BR0211334A - Processo de sìntese de derivados do ácido (2s, 3as, 7as)-1-[(s)alanil]-octahidro-lh-indol-2-carboxìlico e aplicação a sìntese do perindopril - Google Patents

Processo de sìntese de derivados do ácido (2s, 3as, 7as)-1-[(s)alanil]-octahidro-lh-indol-2-carboxìlico e aplicação a sìntese do perindopril

Info

Publication number
BR0211334A
BR0211334A BR0211334-1A BR0211334A BR0211334A BR 0211334 A BR0211334 A BR 0211334A BR 0211334 A BR0211334 A BR 0211334A BR 0211334 A BR0211334 A BR 0211334A
Authority
BR
Brazil
Prior art keywords
synthesis
perindopril
application
alanyl
carboxylic acid
Prior art date
Application number
BR0211334-1A
Other languages
English (en)
Inventor
Tibor Mezei
Marta Porcs-Makkay
Gyula Simig
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0211334(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0211334A publication Critical patent/BR0211334A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

"PROCESSO DE SìNTESE DE DERIVADOS DO áCIDO (2S, 3aS, 7aS)-1-[(S)-ALANIL]-OCTAHIDRO-1H-INDOL-2-CARBOXìLICO E APLICAçãO à SìNTESE DO PERINDOPRIL". A presente invenção refere-se a um processo de síntese industrial dos compostos de fórmula (I), na qual R~ 1~ representa um átomo de hidrogênio ou um grupamento alquila ou benzila e R~ 2~ representa um grupamento protetor da função amino. Aplicação à síntese do perindopril e de seus sais farmaceuticamente aceitáveis.
BR0211334-1A 2001-07-24 2002-07-23 Processo de sìntese de derivados do ácido (2s, 3as, 7as)-1-[(s)alanil]-octahidro-lh-indol-2-carboxìlico e aplicação a sìntese do perindopril BR0211334A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0109839A FR2827860B1 (fr) 2001-07-24 2001-07-24 Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
PCT/FR2002/002627 WO2003016336A1 (fr) 2001-07-24 2002-07-23 NOUVEAU PROCEDE DE SYNTHESE DE DERIVES DE L'ACIDE (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIQUE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL

Publications (1)

Publication Number Publication Date
BR0211334A true BR0211334A (pt) 2004-09-28

Family

ID=8865826

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211334-1A BR0211334A (pt) 2001-07-24 2002-07-23 Processo de sìntese de derivados do ácido (2s, 3as, 7as)-1-[(s)alanil]-octahidro-lh-indol-2-carboxìlico e aplicação a sìntese do perindopril

Country Status (25)

Country Link
US (1) US7060842B2 (pt)
EP (1) EP1256590B1 (pt)
JP (1) JP3868957B2 (pt)
KR (1) KR100607556B1 (pt)
CN (1) CN1533398A (pt)
AR (1) AR035081A1 (pt)
AT (1) ATE318838T1 (pt)
AU (1) AU2002334027B8 (pt)
BR (1) BR0211334A (pt)
CA (1) CA2455706C (pt)
DE (1) DE60209458T2 (pt)
DK (1) DK1256590T3 (pt)
EA (1) EA005490B1 (pt)
ES (1) ES2259071T3 (pt)
FR (1) FR2827860B1 (pt)
HU (1) HU229396B1 (pt)
MA (1) MA27130A1 (pt)
MX (1) MXPA04000443A (pt)
NO (1) NO328234B1 (pt)
NZ (1) NZ530427A (pt)
PL (1) PL212408B1 (pt)
PT (1) PT1256590E (pt)
SI (1) SI1256590T1 (pt)
WO (1) WO2003016336A1 (pt)
ZA (1) ZA200400246B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1333026T1 (sl) 2002-01-30 2007-10-31 Servier Lab Postopek priprave perindoprila visoke äśistoäśe in intermediatov uporabnih v sintezi
ES2250846T3 (es) * 2003-02-28 2006-04-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1603558T3 (da) 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf
ATE307801T1 (de) * 2003-02-28 2005-11-15 Servier Lab Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
ATE305939T1 (de) * 2003-02-28 2005-10-15 Servier Lab Verfahren zur synthese von (2s,3as,7as)-1-((s)-
EP1321471B1 (fr) * 2003-03-12 2005-05-04 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
ATE280775T1 (de) * 2003-03-12 2004-11-15 Servier Lab Verfahren zur synthese von (2s,3as,7as)-1-((s)-
DK1323729T3 (da) * 2003-03-12 2005-02-14 Servier Lab Fremgangsmåde til syntese af (2S, 3aS, 7aS)-perhydroindol-2-carboxylsyre og estere heraf, samt anvendelse heraf ved syntese af perindopril
ATE540924T1 (de) 2003-06-24 2012-01-15 Servier Lab Neue kristalline formen von perindopril erbumine
DE60307721T2 (de) * 2003-07-31 2007-10-18 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
JP4720132B2 (ja) * 2003-10-30 2011-07-13 住友化学株式会社 光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko) 2006-12-19 2013-11-15 에스케이바이오팜 주식회사 옥타하이드로인돌-2-카르복시산의 제조방법
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
JP3868957B2 (ja) 2007-01-17
US7060842B2 (en) 2006-06-13
JP2005500386A (ja) 2005-01-06
MXPA04000443A (es) 2004-03-18
CA2455706C (fr) 2012-01-24
DE60209458T2 (de) 2006-10-12
HU0202437D0 (pt) 2002-10-28
PT1256590E (pt) 2006-06-30
CN1533398A (zh) 2004-09-29
EA005490B1 (ru) 2005-02-24
HUP0202437A2 (hu) 2003-02-28
HU229396B1 (hu) 2013-11-28
NO20040151L (no) 2004-01-13
MA27130A1 (fr) 2005-01-03
AU2002334027A1 (en) 2003-03-03
ZA200400246B (en) 2006-07-26
PL355159A1 (en) 2003-01-13
NZ530427A (en) 2005-08-26
ATE318838T1 (de) 2006-03-15
AR035081A1 (es) 2004-04-14
CA2455706A1 (fr) 2003-02-27
FR2827860A1 (fr) 2003-01-31
AU2002334027B2 (en) 2006-12-14
KR100607556B1 (ko) 2006-08-02
EA200400110A1 (ru) 2004-06-24
EP1256590A1 (fr) 2002-11-13
PL212408B1 (pl) 2012-09-28
KR20040023673A (ko) 2004-03-18
DK1256590T3 (da) 2006-06-06
ES2259071T3 (es) 2006-09-16
HUP0202437A3 (en) 2003-05-28
NO328234B1 (no) 2010-01-11
DE60209458D1 (de) 2006-04-27
WO2003016336A1 (fr) 2003-02-27
FR2827860B1 (fr) 2004-12-10
AU2002334027B8 (en) 2007-01-25
US20040198988A1 (en) 2004-10-07
EP1256590B1 (fr) 2006-03-01
SI1256590T1 (sl) 2006-06-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2524 DE 21-05-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.