DE602005016836D1 - Chotischer und anxiolytischer aktivität - Google Patents

Chotischer und anxiolytischer aktivität

Info

Publication number
DE602005016836D1
DE602005016836D1 DE602005016836T DE602005016836T DE602005016836D1 DE 602005016836 D1 DE602005016836 D1 DE 602005016836D1 DE 602005016836 T DE602005016836 T DE 602005016836T DE 602005016836 T DE602005016836 T DE 602005016836T DE 602005016836 D1 DE602005016836 D1 DE 602005016836D1
Authority
DE
Germany
Prior art keywords
receptors
chotic
towards dopamine
affinity
anxiolytic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005016836T
Other languages
English (en)
Inventor
Jose I Andres-Gil
Jose M Bartolome-Nebreda
Manuel J Alcazar-Vaca
M Garcia-Martin
Antonius A H P Megens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005016836D1 publication Critical patent/DE602005016836D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602005016836T 2004-11-26 2005-11-25 Chotischer und anxiolytischer aktivität Active DE602005016836D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106123 2004-11-26
PCT/EP2005/056229 WO2006056600A1 (en) 2004-11-26 2005-11-25 Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity

Publications (1)

Publication Number Publication Date
DE602005016836D1 true DE602005016836D1 (de) 2009-11-05

Family

ID=34929957

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005016836T Active DE602005016836D1 (de) 2004-11-26 2005-11-25 Chotischer und anxiolytischer aktivität

Country Status (10)

Country Link
US (1) US7635696B2 (de)
EP (1) EP1819713B1 (de)
JP (1) JP2008521771A (de)
CN (1) CN101084225B (de)
AT (1) ATE443707T1 (de)
AU (1) AU2005308778B2 (de)
CA (1) CA2585857A1 (de)
DE (1) DE602005016836D1 (de)
ES (1) ES2331144T3 (de)
WO (1) WO2006056600A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101457339B1 (ko) * 2008-07-28 2014-11-03 지앙쑤 구오후아 인베스트먼트 컴퍼니 리미티드 아랄킬 치환된 피페리딘 또는 피페라진 유도체 및 정신분열증 치료를 위한 이의 용도
WO2010040274A1 (zh) * 2008-10-10 2010-04-15 中国人民解放军军事医学科学院毒物药物研究所 新型多巴胺d3受体配体，其制备方法及其医药用途
US9227944B2 (en) 2008-10-10 2016-01-05 Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China Dopamine D3 receptor ligands and preparation and medical uses of the same
EP2263672A1 (de) * 2009-05-19 2010-12-22 Bioprojet Neuartige pharmazeutisch unbedenkliche Salze von 4-(1H-Imidazol-4-ylmethyl)pyridin und ihre therapeutischen Verwendungen
EP2796456A1 (de) * 2010-12-09 2014-10-29 Amgen Inc. Bicyclische Verbindungen als PIM-Hemmer
US9321756B2 (en) 2011-03-22 2016-04-26 Amgen Inc. Azole compounds as PIM inhibitors
WO2023114325A1 (en) * 2021-12-15 2023-06-22 Delix Therapeutics, Inc. Constrained amine psychoplastogens and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965595A (en) * 1993-07-01 1999-10-12 The Procter & Gamble Company 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US5698571A (en) 1994-10-05 1997-12-16 Eli Lilly And Company 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
EP0943613A4 (de) 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk Sauerstoff enthaltende heterocyclische verbindungen
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
WO1999055672A2 (en) 1998-04-29 1999-11-04 American Home Products Corporation Antipsychotic indolyl derivatives
US6313126B1 (en) * 1999-01-07 2001-11-06 American Home Products Corp Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
TW546299B (en) 1999-01-07 2003-08-11 Wyeth Corp 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines
AU2494300A (en) 1999-01-07 2000-07-24 American Home Products Corporation 3,4-dihydro-2h-benzo(1,4)oxazine derivatives
AR028475A1 (es) 1999-04-22 2003-05-14 Wyeth Corp Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion.
AU4552200A (en) * 1999-05-12 2000-12-05 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
FR2797874B1 (fr) 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2002048105A2 (en) 2000-11-16 2002-06-20 Wyeth Aryloxy piperidinyl derivatives for the treatment of depression
EP1349848A2 (de) 2000-11-17 2003-10-08 Wyeth Aryloxy-piperidinylindole für die behandlung von depressionen
SK11612003A3 (sk) * 2001-02-21 2004-04-06 Janssen Pharmaceutica N. V. Izoxazolínové deriváty ako antidepresívne činidlá
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US6800648B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6800641B2 (en) * 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
SI1399438T1 (sl) 2001-06-29 2006-04-30 Lundbeck & Co As H Novi heteroarilni derivati, njihova priprava in uporaba
JP2004535448A (ja) 2001-06-29 2004-11-25 ハー・ルンドベック・アクチエゼルスカベット 新規インドール誘導体
WO2003010169A1 (en) 2001-07-25 2003-02-06 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene
EP1492796B1 (de) 2002-04-02 2007-09-05 Janssen Pharmaceutica N.V. Substituierte aminoisoxazolinderivate und ihre verwendung als antidepressiva
AR040967A1 (es) 2002-08-12 2005-04-27 Janssen Pharmaceutica Nv Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos
EP1554286B1 (de) 2002-08-15 2010-01-27 Janssen Pharmaceutica N.V. Kondensierte heterocyclische isoxazolinderivate und deren verwendung als antidepressiva
ATE387455T1 (de) * 2002-08-21 2008-03-15 Janssen Pharmaceutica Nv C6- und c9-substituierte chromeno(4,3- c)isoxazoline und ihre verwendung als anti- depressiva
US7227023B2 (en) * 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives

Also Published As

Publication number Publication date
AU2005308778A1 (en) 2006-06-01
ES2331144T3 (es) 2009-12-22
JP2008521771A (ja) 2008-06-26
CN101084225B (zh) 2011-03-02
US20080113988A1 (en) 2008-05-15
EP1819713B1 (de) 2009-09-23
WO2006056600A1 (en) 2006-06-01
AU2005308778B2 (en) 2011-03-24
CN101084225A (zh) 2007-12-05
ATE443707T1 (de) 2009-10-15
EP1819713A1 (de) 2007-08-22
CA2585857A1 (en) 2006-06-01
US7635696B2 (en) 2009-12-22

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