AR016036A1 - Derivados de tetrahidroisoquinolina, un procedimiento para su preparacion, una composicion farmaceutica y el uso de los mismos para la fabricacion de unmedicamento - Google Patents
Derivados de tetrahidroisoquinolina, un procedimiento para su preparacion, una composicion farmaceutica y el uso de los mismos para la fabricacion de unmedicamentoInfo
- Publication number
- AR016036A1 AR016036A1 ARP990102365A ARP990102365A AR016036A1 AR 016036 A1 AR016036 A1 AR 016036A1 AR P990102365 A ARP990102365 A AR P990102365A AR P990102365 A ARP990102365 A AR P990102365A AR 016036 A1 AR016036 A1 AR 016036A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- group
- alkoxy
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Derivados de tetrahidroisoquinolina de formula (I): en la cual R1 representa un sustituyente seleccionado de: un átomo de hidrogeno o halogeno; un grupohidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, trifluorometanosulfoniloxi, pentafluoretilo, alquilo C1-4, aril-alcoxi C1-4, alquitio C1-4, alcoxiC1-4-alquilo C1-4, cicloalquil C3-6-alcoxi C1-4, alcanoílo C1-4, alcoxi C1-4-carbonilo, alquilsulfonilo C1-4, alquilsulfoniloxi C1-4, alquilsulfonil C1-4-alquilo C1-4, arilsulfonilo, arilsulfoniloxi, arilsulfonilalquilo C1-4, alquilsulfonamido C1-4, alquil C1-4-amido, alquilsulfonamido C1-4-alquilo C1-4, alquilC1-4-amido-alquilo C1-4, aril-sulfonamido, arilcarboxamido, arilsulfonamido-alquilo C1-4, arilcarboxamido-alquilo C1-4, aroílo, aroilalquilo C1-4, oaril-alcanoílo C1-4; un grupo R3OCO(CH2)p, R3CON(R4)(CH2)p, R3R4NCO(CH2)p o R3R4NSO2(CH2)p donde cada uno de R3 y R4 representa independientemente un átomo dehidrogeno o un grupo alquilo C1-4, o R3R4 forma parte de un anillo de azacicloalcano C3-6 o (2-oxo)azacicloalcano C3-6 y p representa cero o un numero enterode 1 a 4; o un grupo Ar1-Z, en el cual Ar1 representa un anillo de fenilo opcionalmente sustituido o un anillo aromático heterocíclico de 5 o 6 miembrosopcionalmente sustituido y Z representa un enlace, O, S, o CH2; R2 representa un átomo de hidrogeno o un grupo alquilo C1-4; q es 1 o 2; A representa un grupode la formula: -(CH2)r-V-(CH2)s-Ar en la cual r y s representan independientemente un numero entero de 0 a 3tal que la suma de r y s es igual a un numeroentero de 1 a 4; V representa un enlace, O o S; Ar representa un anillo de fenilo opcionalmente sustituido o un anillo aromático heterocíclico de 5 o 6miembros opcionalmente sustituido; o un sistema de anillos bicíclico opcionalmente sustituido; y sus sales. Los compuestos son utiles para el tratamiento decondiciones que requieren modulacion de un receptor de dopamina, tales como esquizofrenia. Además, se describe un procedimiento para su preparacion, unacomposicion farmacéutica y el uso de los mismos para la fabricacion de un medicamento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9810876.4A GB9810876D0 (en) | 1998-05-20 | 1998-05-20 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016036A1 true AR016036A1 (es) | 2001-05-30 |
Family
ID=10832418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102365A AR016036A1 (es) | 1998-05-20 | 1999-05-18 | Derivados de tetrahidroisoquinolina, un procedimiento para su preparacion, una composicion farmaceutica y el uso de los mismos para la fabricacion de unmedicamento |
Country Status (9)
Country | Link |
---|---|
US (1) | US6414154B1 (es) |
EP (1) | EP1086084A1 (es) |
JP (1) | JP2002515489A (es) |
AR (1) | AR016036A1 (es) |
AU (1) | AU4262799A (es) |
CA (1) | CA2332316A1 (es) |
CO (1) | CO5031252A1 (es) |
GB (1) | GB9810876D0 (es) |
WO (1) | WO1999059974A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69929704T2 (de) | 1998-10-08 | 2006-07-20 | Smithkline Beecham Plc, Brentford | Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) |
HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
US7589207B2 (en) | 2002-12-13 | 2009-09-15 | Smithkline Beecham Corporation | Cyclohexyl compounds as CCR5 antagonists |
US10870660B2 (en) | 2016-07-28 | 2020-12-22 | Shionogi & Co., Ltd. | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect |
JPWO2019146739A1 (ja) * | 2018-01-26 | 2021-01-07 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する縮環化合物 |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA792785B (en) | 1978-07-07 | 1980-08-27 | Smithkline Corp | Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines |
US4220778A (en) | 1978-10-30 | 1980-09-02 | G. D. Searle & Co. | 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof |
IL63918A0 (en) | 1980-10-17 | 1981-12-31 | Pennwalt Corp | N-(amino(or hydroxy)phenethyl)-1,2,3,4-tetrahydroisoquinolines,their preparation and pharmaceutical compositions containing them |
ZA816903B (en) | 1980-10-17 | 1983-02-23 | Pennwalt Corp | N-(amino(or hydroxy)-1,2,3,4,-tetrahydroisoquinolines, precursors thereof, and methods of preparation |
FR2618149B1 (fr) | 1987-07-16 | 1989-09-22 | Synthelabo | Derives de n-aminoalkyl n-phenyl arylamides, leur preparation et leur application en therapeutique |
IL89156A (en) | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
US5217977A (en) | 1989-02-28 | 1993-06-08 | Imperial Chemical Industries Plc | Heterocyclic cycloalkanes |
US5047406A (en) | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
JP2800953B2 (ja) | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
US5633376A (en) | 1990-12-28 | 1997-05-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands |
WO1992012132A1 (en) | 1991-01-11 | 1992-07-23 | Laboratoires Glaxo S.A. | Acridine derivatives |
WO1993003025A1 (fr) | 1991-08-09 | 1993-02-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thiophene |
EP0596125A4 (en) | 1991-12-26 | 1994-10-05 | Yoshitomi Pharmaceutical | Condensed thiophene compound and pharmaceutical use thereof. |
US5532240A (en) | 1991-12-26 | 1996-07-02 | Yoshitomi Pharmaceutical Industries, Ltd. | Condensed thiophene compound and pharmaceutical use thereof |
GB9206757D0 (en) | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
EP0649410B1 (en) | 1992-07-10 | 1997-05-02 | Laboratoires Glaxo Sa | Anilide derivatives |
KR950702962A (ko) | 1992-08-06 | 1995-08-23 | 데이비드 로버츠 | 도파민 D₃수용체 길항제인 5-(2-옥시페닐)-피롤 유도체(5-(2-Oxyphenyl)-Pyrrole Derivatives as Dopamine D₃Receptor Antagonists) |
US5294621A (en) * | 1992-10-07 | 1994-03-15 | Ortho Pharmaceutical Corporation | Thieno tetrahydropyridines useful as class III antiarrhythmic agents |
GB9305644D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
GB9307400D0 (en) | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
JP2959615B2 (ja) | 1993-06-24 | 1999-10-06 | 吉富製薬株式会社 | 縮合型チオフェン化合物およびその医薬用途 |
WO1995000508A1 (en) | 1993-06-25 | 1995-01-05 | Smithkline Beecham Plc | Phenyrrole derivatives and their use as dopamine d3 antagonists |
GB9315801D0 (en) | 1993-07-30 | 1993-09-15 | Smithkline Beecham Plc | Compounds |
HUT75876A (en) | 1993-08-12 | 1997-05-28 | Astra Ab | Amidine derivatives with nitric oxide synthetase activities, pharmaceutical compositions containing them and process for their preparation |
GB9320855D0 (en) | 1993-10-09 | 1993-12-01 | Smithkline Beecham Plc | Compounds |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
GB9325827D0 (en) | 1993-12-17 | 1994-02-23 | Smithkline Beecham Plc | Compounds |
GB9402197D0 (en) | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
GB9402807D0 (en) | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
GB9403199D0 (en) | 1994-02-19 | 1994-04-13 | Smithkline Beecham Plc | Compounds |
CA2187429A1 (en) | 1994-04-28 | 1995-11-09 | Junya Ohmori | N-(3-pyrrolidinyl)benzamide derivative |
US5414010A (en) | 1994-05-10 | 1995-05-09 | Warner-Lambert Company | Dimeric benzimidazoles as central nervous system agents |
DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
GB9418912D0 (en) | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
WO1996011007A1 (en) | 1994-10-05 | 1996-04-18 | Glaxo Wellcome Inc. | Parenteral pharmaceutical compositions containing gf120918a |
US5478934A (en) | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
GB9426071D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB9426090D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
GB9426224D0 (en) | 1994-12-23 | 1995-02-22 | Xenova Ltd | Pharmaceutical compounds |
US5891877A (en) | 1995-02-14 | 1999-04-06 | Xenova Limited | Pharmaceutical compounds |
EP0809641A1 (en) | 1995-02-15 | 1997-12-03 | Neurogen Corporation | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands |
GB9512129D0 (en) | 1995-06-15 | 1995-08-16 | Smithkline Beecham Plc | Compounds |
AU6859096A (en) | 1995-09-22 | 1997-04-09 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous system agents |
FR2741074B1 (fr) | 1995-11-09 | 1997-12-19 | Adir | Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
WO1997028166A1 (de) | 1996-02-01 | 1997-08-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienochinoline |
AU1618697A (en) | 1996-02-06 | 1997-08-28 | Japan Tobacco Inc. | Novel compounds and pharmaceutical use thereof |
JPH09291034A (ja) | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
US5710274A (en) | 1996-02-28 | 1998-01-20 | Neurogen Corporation | N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands |
US5763609A (en) | 1996-03-21 | 1998-06-09 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands |
US5703237A (en) | 1996-04-18 | 1997-12-30 | Neurogen Corporation | N-Aminoalkyl-2-anthraquinonecarboxamides; new dopamine receptor subtype specific ligands |
US5688950A (en) | 1996-04-23 | 1997-11-18 | Neurogen Corporation | Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands |
NZ332477A (en) * | 1996-05-11 | 2000-07-28 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptors |
CA2263284A1 (en) * | 1996-08-14 | 1998-02-19 | Smithkline Beecham P.L.C. | Tetrahydroisoquinoline derivatives and their pharmaceutical use |
WO1998007421A1 (fr) | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
WO1998023593A1 (en) | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
FR2761985B1 (fr) | 1997-04-10 | 1999-05-21 | Adir | Nouveaux composes amines du 6,7,8,9-tetrahydro-cyclopenta[a] naphtalene et du 2,3-dihydro-cyclopenta[e]indene, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO1998048784A2 (en) | 1997-04-28 | 1998-11-05 | The University Of British Columbia | Method and composition for modulating amyloidosis |
GB9708694D0 (en) | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
WO1998050364A1 (en) * | 1997-05-03 | 1998-11-12 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
GB9709303D0 (en) | 1997-05-09 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
GB9710612D0 (en) | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
GB9812522D0 (en) | 1998-06-10 | 1998-08-05 | Smithkline Beecham Plc | Compounds |
GB9821977D0 (en) | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
GB9821978D0 (en) | 1998-10-08 | 1998-12-02 | Smithkline Beecham Plc | Compounds |
DE69929704T2 (de) | 1998-10-08 | 2006-07-20 | Smithkline Beecham Plc, Brentford | Tetrahydrobenzazepin-derivate verwendbar als dopamin-d3-rezeptor-modulatoren (antipsychotische mittel) |
AR022230A1 (es) | 1999-01-12 | 2002-09-04 | Abbott Gmbh & Co Kg | Compuestos de triazol, composicion farmaceutica que los comprende y uso de los mismos para preparar dicha composicion |
-
1998
- 1998-05-20 GB GBGB9810876.4A patent/GB9810876D0/en not_active Ceased
-
1999
- 1999-05-14 US US09/700,775 patent/US6414154B1/en not_active Expired - Fee Related
- 1999-05-14 EP EP99952090A patent/EP1086084A1/en not_active Withdrawn
- 1999-05-14 AU AU42627/99A patent/AU4262799A/en not_active Abandoned
- 1999-05-14 WO PCT/EP1999/003371 patent/WO1999059974A1/en not_active Application Discontinuation
- 1999-05-14 JP JP2000549593A patent/JP2002515489A/ja active Pending
- 1999-05-14 CA CA002332316A patent/CA2332316A1/en not_active Abandoned
- 1999-05-18 AR ARP990102365A patent/AR016036A1/es unknown
- 1999-05-19 CO CO99030532A patent/CO5031252A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO5031252A1 (es) | 2001-04-27 |
GB9810876D0 (en) | 1998-07-22 |
JP2002515489A (ja) | 2002-05-28 |
WO1999059974A1 (en) | 1999-11-25 |
US6414154B1 (en) | 2002-07-02 |
AU4262799A (en) | 1999-12-06 |
EP1086084A1 (en) | 2001-03-28 |
CA2332316A1 (en) | 1999-11-25 |
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