HK1025775A1/xx not_active IP Right Cessation
-
2001
- 2001-03-21 US US09/813,480 patent/US6552044B2/en not_active Expired - Fee Related
- 2001-03-21 US US09/814,037 patent/US6352988B2/en not_active Expired - Fee Related
-
2004
- 2004-10-21 NO NO20044514A patent/NO20044514L/no not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA199900581A1 (ru) | Производные индана или дигидроиндола | |
EA200101177A1 (ru) | Производные индола в качестве антагонистов прогестерона | |
EA199900166A1 (ru) | Замещенные 6,6-гетеробициклические производные | |
EA199700280A1 (ru) | Ингибиторы протеинкиназы с | |
DK0594702T3 (da) | Substituerede indoler som midler mod AIDS | |
EA199900381A1 (ru) | Арил(тио)эфиры галогенпиримидина в качестве пестицидов | |
TR199701146T1 (xx) | N�rotensin resept�rleri �zerinde etkili 1-Fenilpirazol-3-Karboksamidler. | |
EA200000251A1 (ru) | Производные резорцинола | |
ES2138691T3 (es) | Procedimiento para la obtencion de derivados de n-acil-5-fluorocitidina. | |
DK0700380T3 (da) | N-Alkylthiopolyaminderivater som radioprotektive midler | |
EA199900580A1 (ru) | Фармацевтические производные аминофосфоновой кислоты | |
EA200000094A1 (ru) | Способ получения замещенного пергидроизоиндола | |
EA200200732A1 (ru) | Замещенные производные фенилпиперазина, их получение и применение | |
EA199800867A1 (ru) | Соединения тетрагидробетакарболина | |
ES2088011T3 (es) | Antagonistas de aminoacidos excitadores. | |
EA200000910A1 (ru) | Азабициклические лиганды рецепторов 5нт1 | |
EA200100517A1 (ru) | Антагонисты 5ht1 для антидепрессантной терапии | |
EA200100854A1 (ru) | Кальций-литические соединения | |
EA199800753A1 (ru) | Бензотиофены, составы их содержащие и способы с их использованием | |
EA199900235A1 (ru) | Аморфные бензотиофены, способы получения и способы применения | |
EA200000561A1 (ru) | Триазиновые соединения для лечения расстройств цнс | |
EA200200727A1 (ru) | Новые производные индола | |
EA200100051A1 (ru) | Ингибиторы fkbp | |
EA200000522A1 (ru) | 5-htагонисты | |
EA199900241A1 (ru) | ЗАМЕЩЕННЫЕ 1,2,3,4-ТЕТРАГИДРО-2-ДИБЕНЗОФУРАНАМИНЫ И 2-АМИНОЦИКЛОГЕПТА [b] БЕНЗОФУРАНЫ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |