BR0311593A - Derivados de 1-sulfonil-4-aminoalcoxi indol como moduladores de receptor 5-ht6 para tratamento dos distúrbios de snc - Google Patents
Derivados de 1-sulfonil-4-aminoalcoxi indol como moduladores de receptor 5-ht6 para tratamento dos distúrbios de sncInfo
- Publication number
- BR0311593A BR0311593A BR0311593-3A BR0311593A BR0311593A BR 0311593 A BR0311593 A BR 0311593A BR 0311593 A BR0311593 A BR 0311593A BR 0311593 A BR0311593 A BR 0311593A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- receptor modulators
- sulphonyl
- indole derivatives
- disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
"DERIVADOS DE 1-SULFONIL-4-AMINOALCOXI INDOL COMO MODULADORES DE RECEPTOR 5-HT6 PARA O TRATAMENTO DOS DISTúRBIOS DE SNC". A presente invenção refere-se a um composto de fórmula (I): um sal farmaceuticamente aceitável ou seu produto, no qual R^ 1^, R^ 2^, R^ 3^ , R^ 4^, R^ 5^, R^ 6^, e n são conforme definidos aqui. A presente invenção também refere-se a composições compreendendo métodos para seu uso, e métodos para preparação de compostos de fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38604902P | 2002-06-05 | 2002-06-05 | |
PCT/EP2003/005604 WO2003104193A1 (en) | 2002-06-05 | 2003-05-28 | 1-sulfonyl-4-aminoalkoxy indole derivatives as 5-ht6-receptor modulators for the treatment of cns-disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311593A true BR0311593A (pt) | 2005-04-26 |
Family
ID=29736132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311593-3A BR0311593A (pt) | 2002-06-05 | 2003-05-28 | Derivados de 1-sulfonil-4-aminoalcoxi indol como moduladores de receptor 5-ht6 para tratamento dos distúrbios de snc |
Country Status (13)
Country | Link |
---|---|
US (1) | US6774241B2 (pt) |
EP (1) | EP1513809A1 (pt) |
JP (1) | JP4390698B2 (pt) |
KR (1) | KR100657056B1 (pt) |
CN (1) | CN1293053C (pt) |
AR (1) | AR039957A1 (pt) |
AU (1) | AU2003237705B2 (pt) |
BR (1) | BR0311593A (pt) |
CA (1) | CA2485725A1 (pt) |
MX (1) | MXPA04012122A (pt) |
PL (1) | PL374401A1 (pt) |
RU (1) | RU2323927C2 (pt) |
WO (1) | WO2003104193A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL209872B1 (pl) | 2002-03-27 | 2011-10-31 | Glaxo Group Ltd | Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja |
BR0315317A (pt) | 2002-10-18 | 2005-09-06 | Hoffmann La Roche | 4-piperazinil benzenossulfonil indóis com afinidade para o receptor de 5-ht6 |
RS20060035A (en) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
SE0302760D0 (sv) * | 2003-10-20 | 2003-10-20 | Biovitrum Ab | New compounds |
US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
ES2359725T3 (es) | 2004-09-30 | 2011-05-26 | F. Hoffmann-La Roche Ag | Composiciones y métodos para el tratamiento de trastornos cognitivos. |
JP5091138B2 (ja) * | 2005-08-12 | 2012-12-05 | スヴェン・ライフ・サイエンシズ・リミテッド | 機能性5−ht6リガンドとしてのアミノアリールスルホンアミド誘導体 |
KR101250820B1 (ko) * | 2005-08-16 | 2013-04-04 | 수벤 라이프 사이언시스 리미티드 | 개선된 로사르탄 제조 방법 |
AU2007271188B2 (en) | 2006-07-03 | 2012-11-01 | Proximagen Limited | Indoles as 5-HT6 modulators |
EP2134714A1 (en) * | 2007-03-13 | 2009-12-23 | Biovitrum AB (publ) | Tricyclic isoquinoline derivatives for treatment of obesity |
KR20090123977A (ko) | 2007-03-23 | 2009-12-02 | 애보트 게엠베하 운트 콤파니 카게 | 세로토닌 5-ht6 수용체의 조절에 반응하는 장애를 치료하는데 적합한 아제티딘 화합물 |
RU2009139073A (ru) | 2007-03-23 | 2011-04-27 | Эбботт Гмбх Унд Ко.Кг (De) | Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-нт6 |
US8076491B2 (en) | 2007-08-21 | 2011-12-13 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
KR101599715B1 (ko) | 2007-08-21 | 2016-03-08 | 세노믹스, 인코포레이티드 | 인간 t2r 쓴맛 수용체 및 이의 용도 |
WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
CN102344402B (zh) * | 2010-07-30 | 2015-01-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯并氮杂环羟乙基胺类化合物、其制备方法和用途 |
JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 芳香族複素環式化合物及び医薬におけるその応用 |
CN105541693B (zh) | 2014-07-08 | 2018-10-16 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
CN109562085A (zh) | 2015-06-12 | 2019-04-02 | 阿速万科学有限责任公司 | 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物 |
AU2016291673A1 (en) | 2015-07-15 | 2018-01-25 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1139760A (en) | 1979-03-07 | 1983-01-18 | Makiko Sakai | 1,4-dioxaspiro¬4,5| decene compounds |
JPH04134064A (ja) | 1990-09-25 | 1992-05-07 | Otsuu Kenkyusho | 4―アルコキシインドール誘導体の製造方法 |
US5889022A (en) | 1993-12-21 | 1999-03-30 | Smithkline Beecham, P.L.C. | Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity |
JP2000501107A (ja) | 1996-01-09 | 2000-02-02 | イーライ・リリー・アンド・カンパニー | ベンズイミダゾリル神経ペプチドy受容体アンタゴニスト |
US5958965A (en) | 1996-08-27 | 1999-09-28 | American Home Products Corporation | 4-aminoethoxy indoles |
GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
MXPA03003397A (es) * | 2000-10-20 | 2004-06-30 | Biovitrum Ab | N1-(bencensulfonil)indoles sustituidos en las posiciones 2-, 3-, 4-, o 5 y su uso en terapia. |
EP1343756A2 (en) * | 2000-11-02 | 2003-09-17 | Wyeth | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
AU2002220715A1 (en) * | 2000-11-24 | 2002-06-03 | Smithkline Beecham Plc | Indolsulfonyl compounds useful in the treatment of cns disorders |
TW593278B (en) * | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
CN1293073C (zh) * | 2001-04-20 | 2007-01-03 | 惠氏公司 | 作为5-羟色胺-6配体的杂环基烷氧基-、-烷硫基-和-烷基氨基吲哚衍生物 |
BR0209056A (pt) * | 2001-04-20 | 2004-08-10 | Wyeth Corp | Derivados de heterociclilóxi-, -tióxi- e -aminobenzazol como ligantes de 5-hidroxitriptamina-6 |
-
2003
- 2003-05-28 BR BR0311593-3A patent/BR0311593A/pt not_active IP Right Cessation
- 2003-05-28 CN CNB038128489A patent/CN1293053C/zh not_active Expired - Fee Related
- 2003-05-28 JP JP2004511263A patent/JP4390698B2/ja not_active Expired - Fee Related
- 2003-05-28 PL PL03374401A patent/PL374401A1/xx not_active Application Discontinuation
- 2003-05-28 AU AU2003237705A patent/AU2003237705B2/en not_active Ceased
- 2003-05-28 MX MXPA04012122A patent/MXPA04012122A/es active IP Right Grant
- 2003-05-28 RU RU2004139050/04A patent/RU2323927C2/ru not_active IP Right Cessation
- 2003-05-28 KR KR1020047019737A patent/KR100657056B1/ko not_active IP Right Cessation
- 2003-05-28 EP EP03735482A patent/EP1513809A1/en not_active Withdrawn
- 2003-05-28 CA CA002485725A patent/CA2485725A1/en not_active Abandoned
- 2003-05-28 WO PCT/EP2003/005604 patent/WO2003104193A1/en active Application Filing
- 2003-06-04 US US10/454,050 patent/US6774241B2/en not_active Expired - Fee Related
- 2003-06-04 AR ARP030101981A patent/AR039957A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US6774241B2 (en) | 2004-08-10 |
PL374401A1 (en) | 2005-10-17 |
AU2003237705B2 (en) | 2009-07-30 |
KR100657056B1 (ko) | 2006-12-13 |
CN1659141A (zh) | 2005-08-24 |
CN1293053C (zh) | 2007-01-03 |
RU2323927C2 (ru) | 2008-05-10 |
CA2485725A1 (en) | 2003-12-18 |
US20030229069A1 (en) | 2003-12-11 |
EP1513809A1 (en) | 2005-03-16 |
WO2003104193A1 (en) | 2003-12-18 |
JP2005533048A (ja) | 2005-11-04 |
AU2003237705A1 (en) | 2003-12-22 |
MXPA04012122A (es) | 2005-04-19 |
KR20050010861A (ko) | 2005-01-28 |
AR039957A1 (es) | 2005-03-09 |
JP4390698B2 (ja) | 2009-12-24 |
RU2004139050A (ru) | 2005-09-10 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2157 DE 08/05/2012. |