EA200601088A1 - НОВЫЙ СПОСОБ СИНТЕЗА (2S,3aS,7aS)-[(S)-АЛАНИЛ]ОКТАГИДРО-1Н-ИНДОЛ-2-КАРБОНОВЫХ КИСЛОТ И ИХ ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА - Google Patents

НОВЫЙ СПОСОБ СИНТЕЗА (2S,3aS,7aS)-[(S)-АЛАНИЛ]ОКТАГИДРО-1Н-ИНДОЛ-2-КАРБОНОВЫХ КИСЛОТ И ИХ ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА

Info

Publication number
EA200601088A1
EA200601088A1 EA200601088A EA200601088A EA200601088A1 EA 200601088 A1 EA200601088 A1 EA 200601088A1 EA 200601088 A EA200601088 A EA 200601088A EA 200601088 A EA200601088 A EA 200601088A EA 200601088 A1 EA200601088 A1 EA 200601088A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
perindopril
octagidro
alanyl
indol
Prior art date
Application number
EA200601088A
Other languages
English (en)
Other versions
EA010318B1 (ru
Inventor
Тьерри Дюбюффе
Жан-Пьер Лекув
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200601088A1 publication Critical patent/EA200601088A1/ru
Publication of EA010318B1 publication Critical patent/EA010318B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Способ синтеза соединений формулы (I)в которой R представляет собой атом водорода или защитную группу для аминогруппы.Заявляется синтез периндоприла и его фармацевтически приемлемых солей.
EA200601088A 2003-12-10 2004-12-09 НОВЫЙ СПОСОБ СИНТЕЗА (2S,3aS,7aS)-1-[(S)-АЛАНИЛ]ОКТАГИДРО-1H-ИНДОЛ-2-КАРБОНОВЫХ КИСЛОТ И ИХ ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА EA010318B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03293085A EP1420030A3 (fr) 2003-12-10 2003-12-10 Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
PCT/FR2004/003167 WO2005066199A1 (fr) 2003-12-10 2004-12-09 Procede de synthese de derives de l’acide (2s,3as,7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylique et application a la synthese du perindopril

Publications (2)

Publication Number Publication Date
EA200601088A1 true EA200601088A1 (ru) 2006-12-29
EA010318B1 EA010318B1 (ru) 2008-08-29

Family

ID=32116382

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601088A EA010318B1 (ru) 2003-12-10 2004-12-09 НОВЫЙ СПОСОБ СИНТЕЗА (2S,3aS,7aS)-1-[(S)-АЛАНИЛ]ОКТАГИДРО-1H-ИНДОЛ-2-КАРБОНОВЫХ КИСЛОТ И ИХ ПРИМЕНЕНИЕ В СИНТЕЗЕ ПЕРИНДОПРИЛА

Country Status (20)

Country Link
US (1) US7288661B2 (ru)
EP (1) EP1420030A3 (ru)
JP (1) JP2007537996A (ru)
KR (1) KR20060096521A (ru)
CN (1) CN100469787C (ru)
AR (1) AR047328A1 (ru)
AU (1) AU2004312186A1 (ru)
BR (1) BRPI0417540A (ru)
CA (1) CA2548406A1 (ru)
EA (1) EA010318B1 (ru)
GE (1) GEP20084408B (ru)
HK (1) HK1095840A1 (ru)
MA (1) MA28223A1 (ru)
MY (1) MY136937A (ru)
NO (1) NO20063027L (ru)
NZ (1) NZ547555A (ru)
PL (1) PL380411A1 (ru)
UA (1) UA84897C2 (ru)
WO (1) WO2005066199A1 (ru)
ZA (1) ZA200604368B (ru)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
US20070123581A1 (en) 2007-05-31
GEP20084408B (en) 2008-06-25
BRPI0417540A (pt) 2007-03-27
CA2548406A1 (fr) 2005-07-21
AR047328A1 (es) 2006-01-18
CN1890259A (zh) 2007-01-03
AU2004312186A1 (en) 2005-07-21
EP1420030A3 (fr) 2004-05-26
NZ547555A (en) 2009-11-27
JP2007537996A (ja) 2007-12-27
EP1420030A2 (fr) 2004-05-19
US7288661B2 (en) 2007-10-30
WO2005066199A1 (fr) 2005-07-21
HK1095840A1 (en) 2007-05-18
UA84897C2 (en) 2008-12-10
MA28223A1 (fr) 2006-10-02
PL380411A1 (pl) 2007-01-22
ZA200604368B (en) 2007-10-31
EA010318B1 (ru) 2008-08-29
MY136937A (en) 2008-11-28
NO20063027L (no) 2006-06-28
CN100469787C (zh) 2009-03-18
KR20060096521A (ko) 2006-09-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU