AR015036A1 - Derivados de indolilo antisicoticos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento - Google Patents
Derivados de indolilo antisicoticos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamentoInfo
- Publication number
- AR015036A1 AR015036A1 ARP990101975A ARP990101975A AR015036A1 AR 015036 A1 AR015036 A1 AR 015036A1 AR P990101975 A ARP990101975 A AR P990101975A AR P990101975 A ARP990101975 A AR P990101975A AR 015036 A1 AR015036 A1 AR 015036A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- alkoxy
- manufacture
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Derivados de indolilo antisicotico de la formula general (1) en donde: R1 y R2 son cada uno independientemente seleccionados entre H, OH, F, Cl, Br, I,alquilo C1-6 o alquenilo C1-6, alcoxi C1-6, arilo, OR5, nitro, amino, CF3, fenilo, bencilo, benciloxi o piridina, los anillos aromáticos de los cuales sonoptativamente sustituidos por entre 1 a 3 sustituyentes seleccionados entre halogeno, alquilo C1-6, alcoxi C1-6, S-alquilo C1-6, -CN, -OH, -NO2 o CF3; o R1 yR2 son tomados conjuntamente, forman un anillo fusionado en las posiciones 1,2 o 2,3 proporcionando un grupo fenilo fusionado o un grupo benzodioxano, o ungrupo indol 4- o 7-sustituido, o un grupo quinolina 4- o 5- u 8-sustituido; R3 representa un grupo seleccionado entre hidrogeno, alquilo C1-6, alcoxi C1-4 o unhalogeno; R4 representa un grupo seleccionado entre hidrogeno, alquilo C1-6 o R5; R5 es CH2Ph en el cual el anillo fenilo puede estar optativamente sustituidopor un grupo seleccionado entre OMe, halogeno, CF3; X se selecciona entre un grupo representado por N, CR4, CHR4 y CHCH; A se selecciona entre un gruporepresentado por N, NH, CH y CH2; B se selecciona entre un grupo representado por =O, =S, H y H2; o A y B pueden estar concatenados juntos para formarporciones indol, benzimidazol, indolona o indolina; o su sal farmacéuticamente aceptable; composiciones farmacéuticas para el tratamiento de los trastornos delsistema nervioso central utilizando estos compuestos y su uso para la manufactura de un medicamento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6912998A | 1998-04-29 | 1998-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR015036A1 true AR015036A1 (es) | 2001-04-11 |
Family
ID=22086935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990101975A AR015036A1 (es) | 1998-04-29 | 1999-04-28 | Derivados de indolilo antisicoticos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1076647A2 (es) |
JP (1) | JP2002513001A (es) |
CN (1) | CN1155567C (es) |
AR (1) | AR015036A1 (es) |
AU (1) | AU3667899A (es) |
CA (1) | CA2330452A1 (es) |
WO (1) | WO1999055672A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0011542A (pt) | 1999-05-24 | 2002-03-05 | Mitsubishi Pharma Corp | Compostos de fenoxipropilamina |
AU1057401A (en) * | 1999-11-11 | 2001-06-06 | Senju Pharmaceutical Co., Ltd. | Pancreatitis remedies |
EP1242419A1 (en) * | 1999-12-20 | 2002-09-25 | Eli Lilly And Company | Azabicyclo 3.2.1]octane derivatives |
AU2049601A (en) * | 1999-12-20 | 2001-07-03 | Eli Lilly And Company | Benzofuran derivatives |
AR027134A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de indol. |
RU2283648C2 (ru) * | 2000-11-14 | 2006-09-20 | Мерк Патент Гмбх | Новое применение комбинированных селективных антагонистов допаминового рецептора d2 и агонистов рецептора 5-нт 1a |
AU2002243394A1 (en) | 2000-11-16 | 2002-06-24 | Wyeth | Aryloxy piperidinyl derivatives for the treatment of depression |
AU2002224105A1 (en) * | 2000-11-27 | 2002-06-03 | Mitsubishi Pharma Corporation | Piperidine compounds and medicinal use thereof |
SK642004A3 (en) * | 2001-06-29 | 2004-05-04 | Lundbeck & Co As H | Novel indole derivatives |
SI1408964T1 (sl) | 2001-07-26 | 2007-06-30 | Merck Patent Gmbh | Uporaba 2- 5-(4-fluorofenil)-3-piridilmetil-aminometil -kromana in njegovih fizioloĺ ko sprejemljivih soli |
AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
RU2007101509A (ru) | 2004-06-17 | 2008-07-27 | Уайт (Us) | Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин |
BRPI0512261A (pt) | 2004-06-17 | 2008-02-26 | Wyeth Corp | antagonistas de receptor de hormÈnio liberador de gonadotropina |
DE602005016836D1 (de) | 2004-11-26 | 2009-11-05 | Janssen Pharmaceutica Nv | Chotischer und anxiolytischer aktivität |
US7538113B2 (en) | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7534796B2 (en) | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
US7582636B2 (en) | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
CN101263136A (zh) | 2005-07-13 | 2008-09-10 | 弗·哈夫曼-拉罗切有限公司 | 作为5-ht6、5-ht24的苯并咪唑衍生物 |
MX2009004898A (es) | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Derivados de indol y de benzofurano-2-carboxamida. |
KR101457339B1 (ko) | 2008-07-28 | 2014-11-03 | 지앙쑤 구오후아 인베스트먼트 컴퍼니 리미티드 | 아랄킬 치환된 피페리딘 또는 피페라진 유도체 및 정신분열증 치료를 위한 이의 용도 |
CN101973925B (zh) * | 2010-10-15 | 2012-03-28 | 中国药科大学 | 具有抗炎活性的2-吲哚酮类化合物、其制备方法及医药用途 |
PL395469A1 (pl) * | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
CN102871978B (zh) * | 2012-10-19 | 2014-04-09 | 河北仁合益康药业有限公司 | 一种左舒必利片及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4335126A (en) * | 1977-03-10 | 1982-06-15 | Degussa Aktiengesellschaft | 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity |
FR2567884B1 (fr) * | 1984-07-19 | 1987-03-06 | Roussel Uclaf | Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US5912256A (en) * | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
-
1999
- 1999-04-28 CN CNB998078220A patent/CN1155567C/zh not_active Expired - Fee Related
- 1999-04-28 EP EP99918863A patent/EP1076647A2/en not_active Withdrawn
- 1999-04-28 WO PCT/US1999/009132 patent/WO1999055672A2/en not_active Application Discontinuation
- 1999-04-28 CA CA002330452A patent/CA2330452A1/en not_active Abandoned
- 1999-04-28 JP JP2000545832A patent/JP2002513001A/ja active Pending
- 1999-04-28 AR ARP990101975A patent/AR015036A1/es unknown
- 1999-04-28 AU AU36678/99A patent/AU3667899A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2330452A1 (en) | 1999-11-04 |
JP2002513001A (ja) | 2002-05-08 |
AU3667899A (en) | 1999-11-16 |
CN1155567C (zh) | 2004-06-30 |
WO1999055672A3 (en) | 2000-01-20 |
EP1076647A2 (en) | 2001-02-21 |
WO1999055672A2 (en) | 1999-11-04 |
CN1307562A (zh) | 2001-08-08 |
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