EA199900581A1 - Производные индана или дигидроиндола - Google Patents

Производные индана или дигидроиндола

Info

Publication number
EA199900581A1
EA199900581A1 EA199900581A EA199900581A EA199900581A1 EA 199900581 A1 EA199900581 A1 EA 199900581A1 EA 199900581 A EA199900581 A EA 199900581A EA 199900581 A EA199900581 A EA 199900581A EA 199900581 A1 EA199900581 A1 EA 199900581A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dihydroindola
indana
derivatives
compounds
dihydroindole
Prior art date
Application number
EA199900581A
Other languages
English (en)
Other versions
EA002158B1 (ru
Inventor
Енс Кристиан Перрегор
Бенни Банг-Андерсен
Хенрик Педерсен
Иван Миккельсен
Роберт Дансер
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA199900581A1 publication Critical patent/EA199900581A1/ru
Publication of EA002158B1 publication Critical patent/EA002158B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C5/00—Details of stores covered by group G11C11/00
    • G11C5/02—Disposition of storage elements, e.g. in the form of a matrix array
    • G11C5/025—Geometric lay-out considerations of storage- and peripheral-blocks in a semiconductor storage device
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
    • G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
    • G11C7/1048—Data bus control circuits, e.g. precharging, presetting, equalising

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение относится к замещенным соединениям индана или дигидроиндола формулы (I), в которой А обозначает индол. Эти соединения обладают высокой аффинностью по отношению к рецепторам D.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900581A 1996-12-20 1997-12-19 Производные индана или дигидроиндола EA002158B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK151496 1996-12-20
PCT/DK1997/000587 WO1998028293A1 (en) 1996-12-20 1997-12-19 Indane or dihydroindole derivatives

Publications (2)

Publication Number Publication Date
EA199900581A1 true EA199900581A1 (ru) 2000-04-24
EA002158B1 EA002158B1 (ru) 2001-12-24

Family

ID=8105631

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900581A EA002158B1 (ru) 1996-12-20 1997-12-19 Производные индана или дигидроиндола

Country Status (28)

Country Link
US (3) US6262087B1 (ru)
EP (1) EP0946542B1 (ru)
JP (1) JP3251300B2 (ru)
KR (1) KR100432297B1 (ru)
CN (3) CN1146556C (ru)
AR (1) AR008545A1 (ru)
AT (1) ATE225784T1 (ru)
AU (1) AU731243B2 (ru)
BG (1) BG63968B1 (ru)
BR (1) BR9714039A (ru)
CZ (1) CZ297416B6 (ru)
DE (1) DE69716296T2 (ru)
DK (1) DK0946542T3 (ru)
EA (1) EA002158B1 (ru)
ES (1) ES2185058T3 (ru)
HK (1) HK1025775A1 (ru)
HU (1) HUP0000079A3 (ru)
IL (1) IL130133A (ru)
IS (1) IS2018B (ru)
NO (2) NO318978B1 (ru)
NZ (1) NZ335973A (ru)
PL (1) PL188418B1 (ru)
PT (1) PT946542E (ru)
SK (1) SK283678B6 (ru)
TR (1) TR199901407T2 (ru)
UA (1) UA66778C2 (ru)
WO (1) WO1998028293A1 (ru)
ZA (1) ZA9711376B (ru)

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US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
TW528754B (en) * 1998-04-29 2003-04-21 Wyeth Corp Indolyl derivatibes as serotonergic agents
US6362371B1 (en) * 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
CA2319174A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors
EP1085890A1 (en) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Novel sodium channel drugs and uses
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NZ508506A (en) * 1998-06-19 2004-01-30 H 4,5,6 and 7-indole and indoline derivatives, their preparation and use
AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
DK1173431T4 (da) 1999-04-14 2010-01-04 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
CA2373855A1 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
US6355644B1 (en) 1999-06-14 2002-03-12 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
AU5487300A (en) * 1999-06-14 2001-01-02 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
WO2000078716A1 (fr) * 1999-06-24 2000-12-28 Toray Industries, Inc. ANTAGONISTES DU RECEPTEUR ADRENERGIQUE-α¿1B?
SK287018B6 (sk) 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
EP1242072A4 (en) 1999-12-17 2004-02-04 Bristol Myers Squibb Co ANTIPSYCHOTIC HETEROCYCLIC COMPOUNDS
EA006315B1 (ru) * 2000-06-14 2005-10-27 Х.Лундбекк А/С Производные индола, пригодные для лечения расстройств цнс
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol
EP1468996B1 (en) * 2000-06-14 2007-09-26 H. Lundbeck A/S Indole derivatives for the treatment of CNS disorders
AU2001273882A1 (en) * 2000-06-29 2002-01-08 H. Lundbeck A/S Indole derivatives useful for the treatment of CNS disorders
FI20011622A (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR033287A1 (es) 2001-05-09 2003-12-10 Lundbeck & Co As H Tratamiento del adhd
WO2003080050A1 (en) * 2002-03-27 2003-10-02 H. Lundbeck A/S The use of 3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition
AU2003236207A1 (en) * 2002-05-31 2003-12-19 H. Lundbeck A/S The hydrochloride of (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
WO2004004717A1 (en) * 2002-07-05 2004-01-15 H. Lundbeck A/S Pharmaceutical composition comprising (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole
WO2004020437A1 (en) * 2002-08-29 2004-03-11 H. Lundbeck A/S S-(+)-3-{1-[2-(2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
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AR057748A1 (es) * 2005-08-17 2007-12-12 Lundbeck & Co As H Derivados de 2,3 dihidroindol. composiciones farmaceuticas
US20080015214A1 (en) * 2005-10-24 2008-01-17 Bignan Gilles C 3-piperidin-4-yl-indole orl-1 receptor modulators
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PL395469A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
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Also Published As

Publication number Publication date
ZA9711376B (en) 1998-07-21
DK0946542T3 (da) 2003-02-10
EP0946542A1 (en) 1999-10-06
DE69716296T2 (de) 2003-09-11
BG63968B1 (bg) 2003-08-29
US6262087B1 (en) 2001-07-17
NO318978B1 (no) 2005-05-30
CN1515551A (zh) 2004-07-28
CN1244558C (zh) 2006-03-08
KR20000069621A (ko) 2000-11-25
PT946542E (pt) 2003-02-28
WO1998028293A1 (en) 1998-07-02
US6552044B2 (en) 2003-04-22
HUP0000079A3 (en) 2002-11-28
AU5310998A (en) 1998-07-17
NZ335973A (en) 2000-11-24
CZ222799A3 (cs) 1999-12-15
US20010021777A1 (en) 2001-09-13
ES2185058T3 (es) 2003-04-16
IL130133A (en) 2005-08-31
CN1146556C (zh) 2004-04-21
EA002158B1 (ru) 2001-12-24
TR199901407T2 (xx) 1999-08-23
ATE225784T1 (de) 2002-10-15
NO20044514L (no) 1999-08-13
DE69716296D1 (de) 2002-11-14
EP0946542B1 (en) 2002-10-09
SK81399A3 (en) 1999-12-10
IS2018B (is) 2005-06-15
JP2000513731A (ja) 2000-10-17
SK283678B6 (sk) 2003-11-04
US20010020095A1 (en) 2001-09-06
HUP0000079A2 (hu) 2001-10-28
CN1246117A (zh) 2000-03-01
IL130133A0 (en) 2000-06-01
AR008545A1 (es) 2000-01-19
JP3251300B2 (ja) 2002-01-28
NO992895D0 (no) 1999-06-14
PL334011A1 (en) 2000-01-31
BR9714039A (pt) 2000-05-09
CN1495165A (zh) 2004-05-12
CZ297416B6 (cs) 2006-12-13
NO992895L (no) 1999-08-13
IS5061A (is) 1999-05-28
UA66778C2 (ru) 2004-06-15
CN1282644C (zh) 2006-11-01
US6352988B2 (en) 2002-03-05
HK1025775A1 (en) 2000-11-24
PL188418B1 (pl) 2005-01-31
KR100432297B1 (ko) 2004-05-20
BG103561A (en) 2000-06-30
AU731243B2 (en) 2001-03-29

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