ATE225784T1 - Indan- oder dihydroindolderivate - Google Patents

Indan- oder dihydroindolderivate

Info

Publication number
ATE225784T1
ATE225784T1 AT97949998T AT97949998T ATE225784T1 AT E225784 T1 ATE225784 T1 AT E225784T1 AT 97949998 T AT97949998 T AT 97949998T AT 97949998 T AT97949998 T AT 97949998T AT E225784 T1 ATE225784 T1 AT E225784T1
Authority
AT
Austria
Prior art keywords
indaneous
dihydroindole derivatives
dihydroindole
derivatives
Prior art date
Application number
AT97949998T
Other languages
English (en)
Inventor
Jens Kristian Perregaard
Benny Bang-Andersen
Henrik Pedersen
Ivan Mikkelsen
Robert Dancer
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE225784T1 publication Critical patent/ATE225784T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C5/00—Details of stores covered by group G11C11/00
    • G11C5/02—Disposition of storage elements, e.g. in the form of a matrix array
    • G11C5/025—Geometric lay-out considerations of storage- and peripheral-blocks in a semiconductor storage device
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
    • G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
    • G11C7/1048—Data bus control circuits, e.g. precharging, presetting, equalising

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT97949998T 1996-12-20 1997-12-19 Indan- oder dihydroindolderivate ATE225784T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK151496 1996-12-20
PCT/DK1997/000587 WO1998028293A1 (en) 1996-12-20 1997-12-19 Indane or dihydroindole derivatives

Publications (1)

Publication Number Publication Date
ATE225784T1 true ATE225784T1 (de) 2002-10-15

Family

ID=8105631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97949998T ATE225784T1 (de) 1996-12-20 1997-12-19 Indan- oder dihydroindolderivate

Country Status (28)

Country Link
US (3) US6262087B1 (de)
EP (1) EP0946542B1 (de)
JP (1) JP3251300B2 (de)
KR (1) KR100432297B1 (de)
CN (3) CN1244558C (de)
AR (1) AR008545A1 (de)
AT (1) ATE225784T1 (de)
AU (1) AU731243B2 (de)
BG (1) BG63968B1 (de)
BR (1) BR9714039A (de)
CZ (1) CZ297416B6 (de)
DE (1) DE69716296T2 (de)
DK (1) DK0946542T3 (de)
EA (1) EA002158B1 (de)
ES (1) ES2185058T3 (de)
HK (1) HK1025775A1 (de)
HU (1) HUP0000079A3 (de)
IL (1) IL130133A (de)
IS (1) IS2018B (de)
NO (2) NO318978B1 (de)
NZ (1) NZ335973A (de)
PL (1) PL188418B1 (de)
PT (1) PT946542E (de)
SK (1) SK283678B6 (de)
TR (1) TR199901407T2 (de)
UA (1) UA66778C2 (de)
WO (1) WO1998028293A1 (de)
ZA (1) ZA9711376B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
ES2188155T3 (es) * 1998-04-08 2003-06-16 Wyeth Corp N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.
TW528754B (en) * 1998-04-29 2003-04-21 Wyeth Corp Indolyl derivatibes as serotonergic agents
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
EP1085890A1 (de) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Neuartige natriumkanal-medikamente und deren verwendungen
US6541669B1 (en) * 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
AU4425399A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors
CA2335711A1 (en) * 1998-06-19 1999-12-29 Ivan Mikkelsen 4,5,6 and 7-indole and indoline derivatives, their preparation and use
ID27976A (id) 1998-06-19 2001-05-03 Lundbeck & Co As H 4,5,6 dan 7-indol dan turunan-turunan indolin, pembuatan dan penggunaannya
AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2000069424A2 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
WO2000076967A1 (en) * 1999-06-14 2000-12-21 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
US6355644B1 (en) 1999-06-14 2002-03-12 Neurogen Corporation Benzylpiperazinyl-indolinylethanones
CA2341542A1 (en) * 1999-06-24 2000-12-28 Toray Industries, Inc. .alpha.1b-adrenergic receptor antagonists
PL201178B1 (pl) 1999-08-23 2009-03-31 Solvay Pharm Bv Nowe pochodne fenylopiperazyny, sposób ich wytwarzania, kompozycja farmaceutyczna oraz zastosowanie
WO2001043740A1 (en) 1999-12-17 2001-06-21 Bristol-Myers Squibb Company Antipsychotic heterocycle compounds
CN100415737C (zh) * 2000-06-14 2008-09-03 H·隆德贝克有限公司 用于治疗cns疾病的吲哚衍生物
DK1294710T3 (da) * 2000-06-14 2005-10-03 Lundbeck & Co As H Indolderivater, der er egnede til behandlingen af CNS-lidelser
AR028685A1 (es) * 2000-06-14 2003-05-21 Lundbeck & Co As H Derivados de indol
CA2414115A1 (en) * 2000-06-29 2002-01-03 Jakob Felding Indole derivatives useful for the treatment of cns disorders
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR033287A1 (es) * 2001-05-09 2003-12-10 Lundbeck & Co As H Tratamiento del adhd
WO2003080050A1 (en) * 2002-03-27 2003-10-02 H. Lundbeck A/S The use of 3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]-6-chloro-1h-indole or its enantiomers for the treatment of diseases and disorders responsive to 5-ht (serotonin) re-uptake inhibition
WO2003102097A1 (en) * 2002-05-31 2003-12-11 H. Lundbeck A/S The hydrochloride of (s)-(+)-3-[1-[2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-6-chloro-1h-indole
AU2003243930A1 (en) * 2002-07-05 2004-01-23 H. Lundbeck A/S Pharmaceutical composition comprising (s)-(+)-3-(1-(2-(1-acetyl-2,3-dihydro-1h-indol-3-yl)ethyl)-1,2,3,6-tetrahydropyridin-4-yl)-6-chloro-1h-indole
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
WO2004080407A2 (en) * 2003-03-07 2004-09-23 Predix Pharmaceuticals Holdings, Inc. New serotonin modulating compounds and uses therefor
KR20070011552A (ko) * 2004-05-11 2007-01-24 에지스 지오기스제르기아르 엔와이알티. ５-ｈｔ７ 수용체 활성제로서 알킬 옥스인돌의 피리딘유도체
CA2580020A1 (en) * 2004-09-09 2006-03-23 Ian M. Bell Aryl spirolactam cgrp receptor antagonists
DE602005016836D1 (de) * 2004-11-26 2009-11-05 Janssen Pharmaceutica Nv Chotischer und anxiolytischer aktivität
US7544685B2 (en) 2005-08-17 2009-06-09 H. Lundbeck A/S 2,3-dihydroindole compounds
AR057748A1 (es) * 2005-08-17 2007-12-12 Lundbeck & Co As H Derivados de 2,3 dihidroindol. composiciones farmaceuticas
JP2009515833A (ja) * 2005-10-24 2009-04-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−ピペリジン−４−イル−インドールｏｒｌ−１受容体モジュレーター
WO2008015516A1 (en) * 2006-07-28 2008-02-07 Pfizer Products Inc. Fused tricyclic heterocycles for the treatment of schizophrenia
KR20090083479A (ko) * 2006-11-28 2009-08-03 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체
PL395469A1 (pl) 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
EP3866927A4 (de) * 2018-10-17 2022-07-27 Nikang Therapeutics, Inc. Indanderivate als hypoxieinduzierbare faktor-2(alpha)-inhibitoren
GB201919213D0 (en) * 2019-12-23 2020-02-05 Ucb Biopharma Sprl Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds

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FR2654104B1 (fr) 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
TW199152B (de) 1990-11-01 1993-02-01 Takeda Pharm Industry Co Ltd
FR2670491B1 (fr) 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
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AU694212B2 (en) 1994-04-28 1998-07-16 Merck Sharp & Dohme Limited Benzofuran derivatives as d4 receptor antagonists
ZA954689B (en) * 1994-06-08 1996-01-29 Lundbeck & Co As H 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
CA2335711A1 (en) * 1998-06-19 1999-12-29 Ivan Mikkelsen 4,5,6 and 7-indole and indoline derivatives, their preparation and use

Also Published As

Publication number Publication date
ES2185058T3 (es) 2003-04-16
CZ297416B6 (cs) 2006-12-13
WO1998028293A1 (en) 1998-07-02
CN1515551A (zh) 2004-07-28
KR20000069621A (ko) 2000-11-25
TR199901407T2 (xx) 1999-08-23
AR008545A1 (es) 2000-01-19
EA199900581A1 (ru) 2000-04-24
CN1246117A (zh) 2000-03-01
KR100432297B1 (ko) 2004-05-20
EP0946542A1 (de) 1999-10-06
US6552044B2 (en) 2003-04-22
JP2000513731A (ja) 2000-10-17
EA002158B1 (ru) 2001-12-24
DE69716296D1 (de) 2002-11-14
IS2018B (is) 2005-06-15
AU731243B2 (en) 2001-03-29
BG103561A (en) 2000-06-30
AU5310998A (en) 1998-07-17
NO992895L (no) 1999-08-13
CN1244558C (zh) 2006-03-08
BR9714039A (pt) 2000-05-09
PL188418B1 (pl) 2005-01-31
IL130133A (en) 2005-08-31
DE69716296T2 (de) 2003-09-11
NZ335973A (en) 2000-11-24
EP0946542B1 (de) 2002-10-09
CN1495165A (zh) 2004-05-12
PL334011A1 (en) 2000-01-31
IS5061A (is) 1999-05-28
HK1025775A1 (en) 2000-11-24
US6262087B1 (en) 2001-07-17
UA66778C2 (uk) 2004-06-15
NO992895D0 (no) 1999-06-14
JP3251300B2 (ja) 2002-01-28
BG63968B1 (bg) 2003-08-29
ZA9711376B (en) 1998-07-21
PT946542E (pt) 2003-02-28
HUP0000079A3 (en) 2002-11-28
NO20044514L (no) 1999-08-13
CN1282644C (zh) 2006-11-01
DK0946542T3 (da) 2003-02-10
CZ222799A3 (cs) 1999-12-15
CN1146556C (zh) 2004-04-21
HUP0000079A2 (hu) 2001-10-28
NO318978B1 (no) 2005-05-30
US6352988B2 (en) 2002-03-05
US20010021777A1 (en) 2001-09-13
IL130133A0 (en) 2000-06-01
SK283678B6 (sk) 2003-11-04
US20010020095A1 (en) 2001-09-06
SK81399A3 (en) 1999-12-10

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