ATE443707T1 - Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität - Google Patents
Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivitätInfo
- Publication number
- ATE443707T1 ATE443707T1 AT05816247T AT05816247T ATE443707T1 AT E443707 T1 ATE443707 T1 AT E443707T1 AT 05816247 T AT05816247 T AT 05816247T AT 05816247 T AT05816247 T AT 05816247T AT E443707 T1 ATE443707 T1 AT E443707T1
- Authority
- AT
- Austria
- Prior art keywords
- indole derivatives
- isoxazoline
- receptors
- anxiolytic activity
- towards dopamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04106123 | 2004-11-26 | ||
PCT/EP2005/056229 WO2006056600A1 (en) | 2004-11-26 | 2005-11-25 | Isoxazoline-indole derivatives with an improved antipsychotic and anxiolytic a ivity |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE443707T1 true ATE443707T1 (de) | 2009-10-15 |
Family
ID=34929957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05816247T ATE443707T1 (de) | 2004-11-26 | 2005-11-25 | Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität |
Country Status (10)
Country | Link |
---|---|
US (1) | US7635696B2 (de) |
EP (1) | EP1819713B1 (de) |
JP (1) | JP2008521771A (de) |
CN (1) | CN101084225B (de) |
AT (1) | ATE443707T1 (de) |
AU (1) | AU2005308778B2 (de) |
CA (1) | CA2585857A1 (de) |
DE (1) | DE602005016836D1 (de) |
ES (1) | ES2331144T3 (de) |
WO (1) | WO2006056600A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010012121A1 (zh) * | 2008-07-28 | 2010-02-04 | 江苏国华投资有限公司 | 芳烷基哌啶(嗪)衍生物及其在治疗精神分裂症中的应用 |
WO2010040274A1 (zh) * | 2008-10-10 | 2010-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 新型多巴胺d3受体配体,其制备方法及其医药用途 |
US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
EP2263672A1 (de) * | 2009-05-19 | 2010-12-22 | Bioprojet | Neuartige pharmazeutisch unbedenkliche Salze von 4-(1H-Imidazol-4-ylmethyl)pyridin und ihre therapeutischen Verwendungen |
EP2796456A1 (de) * | 2010-12-09 | 2014-10-29 | Amgen Inc. | Bicyclische Verbindungen als PIM-Hemmer |
US9321756B2 (en) | 2011-03-22 | 2016-04-26 | Amgen Inc. | Azole compounds as PIM inhibitors |
WO2023114325A1 (en) * | 2021-12-15 | 2023-06-22 | Delix Therapeutics, Inc. | Constrained amine psychoplastogens and uses thereof |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965595A (en) | 1993-07-01 | 1999-10-12 | The Procter & Gamble Company | 2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists |
US5698571A (en) | 1994-10-05 | 1997-12-16 | Eli Lilly And Company | 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine |
WO1998022455A1 (fr) | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Composes heterocycliques d'oxygene |
ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
AR015036A1 (es) | 1998-04-29 | 2001-04-11 | American Home Prod | Derivados de indolilo antisicoticos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
TW546299B (en) | 1999-01-07 | 2003-08-11 | Wyeth Corp | 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines |
US6313126B1 (en) | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
AU2494300A (en) | 1999-01-07 | 2000-07-24 | American Home Products Corporation | 3,4-dihydro-2h-benzo(1,4)oxazine derivatives |
AR028475A1 (es) | 1999-04-22 | 2003-05-14 | Wyeth Corp | Derivados de azaindol y uso de los mismos para la manufactura de un medicamento para el tratamiento de la depresion. |
WO2000069424A2 (en) * | 1999-05-12 | 2000-11-23 | Solvay Pharmaceuticals B.V. | Method of treating psychotic disorders |
FR2797874B1 (fr) | 1999-08-27 | 2002-03-29 | Adir | Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2002048105A2 (en) | 2000-11-16 | 2002-06-20 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
EP1349848A2 (de) | 2000-11-17 | 2003-10-08 | Wyeth | Aryloxy-piperidinylindole für die behandlung von depressionen |
EE200300398A (et) * | 2001-02-21 | 2003-12-15 | Janssen Pharmaceutica N.V. | Isoksasoliini derivaat, selle saamine ja kasutamine depresioonivastase ravimi valmistamiseks ning seda sisaldav ravimkompositsioon |
US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
US6800641B2 (en) * | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene |
US6800648B2 (en) * | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one |
CZ2004155A3 (cs) | 2001-06-29 | 2004-07-14 | H. Lundbeck A/S | Název neuveden |
UA75407C2 (en) | 2001-06-29 | 2006-04-17 | Lundbeck & Co As H | Heteroaryl derivatives of pyridine and pyrimidine, pharmaceutical composition and use thereof |
WO2003010169A1 (en) | 2001-07-25 | 2003-02-06 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7, 8-dihydro-6h-5-oxa-1-aza-phenanthrene |
EP1492796B1 (de) | 2002-04-02 | 2007-09-05 | Janssen Pharmaceutica N.V. | Substituierte aminoisoxazolinderivate und ihre verwendung als antidepressiva |
AR040967A1 (es) | 2002-08-12 | 2005-04-27 | Janssen Pharmaceutica Nv | Derivados de isoxazolina triciclicos c- sustituidos y su uso como anti- depresivos |
ES2339444T3 (es) * | 2002-08-15 | 2010-05-20 | Janssen Pharmaceutica Nv | Derivados de isoxazolina heterociclicos condensados y su uso como antidepresivos. |
WO2004018482A2 (en) * | 2002-08-21 | 2004-03-04 | Janssen Pharmaceutica N.V. | C6- and c9-substituted chromeno[4, 3-c]isoxazoline derivatives and their use as anti-depressants |
US7227023B2 (en) * | 2003-04-30 | 2007-06-05 | Wyeth | Quinoline 3-amino chroman derivatives |
-
2005
- 2005-11-25 CA CA002585857A patent/CA2585857A1/en not_active Abandoned
- 2005-11-25 DE DE602005016836T patent/DE602005016836D1/de active Active
- 2005-11-25 CN CN2005800401275A patent/CN101084225B/zh not_active Expired - Fee Related
- 2005-11-25 AU AU2005308778A patent/AU2005308778B2/en not_active Ceased
- 2005-11-25 WO PCT/EP2005/056229 patent/WO2006056600A1/en active Application Filing
- 2005-11-25 JP JP2007541989A patent/JP2008521771A/ja active Pending
- 2005-11-25 AT AT05816247T patent/ATE443707T1/de not_active IP Right Cessation
- 2005-11-25 ES ES05816247T patent/ES2331144T3/es active Active
- 2005-11-25 US US11/791,510 patent/US7635696B2/en not_active Expired - Fee Related
- 2005-11-25 EP EP05816247A patent/EP1819713B1/de active Active
Also Published As
Publication number | Publication date |
---|---|
AU2005308778B2 (en) | 2011-03-24 |
JP2008521771A (ja) | 2008-06-26 |
US7635696B2 (en) | 2009-12-22 |
CA2585857A1 (en) | 2006-06-01 |
DE602005016836D1 (de) | 2009-11-05 |
US20080113988A1 (en) | 2008-05-15 |
EP1819713A1 (de) | 2007-08-22 |
AU2005308778A1 (en) | 2006-06-01 |
CN101084225B (zh) | 2011-03-02 |
CN101084225A (zh) | 2007-12-05 |
EP1819713B1 (de) | 2009-09-23 |
WO2006056600A1 (en) | 2006-06-01 |
ES2331144T3 (es) | 2009-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |