HUP0203332A2 - Ciklotiokarbamát-származékok, progeszteron receptor modulátorokként való alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Ciklotiokarbamát-származékok, progeszteron receptor modulátorokként való alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0203332A2 HUP0203332A2 HU0203332A HUP0203332A HUP0203332A2 HU P0203332 A2 HUP0203332 A2 HU P0203332A2 HU 0203332 A HU0203332 A HU 0203332A HU P0203332 A HUP0203332 A HU P0203332A HU P0203332 A2 HUP0203332 A2 HU P0203332A2
- Authority
- HU
- Hungary
- Prior art keywords
- optionally substituted
- substituted alkyl
- group
- aryl
- hydrogen atom
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002379 progesterone receptor modulator Substances 0.000 title 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 7
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 229960003387 progesterone Drugs 0.000 abstract 2
- 239000000186 progesterone Substances 0.000 abstract 2
- 241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány (I) és (II) általános képletű vegyületekre ésfarmakológiailag elfogadható sóikra vonatkozik, amelyek progeszteronagonista aktivitással rendelkeznek, így fogamzásgátlóként és olyanállapotok kezelésére alkalmazhatók, amelyekben a progeszteron szerepetjátszik. A képletekben R1 és R2 jelentése hidrogénatom, adott esetbenszubsztituált alkil-, alkenil-, alkinil-, cikloalkil-, aril-,heterociklusos csoport, amelyek adott esetben szubsztituálva lehetnek,továbbá CORA vagy NRBCORA általános képletű csoport, vagy pedig R1 ésR2 együttesen egy spirociklusos gyűrűt képeznek, amelyek adott esetben1-3-szorosan helyettesítve lehetnek, RA és RB jelentése hidrogénatomvagy adott esetben szubsztituált alkil-, alkoxi-, amino- vagyaminoalkilcsoport, R3 jelentése hidrogénatom, hidroxil-, amino- vagyadott esetben szubsztituált alkil-, alkenil-, alkinilcsoport vagy CORáltalános képletű csoport, Rc jelentése hidrogénatom, adott esetbenszubsztituált alkil-, aril-, alkoxi- vagy aminoalkilcsoport, R4jelentése hidrogén- vagy halogénatom, ciano-, nitro- vagy adottesetben szubsztituált alkil-, alkoxi- vagy aminoalkilcsoport, R5jelentése adott esetben szubsztituált benzol- vagy heterociklusosgyűrű, Q1 és Q2 jelentése kénatom, NR7 vagy CR8R9 általános képletűcsoport, R7, R8 és R9 jelentése hidrogénatom, ciano- vagy adottesetben szubsztituált alkil-, cikloalkil-, aril- vagy heterociklusoscsoport vagy SO2CF3, OR11 vagy NR11R12 általános képletű csoport, R11és R12 jelentése hidrogénatom vagy adott esetben szubsztituált alkil-,aril-, heteroaril-, acil- vagy szulfonilcsoport. A találmány kiterjeda vegyületeket tartalmazó gyógyszerkészítményekre is. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18301399P | 1999-05-04 | 1999-05-04 | |
| US09/552,354 US6436929B1 (en) | 1999-05-04 | 2000-04-19 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
| PCT/US2000/011749 WO2000066570A1 (en) | 1999-05-04 | 2000-05-01 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0203332A2 true HUP0203332A2 (hu) | 2003-01-28 |
| HUP0203332A3 HUP0203332A3 (en) | 2004-12-28 |
Family
ID=26878649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0203332A HUP0203332A3 (en) | 1999-05-04 | 2000-05-01 | Cyclothiocarbamate derivatives, their use as progesterone receptor modulators and pharmaceutical compositions containing them |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1175411B1 (hu) |
| JP (2) | JP4958338B2 (hu) |
| KR (1) | KR100732692B1 (hu) |
| CN (1) | CN1131856C (hu) |
| AT (1) | ATE386729T1 (hu) |
| AU (1) | AU766801B2 (hu) |
| BG (1) | BG65277B1 (hu) |
| BR (1) | BR0010214A (hu) |
| CA (1) | CA2371712C (hu) |
| CZ (1) | CZ20013952A3 (hu) |
| DE (1) | DE60038108T2 (hu) |
| DK (1) | DK1175411T3 (hu) |
| EA (1) | EA004511B1 (hu) |
| ES (1) | ES2301482T3 (hu) |
| GE (1) | GEP20043181B (hu) |
| HU (1) | HUP0203332A3 (hu) |
| IL (1) | IL146298A0 (hu) |
| MX (1) | MXPA01011287A (hu) |
| NO (1) | NO321370B1 (hu) |
| NZ (1) | NZ515353A (hu) |
| PL (1) | PL351083A1 (hu) |
| SG (1) | SG120970A1 (hu) |
| SK (1) | SK15922001A3 (hu) |
| TR (1) | TR200103285T2 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0203332A3 (en) * | 1999-05-04 | 2004-12-28 | Wyeth Corp | Cyclothiocarbamate derivatives, their use as progesterone receptor modulators and pharmaceutical compositions containing them |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| PL1732922T3 (pl) * | 2004-04-08 | 2009-03-31 | Wyeth Corp | Sposób minimalizowania zanieczyszczeń tioamidowych |
| EP1732921B1 (en) * | 2004-04-08 | 2008-11-05 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
| JP5039541B2 (ja) * | 2004-04-27 | 2012-10-03 | ワイス・エルエルシー | プロゲステロン受容体調節剤の精製 |
| BRPI0510278A (pt) * | 2004-04-27 | 2007-10-30 | Wyeth Corp | método para produzir compostos, produto, e, composto |
| PE20060378A1 (es) * | 2004-07-07 | 2006-06-02 | Wyeth Corp | Regimenes y kits de progestina ciclica |
| WO2006020712A1 (en) * | 2004-08-13 | 2006-02-23 | Wyeth | Tanaproget derivatives, metabolites, and uses thereof |
| WO2006116596A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget and compostions containing same |
| MX2007013469A (es) * | 2005-04-28 | 2008-01-22 | Wyeth Corp | Forma ii polimorfa de tanaproget. |
| JP2008539254A (ja) * | 2005-04-28 | 2008-11-13 | ワイス | タナプロゲットの精製形態 |
| WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| WO2006116514A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget, compositions, and methods of preparing the same |
| CN101193639A (zh) * | 2005-06-09 | 2008-06-04 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
| JPH0510235A (ja) * | 1991-07-05 | 1993-01-19 | Nippondenso Co Ltd | 内燃機関の点火時期制御装置 |
| WO1995020389A1 (en) * | 1994-01-28 | 1995-08-03 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
| PT800519E (pt) * | 1994-12-22 | 2004-03-31 | Ligand Pharm Inc | Compostos moduladores de receptores de esteroides e metodos |
| US5696130A (en) * | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
| WO1998014436A1 (en) * | 1996-10-02 | 1998-04-09 | Dupont Pharmaceuticals Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same |
| HUP0203332A3 (en) * | 1999-05-04 | 2004-12-28 | Wyeth Corp | Cyclothiocarbamate derivatives, their use as progesterone receptor modulators and pharmaceutical compositions containing them |
| WO2006116596A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget and compostions containing same |
| CN101193639A (zh) * | 2005-06-09 | 2008-06-04 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
-
2000
- 2000-05-01 HU HU0203332A patent/HUP0203332A3/hu unknown
- 2000-05-01 SK SK1592-2001A patent/SK15922001A3/sk unknown
- 2000-05-01 BR BR0010214-8A patent/BR0010214A/pt active Search and Examination
- 2000-05-01 TR TR2001/03285T patent/TR200103285T2/xx unknown
- 2000-05-01 SG SG200400081A patent/SG120970A1/en unknown
- 2000-05-01 MX MXPA01011287A patent/MXPA01011287A/es active IP Right Grant
- 2000-05-01 CZ CZ20013952A patent/CZ20013952A3/cs unknown
- 2000-05-01 AU AU48119/00A patent/AU766801B2/en not_active Ceased
- 2000-05-01 ES ES00930266T patent/ES2301482T3/es not_active Expired - Lifetime
- 2000-05-01 DE DE60038108T patent/DE60038108T2/de not_active Expired - Lifetime
- 2000-05-01 EP EP00930266A patent/EP1175411B1/en not_active Expired - Lifetime
- 2000-05-01 KR KR1020017014085A patent/KR100732692B1/ko not_active IP Right Cessation
- 2000-05-01 AT AT00930266T patent/ATE386729T1/de not_active IP Right Cessation
- 2000-05-01 CA CA002371712A patent/CA2371712C/en not_active Expired - Fee Related
- 2000-05-01 JP JP2000615600A patent/JP4958338B2/ja not_active Expired - Fee Related
- 2000-05-01 GE GEAP20006120A patent/GEP20043181B/en unknown
- 2000-05-01 DK DK00930266T patent/DK1175411T3/da active
- 2000-05-01 EA EA200101181A patent/EA004511B1/ru not_active IP Right Cessation
- 2000-05-01 CN CN008070997A patent/CN1131856C/zh not_active Expired - Fee Related
- 2000-05-01 NZ NZ515353A patent/NZ515353A/xx unknown
- 2000-05-01 PL PL00351083A patent/PL351083A1/xx not_active Application Discontinuation
- 2000-05-01 IL IL14629800A patent/IL146298A0/xx unknown
-
2001
- 2001-11-02 BG BG106080A patent/BG65277B1/bg unknown
- 2001-11-02 NO NO20015381A patent/NO321370B1/no unknown
-
2011
- 2011-11-14 JP JP2011249051A patent/JP5523430B2/ja not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: WYETH, US Free format text: FORMER OWNER(S): AMERICAN HOME PRODUCTS CO., US; LIGAND PHARMACEUTICALS, INC., US; WYETH, US |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |