DE602005016836D1 - Chotischer und anxiolytischer aktivität - Google Patents
Chotischer und anxiolytischer aktivitätInfo
- Publication number
- DE602005016836D1 DE602005016836D1 DE602005016836T DE602005016836T DE602005016836D1 DE 602005016836 D1 DE602005016836 D1 DE 602005016836D1 DE 602005016836 T DE602005016836 T DE 602005016836T DE 602005016836 T DE602005016836 T DE 602005016836T DE 602005016836 D1 DE602005016836 D1 DE 602005016836D1
- Authority
- DE
- Germany
- Prior art keywords
- receptors
- chotic
- towards dopamine
- affinity
- anxiolytic activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04106123 | 2004-11-26 | ||
PCT/EP2005/056229 WO2006056600A1 (en) | 2004-11-26 | 2005-11-25 | Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005016836D1 true DE602005016836D1 (de) | 2009-11-05 |
Family
ID=34929957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005016836T Active DE602005016836D1 (de) | 2004-11-26 | 2005-11-25 | Chotischer und anxiolytischer aktivität |
Country Status (10)
Country | Link |
---|---|
US (1) | US7635696B2 (de) |
EP (1) | EP1819713B1 (de) |
JP (1) | JP2008521771A (de) |
CN (1) | CN101084225B (de) |
AT (1) | ATE443707T1 (de) |
AU (1) | AU2005308778B2 (de) |
CA (1) | CA2585857A1 (de) |
DE (1) | DE602005016836D1 (de) |
ES (1) | ES2331144T3 (de) |
WO (1) | WO2006056600A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8653069B2 (en) * | 2008-07-28 | 2014-02-18 | Jiangsu Hengyi Pharmaceutical Co., Ltd. | Aralkyl substituted piperidine or piperazine derivatives and their use for treating schizophrenia |
US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
US8829001B2 (en) | 2008-10-10 | 2014-09-09 | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
EP2263672A1 (de) * | 2009-05-19 | 2010-12-22 | Bioprojet | Neuartige pharmazeutisch unbedenkliche Salze von 4-(1H-Imidazol-4-ylmethyl)pyridin und ihre therapeutischen Verwendungen |
JP2014500277A (ja) * | 2010-12-09 | 2014-01-09 | アムジエン・インコーポレーテツド | Pim阻害剤としての二環式化合物 |
JP2014510105A (ja) | 2011-03-22 | 2014-04-24 | アムジエン・インコーポレーテツド | Pim阻害剤としてのアゾール化合物 |
WO2023114325A1 (en) * | 2021-12-15 | 2023-06-22 | Delix Therapeutics, Inc. | Constrained amine psychoplastogens and uses thereof |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965595A (en) | 1993-07-01 | 1999-10-12 | The Procter & Gamble Company | 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists |
US5698571A (en) | 1994-10-05 | 1997-12-16 | Eli Lilly And Company | 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine |
CA2272327A1 (en) | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
CN1155567C (zh) | 1998-04-29 | 2004-06-30 | 惠氏公司 | 抑制精神的吲哚基衍生物 |
TW546299B (en) | 1999-01-07 | 2003-08-11 | Wyeth Corp | 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines |
US6313126B1 (en) | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
WO2000040581A1 (en) | 1999-01-07 | 2000-07-13 | American Home Products Corporation | 3,4-dihydro-2h-benzo[1,4]oxazine derivatives |
AR028475A1 (es) | 1999-04-22 | 2003-05-14 | Wyeth Corp | Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion. |
WO2000069424A2 (en) * | 1999-05-12 | 2000-11-23 | Solvay Pharmaceuticals B.V. | Method of treating psychotic disorders |
FR2797874B1 (fr) | 1999-08-27 | 2002-03-29 | Adir | Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2002048105A2 (en) | 2000-11-16 | 2002-06-20 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
AU2002235250A1 (en) | 2000-11-17 | 2002-05-27 | Wyeth | Aryloxy piperidinyl indoles for treating depression |
HUP0303270A3 (en) * | 2001-02-21 | 2007-03-28 | Janssen Pharmaceutica Nv | Isoxazoline derivatives as anti-depressants, process for their preparation and pharmaceutical compositions containing them |
US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
US6800641B2 (en) * | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene |
US6800648B2 (en) * | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one |
SK652004A3 (en) | 2001-06-29 | 2004-09-08 | Lundbeck & Co As H | Heteroaryl derivatives, pharmaceutical composition with the content thereof and use of the same |
DE60206043T2 (de) | 2001-06-29 | 2006-06-29 | H. Lundbeck A/S, Valby | Neue indolderivate |
US6903110B2 (en) | 2001-07-25 | 2005-06-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene |
ATE372342T1 (de) | 2002-04-02 | 2007-09-15 | Janssen Pharmaceutica Nv | Substituierte aminoisoxazolinderivate und ihre verwendung als antidepressiva |
TW200409777A (en) | 2002-08-12 | 2004-06-16 | Janssen Pharmaceutica Nv | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants |
CN100522972C (zh) * | 2002-08-15 | 2009-08-05 | 詹森药业有限公司 | 稠合杂环异噁唑啉衍生物和它们作为抗抑郁剂的用途 |
DE60319388T2 (de) * | 2002-08-21 | 2009-02-19 | Janssen Pharmaceutica N.V. | C6- und C9-substituierte Chromeno[4,3-c]Isoxazoline und ihre Verwendung als Anti-Depressiva |
US7227023B2 (en) * | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
-
2005
- 2005-11-25 AT AT05816247T patent/ATE443707T1/de not_active IP Right Cessation
- 2005-11-25 CN CN2005800401275A patent/CN101084225B/zh not_active Expired - Fee Related
- 2005-11-25 JP JP2007541989A patent/JP2008521771A/ja active Pending
- 2005-11-25 EP EP05816247A patent/EP1819713B1/de active Active
- 2005-11-25 DE DE602005016836T patent/DE602005016836D1/de active Active
- 2005-11-25 ES ES05816247T patent/ES2331144T3/es active Active
- 2005-11-25 CA CA002585857A patent/CA2585857A1/en not_active Abandoned
- 2005-11-25 US US11/791,510 patent/US7635696B2/en not_active Expired - Fee Related
- 2005-11-25 AU AU2005308778A patent/AU2005308778B2/en not_active Ceased
- 2005-11-25 WO PCT/EP2005/056229 patent/WO2006056600A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2008521771A (ja) | 2008-06-26 |
WO2006056600A1 (en) | 2006-06-01 |
EP1819713A1 (de) | 2007-08-22 |
US7635696B2 (en) | 2009-12-22 |
CN101084225B (zh) | 2011-03-02 |
ATE443707T1 (de) | 2009-10-15 |
US20080113988A1 (en) | 2008-05-15 |
CN101084225A (zh) | 2007-12-05 |
EP1819713B1 (de) | 2009-09-23 |
CA2585857A1 (en) | 2006-06-01 |
AU2005308778A1 (en) | 2006-06-01 |
AU2005308778B2 (en) | 2011-03-24 |
ES2331144T3 (es) | 2009-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |