ES2182509T3 - Derivados de n-ariloxietilamina para el tratamiento de la depresion. - Google Patents

Derivados de n-ariloxietilamina para el tratamiento de la depresion.

Info

Publication number
ES2182509T3
ES2182509T3 ES99915318T ES99915318T ES2182509T3 ES 2182509 T3 ES2182509 T3 ES 2182509T3 ES 99915318 T ES99915318 T ES 99915318T ES 99915318 T ES99915318 T ES 99915318T ES 2182509 T3 ES2182509 T3 ES 2182509T3
Authority
ES
Spain
Prior art keywords
hydrogen
halogen
lower alkyl
alkoxy
aryloxyethylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99915318T
Other languages
English (en)
Inventor
Richard Eric Mewshaw
Dahui Zhou
Ping Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of ES2182509T3 publication Critical patent/ES2182509T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto de fórmula en la que: R1 y R2 son cada uno, de modo independiente, hidrógeno, halógeno, CF3, alquilo C1-C6, alcoxi C1-C6, MeSO2, o pueden formar juntos un anillo carbocíclico o heterocíclico de 5-7 miembros, que contiene 1, 2 ó 3 heteroátomos, que pueden ser iguales o distintos, seleccionados a partir de O, N ó S; R3 es halógeno, hidrógeno o carbamoílo; R4 es hidrógeno, hidroxi, alquilo C1-C6 o alcoxi C1-C6; R5 es hidrógeno, alquilo inferior C1-C6 ó halógeno; R6 es hidrógeno, alquilo inferior C1-C6 ó fenilo; R7 es hidrógeno, alquilo C1-C6, alcoxi C1-C6, halógeno, CN, CF3 ó hidroxi; y X es (CH2)n, donde n es 0 a 3; o sales de los mismos, aceptables desde el punto de vista farmacéutico.
ES99915318T 1998-04-08 1999-04-07 Derivados de n-ariloxietilamina para el tratamiento de la depresion. Expired - Lifetime ES2182509T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5730798A 1998-04-08 1998-04-08

Publications (1)

Publication Number Publication Date
ES2182509T3 true ES2182509T3 (es) 2003-03-01

Family

ID=22009801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99915318T Expired - Lifetime ES2182509T3 (es) 1998-04-08 1999-04-07 Derivados de n-ariloxietilamina para el tratamiento de la depresion.

Country Status (11)

Country Link
EP (1) EP1068184B1 (es)
JP (1) JP2002510676A (es)
CN (1) CN1160332C (es)
AT (1) ATE223379T1 (es)
AU (1) AU3386299A (es)
CA (1) CA2327303A1 (es)
DE (1) DE69902766T2 (es)
DK (1) DK1068184T3 (es)
ES (1) ES2182509T3 (es)
PT (1) PT1068184E (es)
WO (1) WO1999051576A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0015401A (pt) * 1999-11-08 2002-07-02 Wyeth Corp [(indol-3-il)-cicloalquil]-3-azetidinas substituìdas para o tratamento de distúrbios do sistema nervoso central
DE10006139A1 (de) * 2000-02-11 2001-08-16 Merck Patent Gmbh Indol-3-yl-Derivate
EP1373203A1 (en) 2001-03-29 2004-01-02 Bristol-Myers Squibb Company Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
US7041697B2 (en) * 2002-09-12 2006-05-09 Wyeth Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
DE10305739A1 (de) * 2003-02-11 2004-08-19 Merck Patent Gmbh Benzofuranderivate
DE10306941A1 (de) 2003-02-18 2004-08-26 Merck Patent Gmbh Benzofuranoxyethylamine
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
WO2009128088A2 (en) * 2008-04-15 2009-10-22 Shodhana Laboratories Limited Preparation of 2-(2-alkoxy phenoxy) ethylamine, an intermediate of carvedilol and tamsulosin
CN112358450A (zh) * 2020-11-19 2021-02-12 南京艾康生物科技有限公司 一种4-(苄氧基)-2-甲基-1H-苯并[d]咪唑-6-羧酸的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
US3371098A (en) * 1966-11-29 1968-02-27 Philips Corp 5- and 6-methoxy-3-(phenoxyethyl-aminoethyl)-indoles
DE2827874A1 (de) * 1978-06-24 1980-02-07 Merck Patent Gmbh Indolalkylamine und verfahren zu ihrer herstellung
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US5124332A (en) * 1991-01-28 1992-06-23 Warner-Lambert Company Substituted indoles as central nervous system agents
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
JPH05125024A (ja) * 1991-11-05 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアリールオキシアルキルアミン誘導体又はその塩
US5314896A (en) * 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
JPH05255302A (ja) * 1992-03-09 1993-10-05 Yamanouchi Pharmaceut Co Ltd 新規なクロマニルオキシアルキルアミン誘導体
IT1271352B (it) * 1993-04-08 1997-05-27 Boehringer Ingelheim Italia Derivati dell'indolo utili nel trattamento dei disturbi del sistema nervoso centrale
US5436264A (en) * 1993-08-19 1995-07-25 Syntex (U.S.A.) Inc. N-aryloxyalkyl tryptamine α1 -adrenergic receptor antagonists
US5468767A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
JPH0940648A (ja) * 1995-08-02 1997-02-10 Yamanouchi Pharmaceut Co Ltd 新規な８−（２−アミノアルコキシ）キノリン誘導体
ES2179362T3 (es) * 1996-08-27 2003-01-16 Wyeth Corp Derivados de 4-aminoetoxi indolona.
CN1234023A (zh) * 1996-08-27 1999-11-03 美国家用产品公司 作为多巴胺d2激动剂和5ht1a的配位体的4－氨基乙氧基吲哚

Also Published As

Publication number Publication date
DE69902766T2 (de) 2003-02-06
WO1999051576A1 (en) 1999-10-14
DK1068184T3 (da) 2002-12-30
JP2002510676A (ja) 2002-04-09
EP1068184B1 (en) 2002-09-04
CN1303373A (zh) 2001-07-11
PT1068184E (pt) 2002-12-31
DE69902766D1 (de) 2002-10-10
EP1068184A1 (en) 2001-01-17
CA2327303A1 (en) 1999-10-14
ATE223379T1 (de) 2002-09-15
AU3386299A (en) 1999-10-25
CN1160332C (zh) 2004-08-04

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