CN1131856C - 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 - Google Patents
作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 Download PDFInfo
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- CN1131856C CN1131856C CN008070997A CN00807099A CN1131856C CN 1131856 C CN1131856 C CN 1131856C CN 008070997 A CN008070997 A CN 008070997A CN 00807099 A CN00807099 A CN 00807099A CN 1131856 C CN1131856 C CN 1131856C
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- Prior art keywords
- dihydro
- dimethyl
- benzoxazine
- alkyl
- sulfo
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- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 102000005969 steroid hormone receptors Human genes 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- MFPWEWYKQYMWRO-UHFFFAOYSA-N tert-butyl carboxy carbonate Chemical compound CC(C)(C)OC(=O)OC(O)=O MFPWEWYKQYMWRO-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- ZCAGUOCUDGWENZ-UHFFFAOYSA-N thiomorpholinyl sulfoxide group Chemical group N1(CCSCC1)S(=O)N1CCSCC1 ZCAGUOCUDGWENZ-UHFFFAOYSA-N 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
- PNQBEPDZQUOCNY-UHFFFAOYSA-N trifluoroacetyl chloride Chemical compound FC(F)(F)C(Cl)=O PNQBEPDZQUOCNY-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 208000012991 uterine carcinoma Diseases 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000005186 women's health Effects 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- GTLDTDOJJJZVBW-UHFFFAOYSA-N zinc cyanide Chemical compound [Zn+2].N#[C-].N#[C-] GTLDTDOJJJZVBW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (9)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18301399P | 1999-05-04 | 1999-05-04 | |
US60/183,013 | 1999-05-04 | ||
US09/552,354 US6436929B1 (en) | 1999-05-04 | 2000-04-19 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
US09/552,354 | 2000-04-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1349516A CN1349516A (zh) | 2002-05-15 |
CN1131856C true CN1131856C (zh) | 2003-12-24 |
Family
ID=26878649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN008070997A Expired - Fee Related CN1131856C (zh) | 1999-05-04 | 2000-05-01 | 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1175411B1 (zh) |
JP (2) | JP4958338B2 (zh) |
KR (1) | KR100732692B1 (zh) |
CN (1) | CN1131856C (zh) |
AT (1) | ATE386729T1 (zh) |
AU (1) | AU766801B2 (zh) |
BG (1) | BG65277B1 (zh) |
BR (1) | BR0010214A (zh) |
CA (1) | CA2371712C (zh) |
CZ (1) | CZ20013952A3 (zh) |
DE (1) | DE60038108T2 (zh) |
DK (1) | DK1175411T3 (zh) |
EA (1) | EA004511B1 (zh) |
ES (1) | ES2301482T3 (zh) |
GE (1) | GEP20043181B (zh) |
HU (1) | HUP0203332A3 (zh) |
IL (1) | IL146298A0 (zh) |
MX (1) | MXPA01011287A (zh) |
NO (1) | NO321370B1 (zh) |
NZ (1) | NZ515353A (zh) |
PL (1) | PL351083A1 (zh) |
SG (1) | SG120970A1 (zh) |
SK (1) | SK15922001A3 (zh) |
TR (1) | TR200103285T2 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101001863B (zh) * | 2004-08-13 | 2012-10-10 | 惠氏公司 | 坦普盖特衍生物、代谢物及其用途 |
CN104208067A (zh) * | 2004-07-07 | 2014-12-17 | 惠氏公司 | 周期性黄体酮方案及试剂盒 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0203332A3 (en) * | 1999-05-04 | 2004-12-28 | Wyeth Corp | Cyclothiocarbamate derivatives, their use as progesterone receptor modulators and pharmaceutical compositions containing them |
US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
PL1732922T3 (pl) * | 2004-04-08 | 2009-03-31 | Wyeth Corp | Sposób minimalizowania zanieczyszczeń tioamidowych |
EP1732921B1 (en) * | 2004-04-08 | 2008-11-05 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
JP5039541B2 (ja) * | 2004-04-27 | 2012-10-03 | ワイス・エルエルシー | プロゲステロン受容体調節剤の精製 |
BRPI0510278A (pt) * | 2004-04-27 | 2007-10-30 | Wyeth Corp | método para produzir compostos, produto, e, composto |
WO2006116596A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget and compostions containing same |
MX2007013469A (es) * | 2005-04-28 | 2008-01-22 | Wyeth Corp | Forma ii polimorfa de tanaproget. |
JP2008539254A (ja) * | 2005-04-28 | 2008-11-13 | ワイス | タナプロゲットの精製形態 |
WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
WO2006116514A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget, compositions, and methods of preparing the same |
CN101193639A (zh) * | 2005-06-09 | 2008-06-04 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
JPH0510235A (ja) * | 1991-07-05 | 1993-01-19 | Nippondenso Co Ltd | 内燃機関の点火時期制御装置 |
WO1995020389A1 (en) * | 1994-01-28 | 1995-08-03 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
PT800519E (pt) * | 1994-12-22 | 2004-03-31 | Ligand Pharm Inc | Compostos moduladores de receptores de esteroides e metodos |
US5696130A (en) * | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
WO1998014436A1 (en) * | 1996-10-02 | 1998-04-09 | Dupont Pharmaceuticals Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same |
HUP0203332A3 (en) * | 1999-05-04 | 2004-12-28 | Wyeth Corp | Cyclothiocarbamate derivatives, their use as progesterone receptor modulators and pharmaceutical compositions containing them |
WO2006116596A2 (en) * | 2005-04-28 | 2006-11-02 | Wyeth | Micronized tanaproget and compostions containing same |
CN101193639A (zh) * | 2005-06-09 | 2008-06-04 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
-
2000
- 2000-05-01 HU HU0203332A patent/HUP0203332A3/hu unknown
- 2000-05-01 SK SK1592-2001A patent/SK15922001A3/sk unknown
- 2000-05-01 BR BR0010214-8A patent/BR0010214A/pt active Search and Examination
- 2000-05-01 TR TR2001/03285T patent/TR200103285T2/xx unknown
- 2000-05-01 SG SG200400081A patent/SG120970A1/en unknown
- 2000-05-01 MX MXPA01011287A patent/MXPA01011287A/es active IP Right Grant
- 2000-05-01 CZ CZ20013952A patent/CZ20013952A3/cs unknown
- 2000-05-01 AU AU48119/00A patent/AU766801B2/en not_active Ceased
- 2000-05-01 ES ES00930266T patent/ES2301482T3/es not_active Expired - Lifetime
- 2000-05-01 DE DE60038108T patent/DE60038108T2/de not_active Expired - Lifetime
- 2000-05-01 EP EP00930266A patent/EP1175411B1/en not_active Expired - Lifetime
- 2000-05-01 KR KR1020017014085A patent/KR100732692B1/ko not_active IP Right Cessation
- 2000-05-01 AT AT00930266T patent/ATE386729T1/de not_active IP Right Cessation
- 2000-05-01 CA CA002371712A patent/CA2371712C/en not_active Expired - Fee Related
- 2000-05-01 JP JP2000615600A patent/JP4958338B2/ja not_active Expired - Fee Related
- 2000-05-01 GE GEAP20006120A patent/GEP20043181B/en unknown
- 2000-05-01 DK DK00930266T patent/DK1175411T3/da active
- 2000-05-01 EA EA200101181A patent/EA004511B1/ru not_active IP Right Cessation
- 2000-05-01 CN CN008070997A patent/CN1131856C/zh not_active Expired - Fee Related
- 2000-05-01 NZ NZ515353A patent/NZ515353A/xx unknown
- 2000-05-01 PL PL00351083A patent/PL351083A1/xx not_active Application Discontinuation
- 2000-05-01 IL IL14629800A patent/IL146298A0/xx unknown
-
2001
- 2001-11-02 BG BG106080A patent/BG65277B1/bg unknown
- 2001-11-02 NO NO20015381A patent/NO321370B1/no unknown
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2011
- 2011-11-14 JP JP2011249051A patent/JP5523430B2/ja not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104208067A (zh) * | 2004-07-07 | 2014-12-17 | 惠氏公司 | 周期性黄体酮方案及试剂盒 |
CN101001863B (zh) * | 2004-08-13 | 2012-10-10 | 惠氏公司 | 坦普盖特衍生物、代谢物及其用途 |
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Address after: new jersey Co-patentee after: Ligand Pharmaceuticals, Inc. Patentee after: Wyeth Corp. Address before: new jersey Co-patentee before: Ligand Pharmaceuticals, Inc. Patentee before: American Home Products Corp. |
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