ES2188155T3 - N-ariloxietilindolilalquilaminas para el tratamiento de la depresion. - Google Patents

N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.

Info

Publication number
ES2188155T3
ES2188155T3 ES99916480T ES99916480T ES2188155T3 ES 2188155 T3 ES2188155 T3 ES 2188155T3 ES 99916480 T ES99916480 T ES 99916480T ES 99916480 T ES99916480 T ES 99916480T ES 2188155 T3 ES2188155 T3 ES 2188155T3
Authority
ES
Spain
Prior art keywords
hydrogen
halogen
aryloxietilindolilalquilamins
depression
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99916480T
Other languages
English (en)
Inventor
Richard Eric Mewshaw
James Albert Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of ES2188155T3 publication Critical patent/ES2188155T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of El Displays (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuesto de fórmula:**(Fórmula)** en el que: R1 es hidrógeno, alquilo de 1 a 6 átomos de carbono, fenilo o fenilo sustituido por halógeno, alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono o ciano; X e Y forman conjuntamente un anillo de lactama, imidazol, imidazolona o tioimidazolona; Z es hidrógeno, halógeno o alcoxi de 1 a 6 átomos de carbono; W es hidrógeno, halógeno, alcoxi de 1 a 6 átomos de carbono, alquilo de 1 a 6 átomos de carbono, ciano, o un grupo trifluororometilo; y n = 2 a 5; o una sal de los mismos, aceptable desde el punto de vista farmacéutico.
ES99916480T 1998-04-08 1999-04-07 N-ariloxietilindolilalquilaminas para el tratamiento de la depresion. Expired - Lifetime ES2188155T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5715998A 1998-04-08 1998-04-08

Publications (1)

Publication Number Publication Date
ES2188155T3 true ES2188155T3 (es) 2003-06-16

Family

ID=22008868

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99916480T Expired - Lifetime ES2188155T3 (es) 1998-04-08 1999-04-07 N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.

Country Status (11)

Country Link
EP (1) EP1068199B1 (es)
JP (1) JP2002510681A (es)
CN (1) CN1135228C (es)
AT (1) ATE227718T1 (es)
AU (1) AU3479299A (es)
CA (1) CA2327513A1 (es)
DE (1) DE69903930T2 (es)
DK (1) DK1068199T3 (es)
ES (1) ES2188155T3 (es)
PT (1) PT1068199E (es)
WO (1) WO1999051591A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108993496B (zh) * 2018-10-30 2021-01-15 山东第一医科大学(山东省医学科学院) 一种治疗运动障碍用药物罗匹尼罗中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
DK37790A (da) * 1990-02-13 1991-08-14 Novo Nordisk As Indolderivater, deres fremstilling og anvendelse
US5189179A (en) * 1990-08-29 1993-02-23 Merrell Dow Pharmaceuticals Inc. Serotonin 5ht1a agonists
JPH05255302A (ja) * 1992-03-09 1993-10-05 Yamanouchi Pharmaceut Co Ltd 新規なクロマニルオキシアルキルアミン誘導体
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
JPH0940648A (ja) * 1995-08-02 1997-02-10 Yamanouchi Pharmaceut Co Ltd 新規な８−（２−アミノアルコキシ）キノリン誘導体
DE19615232A1 (de) * 1996-04-18 1997-10-23 Merck Patent Gmbh Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
EP0923551B1 (en) * 1996-08-27 2002-06-05 American Home Products Corporation 4-aminoethoxy indolone derivatives
ATE234281T1 (de) * 1996-08-27 2003-03-15 Wyeth Corp 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives

Also Published As

Publication number Publication date
CA2327513A1 (en) 1999-10-14
DK1068199T3 (da) 2003-03-03
CN1304407A (zh) 2001-07-18
WO1999051591A2 (en) 1999-10-14
DE69903930T2 (de) 2003-07-17
DE69903930D1 (de) 2002-12-19
EP1068199B1 (en) 2002-11-13
ATE227718T1 (de) 2002-11-15
WO1999051591A3 (en) 1999-12-09
AU3479299A (en) 1999-10-25
EP1068199A2 (en) 2001-01-17
CN1135228C (zh) 2004-01-21
JP2002510681A (ja) 2002-04-09
PT1068199E (pt) 2003-02-28

Similar Documents

Publication Publication Date Title
DK0616807T3 (da) Benzimidazol anvendelig i behandlingen af forstyrrelser i centralnervesystemet
MX9800187A (es) Compuestos de benzolactama substituidos como antagonistas de la substancia p.
HK1026691A1 (en) Substituted benzimidazoles and their use for treating retroviral infection
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
BR9910621A (pt) Novos compostos de imidazol 2-alquil substituìdos
PT1159279E (pt) 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
EA199800170A1 (ru) Производные 2-(4-замещенного)бензиламино-2-метилпропанамида
CO5090829A1 (es) Compuestos organicos de la formula i, utiles como inhibido res de la proteina de transferencia de triglicerido microso mal y de la secrecion de la apolipoproteina b.
MX9806171A (es) Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.
HRP20000585B1 (en) Substituted bisindolymaleimides for the inhibition of cell proliferation
ATE224372T1 (de) Substituierte 6-alkylphenanthridine
ES2071479T3 (es) Derivados de indano.
ES2182509T3 (es) Derivados de n-ariloxietilamina para el tratamiento de la depresion.
CA2285535A1 (en) Benzimidazole derivative for treating allergy-related disease
ES2188155T3 (es) N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.
ATE191465T1 (de) Carbamoylcarbonsäureamide
ATE238300T1 (de) (3,4-dihydro-2h-benzo(1,4)oxazinyl-methyl)-3-(1 - indol-3-yl)-alkylamine
SV2002000573A (es) Proceso para preparar 2-(4-piridil) amino-6- dialquiloxifenil-pirido[2,3-d] pirimidin-7-onas
SE9704770D0 (sv) New use
CA2296586A1 (en) New 2,3-benzodiazepine derivatives
PT1049670E (pt) Derivados de azetidinocarboxamida para o tratamento de perturbacoes do snc
ES2182775T3 (es) Derivados de ciclohexano 1,4-disustituidos para el tratamiento de la depresion.
MX9204939A (es) Inhibidores 5-bis-aminometilen-1,3-dioxan-4,6-diona n,n&#39;,n&#39;-trisubstituidas, de la acil coenzima a: colesterol-aciltransferasa.