AR056613A1 - Compuestos derivados de lapachona, su preparacion y metodos de uso de los mismos para el tratamiento o prevencion de trastornos proliferativos celulares y composiciones farmaceuticas que los contienen - Google Patents
Compuestos derivados de lapachona, su preparacion y metodos de uso de los mismos para el tratamiento o prevencion de trastornos proliferativos celulares y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR056613A1 AR056613A1 ARP030104253A ARP030104253A AR056613A1 AR 056613 A1 AR056613 A1 AR 056613A1 AR P030104253 A ARP030104253 A AR P030104253A AR P030104253 A ARP030104253 A AR P030104253A AR 056613 A1 AR056613 A1 AR 056613A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- prevention
- treatment
- lapachona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/08—Naphthothiopyrans; Hydrogenated naphthothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Análogos y derivados de lapachona como así también métodos de uso y de preparacion de los mismos. Estos compuestos pueden ser usados en composiciones farmacéuticas para el tratamiento o la prevencion de trastornos proliferativos celulares. Estos compuestos también pueden ser usados en el tratamiento o la prevencion de psoriasis o cáncer o condiciones pre-cancerosas. Reivindicacion 1: Un compuesto caracterizado por la formula (1) o sales farmacéuticamente aceptables del mismo, o una mezcla regioisomérica del mismo, donde R1-R6 son cada uno, independientemente, seleccionados del grupo formado por H, OH, alquilo C1-6 substituido y no substituido, alquenilo C1-6 substituido y n substituido, alcoxi C1-6 substituido y no substituido, alcoxicarbonilo C1-6 substituido y no substituido, acilo C1-6 substituido y no substituido, -(CH2)n-amino, -(CH2)n-arilo, -(CH2)-heterociclilo, y -(CH2)n-fenilo; o uno de R1 o R2 y uno de R3 o R4; o uno de R3 o R4 y uno de R5 o R6 forman un anillo fusionado, donde el anillo tiene de 4-8 miembros anulares; R7-R10 son cada uno, independientemente, H, hidroxilo, halogeno, alquilo substituido o no substituido, alcoxi substituido o n substituido, nitro, ciano o amida; y n es un entero de 0 a 10.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42728302P | 2002-11-18 | 2002-11-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR056613A1 true AR056613A1 (es) | 2007-10-17 |
Family
ID=34375156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030104253A AR056613A1 (es) | 2002-11-18 | 2003-11-18 | Compuestos derivados de lapachona, su preparacion y metodos de uso de los mismos para el tratamiento o prevencion de trastornos proliferativos celulares y composiciones farmaceuticas que los contienen |
Country Status (12)
Country | Link |
---|---|
US (1) | US20040266857A1 (es) |
EP (1) | EP1567515A4 (es) |
JP (1) | JP2006508147A (es) |
CN (1) | CN1729183A (es) |
AR (1) | AR056613A1 (es) |
AU (1) | AU2003295738A1 (es) |
BR (1) | BR0316296A (es) |
CA (1) | CA2506340A1 (es) |
EA (1) | EA200500849A1 (es) |
MX (1) | MXPA05005314A (es) |
TW (1) | TW200510367A (es) |
WO (1) | WO2004045557A2 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1575580A4 (en) | 2002-12-02 | 2009-06-10 | Arqule Inc | METHODS OF TREATING CANCERS |
EP1694322A2 (en) | 2003-11-26 | 2006-08-30 | Arqule, Inc. | Use of beta-lapachone for protecting against radiation injury |
EP1729760A2 (en) * | 2004-02-20 | 2006-12-13 | Arqule, Inc. | Use of beta-lapachone for the treatment of lung cancer |
CA2556789A1 (en) * | 2004-02-20 | 2005-09-09 | Arqule, Inc. | Use of beta-lapachone for treating hematologic tumors |
WO2005082355A2 (en) * | 2004-02-20 | 2005-09-09 | Arqule, Inc. | Use of beta-lapachone for treatment of colon cancer |
WO2005082353A2 (en) * | 2004-02-20 | 2005-09-09 | Arqule, Inc. | Use of beta-lapachone for treating or preventing cancer |
US20050187288A1 (en) * | 2004-02-20 | 2005-08-25 | Chiang Li | Beta-lapachone and methods of treating cancer |
WO2005082359A2 (en) * | 2004-02-20 | 2005-09-09 | Arqule, Inc. | Use of beta-lapachone for the treatment of pancreatic cancer |
JP2007523192A (ja) * | 2004-02-20 | 2007-08-16 | アークル・インコーポレーテツド | 広域スペクトラム抗癌剤としてのβ−ラパコンの使用 |
WO2006020722A2 (en) | 2004-08-11 | 2006-02-23 | Arqule, Inc. | Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting |
US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
US20060204981A1 (en) | 2005-01-07 | 2006-09-14 | Chiang Li | Compositions for modulation of PARP and methods for screening for same |
WO2006128120A2 (en) * | 2005-05-26 | 2006-11-30 | Arqule, Inc. | Novel lapachone compounds and methods of use thereof |
CA2653472A1 (en) * | 2006-05-26 | 2007-12-06 | Arqule, Inc. | Novel lapachone compounds and methods of use thereof |
TW200824692A (en) | 2006-08-21 | 2008-06-16 | Arqule Inc | Novel lapachone compounds and methods of use thereof |
EP2137168B1 (en) | 2007-03-16 | 2016-09-14 | Lankenau Institute for Medical Research | Novel ido inhibitors and methods of use thereof |
CN101687835B (zh) | 2007-04-30 | 2015-08-19 | 艾科尔公司 | 苯醌化合物的羟基磺酸盐和它们的应用 |
US8067459B2 (en) | 2007-10-16 | 2011-11-29 | Arqule, Inc. | Lapachone compounds and methods of use thereof |
KR101405823B1 (ko) | 2007-12-24 | 2014-06-12 | 주식회사 케이티앤지생명과학 | 녹내장의 치료 및 예방을 위한 약제 조성물 |
KR20090071829A (ko) * | 2007-12-28 | 2009-07-02 | 주식회사 머젠스 | 신장질환의 치료 및 예방을 위한 약제 조성물 |
KR20090073381A (ko) * | 2007-12-31 | 2009-07-03 | 주식회사 머젠스 | 심장질환의 치료 및 예방을 위한 약제 조성물 |
EP2575740A4 (en) * | 2010-06-01 | 2015-09-30 | Belle Aire Fragrances Inc | METHOD AND PRODUCT FOR COMBATTING ORAL ODORS |
WO2017106624A1 (en) | 2015-12-18 | 2017-06-22 | The Board Of Regents Of The University Of Texas System | Napthoquinones, pro-drugs, and methods of use thereof |
KR101735275B1 (ko) | 2016-12-20 | 2017-05-16 | 아주대학교산학협력단 | 베타-라파촌을 포함하는 수면 장애 예방 또는 치료용 조성물 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2011455B (en) * | 1977-12-21 | 1982-03-03 | Ici Ltd | Chemical process |
US5346917A (en) * | 1991-06-10 | 1994-09-13 | Sterling Winthrop Inc. | Thioxanthenone antitumor agents |
US5763625A (en) * | 1995-04-25 | 1998-06-09 | Wisconsin Alumni Research Foundation | Synthesis and use of β-lapachone analogs |
US6245807B1 (en) * | 1995-08-24 | 2001-06-12 | Dana-Farber Cancer Institute | Treatment of human prostate disease |
US5883270A (en) * | 1996-02-20 | 1999-03-16 | Wisconsin Alumni Research Foundation | 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth |
US5824700A (en) * | 1996-02-20 | 1998-10-20 | Wisconsin Alumni Research Foundation | Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth |
JP2002541200A (ja) * | 1999-04-14 | 2002-12-03 | デイナ−ファーバー キャンサー インスティチュート,インコーポレイテッド | 癌の処置のための方法および組成物 |
AU2003254029A1 (en) * | 2002-07-17 | 2004-02-02 | Arqule, Inc. | Activated checkpoint therapy and methods of use thereof |
-
2003
- 2003-11-18 WO PCT/US2003/037219 patent/WO2004045557A2/en active Application Filing
- 2003-11-18 MX MXPA05005314A patent/MXPA05005314A/es not_active Application Discontinuation
- 2003-11-18 EA EA200500849A patent/EA200500849A1/ru unknown
- 2003-11-18 EP EP03786941A patent/EP1567515A4/en active Pending
- 2003-11-18 JP JP2004553999A patent/JP2006508147A/ja active Pending
- 2003-11-18 CA CA002506340A patent/CA2506340A1/en not_active Abandoned
- 2003-11-18 BR BR0316296-6A patent/BR0316296A/pt not_active Application Discontinuation
- 2003-11-18 TW TW092132328A patent/TW200510367A/zh unknown
- 2003-11-18 AR ARP030104253A patent/AR056613A1/es not_active Application Discontinuation
- 2003-11-18 AU AU2003295738A patent/AU2003295738A1/en not_active Abandoned
- 2003-11-18 CN CNA2003801066171A patent/CN1729183A/zh active Pending
-
2004
- 2004-03-26 US US10/810,260 patent/US20040266857A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040266857A1 (en) | 2004-12-30 |
EA200500849A1 (ru) | 2006-02-24 |
EP1567515A2 (en) | 2005-08-31 |
CA2506340A1 (en) | 2004-06-03 |
TW200510367A (en) | 2005-03-16 |
BR0316296A (pt) | 2005-12-13 |
CN1729183A (zh) | 2006-02-01 |
WO2004045557A2 (en) | 2004-06-03 |
WO2004045557A3 (en) | 2004-08-12 |
EP1567515A4 (en) | 2008-04-23 |
JP2006508147A (ja) | 2006-03-09 |
MXPA05005314A (es) | 2005-10-19 |
AU2003295738A1 (en) | 2004-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |